PTGS2

Functionⁱ

GO - Molecular functionⁱ

enzyme binding Source: Ensembl
heme binding Source: Ensembl
peroxidase activity Source: InterPro
prostaglandin-endoperoxide synthase activity Source: Ensembl
protein homodimerization activity Source: Ensembl

GO - Biological processⁱ

brown fat cell differentiation Source: Ensembl
cellular response to fluid shear stress Source: Ensembl
cellular response to hypoxia Source: Ensembl
cellular response to non-ionic osmotic stress Source: Ensembl
cyclooxygenase pathway Source: Ensembl
decidualization Source: Ensembl
embryo implantation Source: Ensembl
inflammatory response Source: InterPro
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: Ensembl
positive regulation of brown fat cell differentiation Source: Ensembl
positive regulation of fever generation Source: Ensembl
positive regulation of peptidyl-serine phosphorylation Source: Ensembl
positive regulation of prostaglandin biosynthetic process Source: Ensembl
regulation of blood pressure Source: Ensembl
regulation of cell proliferation Source: Ensembl
response to oxidative stress Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Prostaglandin-endoperoxide synthase 2Imported
Gene namesⁱ	Name:PTGS2Imported
Organismⁱ	Macaca mulatta (Rhesus macaque)Imported
Taxonomic identifierⁱ	9544 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Macaca
Proteomesⁱ	UP000006718 Componentⁱ: Chromosome 1

Subcellular locationⁱ

GO (Gene Ontology) annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMMUG00000016857.

Bgeeⁱ

ENSMMUG00000016857.

Interactionⁱ

GO - Molecular functionⁱ

enzyme binding Source: Ensembl
protein homodimerization activity Source: Ensembl

Complete GO annotation...

Protein-protein interaction databases

STRINGⁱ	9544.ENSMMUP00000022160.

STRINGⁱ

9544.ENSMMUP00000022160.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 23	EGF-likeInterPro annotationAdd BLAST		23

Keywords - Domainⁱ

EGF-like domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG2408. Eukaryota. ENOG410XPZ3. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010743.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03CD.
TreeFamⁱ	TF329675.

Family and domain databases

Gene3Dⁱ	1.10.640.10. 1 hit.
InterProⁱ	View protein in InterPro IPR029576. COX-2. IPR000742. EGF-like_dom. IPR010255. Haem_peroxidase. IPR019791. Haem_peroxidase_animal.
PANTHERⁱ	PTHR11903:SF18. PTHR11903:SF18. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03098. An_peroxidase. 1 hit.
PRINTSⁱ	PR00457. ANPEROXIDASE.
SUPFAMⁱ	SSF48113. SSF48113. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50026. EGF_3. 1 hit. PS50292. PEROXIDASE_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

F7BWZ9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSVGFDQYKC DCTRTGFYGE NCSTPEFLTR IKLLLKPTPN TVHYILTHFK 
        60         70         80         90        100
GFWNVVNNIP FLRNAIMSYV LTSRSHLIDS PPTYNADYGY KSWEAFSNLS 
       110        120        130        140        150
YYTRALPPVP DDCPTPLGVK GKKQLPDSNE IVEKFLLRRK FIPDPQGTNM 
       160        170        180        190        200
MFAFFAQHFT HQFFKTDHKR GPAFTKGLGH GVDLNHIYGE TLDRQHKLRL 
       210        220        230        240        250
FKDGKMKYQI IDGEMYPPTV KDTQAEMIYP PQVPEHLRFA VGQEVFGLVP 
       260        270        280        290        300
GLMMYATIWL REHNRVCDVL KQEHPEWGDE QLFQTSRLIL IGETIKIVIE 
       310        320        330        340        350
DYVQHLSGYH FKLKFDPELL FNKQFQYQNR IAAEFNTLYH WHPLLPDNFQ 
       360        370        380        390        400
IHDQKYNYQQ FIYNNSILLE HGITQFVESF TRQIAGRVAG GRNVPPAVQK 
       410        420        430        440        450
VSQASIDQSR QMKYQSFNEY RKRFMLKPYE SFEELTGEKE MSAELEALYG 
       460        470        480        490        500
DIDAVELYPA LLVEKPRPDA IFGETMVEVG APFSLKGLMG NVICSPAYWK 
       510        520        530        540        550
PSTFGGEVGF QIINTASIQS LICNNVKGCP FTSFSVPDPE LIKTVTINAS 
       560        570 
SSRSRLDDIN PTVLLKERST EL

Length:572

Mass (Da):65,812

Last modified:November 30, 2016 - v2

Checksum:ⁱ81FC232A6BC537B4

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	JSUE03003228 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

JSUE03003228 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENSMMUT00000023682; ENSMMUP00000022160; ENSMMUG00000016857.

Ensemblⁱ

ENSMMUT00000023682; ENSMMUP00000022160; ENSMMUG00000016857.

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F7BWZ9	G7MF20 G7NXE8 Q56NJ0	Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	604	UniRef100_G7MF20	Cluster: Uncharacterized protein	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F7BWZ9	P35354 UPI0007D70FB9 H9FLI1 D9MWI3 F7HZJ7 U3DE75 H2Q0S9 G7MF20 G7NXE8 Q56NJ0 +17	Homo sapiens (Human) Macaca mulatta (Rhesus macaque) Callithrix jacchus (White-tufted-ear marmoset) Pan troglodytes (Chimpanzee) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Gorilla gorilla gorilla (Western lowland gorilla) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Papio anubis (Olive baboon) Tarsius syrichta (Philippine tarsier) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) And more	604	UniRef90_P35354	Cluster: Prostaglandin G/H synthase 2	28

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F7BWZ9	P05979 UPI00083F46D0 M3WEM6 UPI00083F31F9 UPI0000D9DD9A UPI0005F4C6DF UPI0005F5598D UPI0005F4A51C UPI0005F360F7 UPI0005F55236 +509	Ovis aries (Sheep) Papio anubis (Olive baboon) Felis catus (Cat) (Felis silvestris catus) Macaca mulatta (Rhesus macaque) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Macaca nemestrina (Pig-tailed macaque) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Callithrix jacchus (White-tufted-ear marmoset) Aotus nancymaae (Ma's night monkey) And more	600	UniRef50_P05979	Cluster: Prostaglandin G/H synthase 1	520

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	JSUE03003228 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

JSUE03003228 Genomic DNA. No translation available.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9544.ENSMMUP00000022160.

STRINGⁱ

9544.ENSMMUP00000022160.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMMUT00000023682; ENSMMUP00000022160; ENSMMUG00000016857.

Ensemblⁱ

ENSMMUT00000023682; ENSMMUP00000022160; ENSMMUG00000016857.

Phylogenomic databases

eggNOGⁱ	KOG2408. Eukaryota. ENOG410XPZ3. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010743.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03CD.
TreeFamⁱ	TF329675.

Gene expression databases

Bgeeⁱ	ENSMMUG00000016857.

Bgeeⁱ

ENSMMUG00000016857.

Family and domain databases

Gene3Dⁱ	1.10.640.10. 1 hit.
InterProⁱ	View protein in InterPro IPR029576. COX-2. IPR000742. EGF-like_dom. IPR010255. Haem_peroxidase. IPR019791. Haem_peroxidase_animal.
PANTHERⁱ	PTHR11903:SF18. PTHR11903:SF18. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03098. An_peroxidase. 1 hit.
PRINTSⁱ	PR00457. ANPEROXIDASE.
SUPFAMⁱ	SSF48113. SSF48113. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50026. EGF_3. 1 hit. PS50292. PEROXIDASE_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F7BWZ9_MACMU
Accessionⁱ	F7BWZ9Primary (citable) accession number: F7BWZ9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 27, 2011
	Last sequence update:	November 30, 2016
	Last modified:	August 30, 2017
	This is version 50 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - F7BWZ9 (F7BWZ9_MACMU)

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Prostaglandin-endoperoxide synthase 2

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Endoplasmic reticulum

Other locations

Expressionⁱ

Gene expression databases

Interactionⁱ

GO - Molecular functionⁱ

Protein-protein interaction databases

Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Caution

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F7BWZ9 (F7BWZ9_MACMU)

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Prostaglandin-endoperoxide synthase 2

PTGS2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Other locations

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ