Prostaglandin-endoperoxide synthase 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• enzyme binding Source: Ensembl
• heme binding Source: Ensembl
• peroxidase activity Source: InterPro
• prostaglandin-endoperoxide synthase activity Source: Ensembl
• protein homodimerization activity Source: Ensembl

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• brown fat cell differentiation Source: Ensembl
• cellular response to fluid shear stress Source: Ensembl
• cellular response to hypoxia Source: Ensembl
• cellular response to non-ionic osmotic stress Source: Ensembl
• cyclooxygenase pathway Source: Ensembl
• decidualization Source: Ensembl
• embryo implantation Source: Ensembl
• inflammatory response Source: InterPro
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
• negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: Ensembl
• positive regulation of brown fat cell differentiation Source: Ensembl
• positive regulation of fever generation Source: Ensembl
• positive regulation of peptidyl-serine phosphorylation Source: Ensembl
• positive regulation of prostaglandin biosynthetic process Source: Ensembl
• regulation of blood pressure Source: Ensembl
• regulation of cell proliferation Source: Ensembl
• response to oxidative stress Source: InterPro

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• enzyme binding Source: Ensembl
• protein homodimerization activity Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSVGFDQYKC DCTRTGFYGE NCSTPEFLTR IKLLLKPTPN TVHYILTHFK 
        60         70         80         90        100
GFWNVVNNIP FLRNAIMSYV LTSRSHLIDS PPTYNADYGY KSWEAFSNLS 
       110        120        130        140        150
YYTRALPPVP DDCPTPLGVK GKKQLPDSNE IVEKFLLRRK FIPDPQGTNM 
       160        170        180        190        200
MFAFFAQHFT HQFFKTDHKR GPAFTKGLGH GVDLNHIYGE TLDRQHKLRL 
       210        220        230        240        250
FKDGKMKYQI IDGEMYPPTV KDTQAEMIYP PQVPEHLRFA VGQEVFGLVP 
       260        270        280        290        300
GLMMYATIWL REHNRVCDVL KQEHPEWGDE QLFQTSRLIL IGETIKIVIE 
       310        320        330        340        350
DYVQHLSGYH FKLKFDPELL FNKQFQYQNR IAAEFNTLYH WHPLLPDNFQ 
       360        370        380        390        400
IHDQKYNYQQ FIYNNSILLE HGITQFVESF TRQIAGRVAG GRNVPPAVQK 
       410        420        430        440        450
VSQASIDQSR QMKYQSFNEY RKRFMLKPYE SFEELTGEKE MSAELEALYG 
       460        470        480        490        500
DIDAVELYPA LLVEKPRPDA IFGETMVEVG APFSLKGLMG NVICSPAYWK 
       510        520        530        540        550
PSTFGGEVGF QIINTASIQS LICNNVKGCP FTSFSVPDPE LIKTVTINAS 
       560        570 
SSRSRLDDIN PTVLLKERST EL                               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Caution

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ