UniProtKB - F7BWZ9 (F7BWZ9_MACMU)
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Protein
Submitted name:
Prostaglandin-endoperoxide synthase 2
Gene
PTGS2
Organism
Macaca mulatta (Rhesus macaque)
Status
Functioni
GO - Molecular functioni
- enzyme binding Source: Ensembl
- heme binding Source: Ensembl
- peroxidase activity Source: InterPro
- prostaglandin-endoperoxide synthase activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
GO - Biological processi
- brown fat cell differentiation Source: Ensembl
- cellular response to fluid shear stress Source: Ensembl
- cellular response to hypoxia Source: Ensembl
- cellular response to non-ionic osmotic stress Source: Ensembl
- cyclooxygenase pathway Source: Ensembl
- decidualization Source: Ensembl
- embryo implantation Source: Ensembl
- inflammatory response Source: InterPro
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: Ensembl
- positive regulation of brown fat cell differentiation Source: Ensembl
- positive regulation of fever generation Source: Ensembl
- positive regulation of peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of prostaglandin biosynthetic process Source: Ensembl
- regulation of blood pressure Source: Ensembl
- regulation of cell proliferation Source: Ensembl
- response to oxidative stress Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Prostaglandin-endoperoxide synthase 2Imported |
Gene namesi | Name:PTGS2Imported |
Organismi | Macaca mulatta (Rhesus macaque)Imported |
Taxonomic identifieri | 9544 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Subcellular locationi
Interactioni
GO - Molecular functioni
- enzyme binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
Protein-protein interaction databases
STRINGi | 9544.ENSMMUP00000022160. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 23 | EGF-likeInterPro annotationAdd BLAST | 23 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG2408. Eukaryota. ENOG410XPZ3. LUCA. |
GeneTreei | ENSGT00390000010743. |
OrthoDBi | EOG091G03CD. |
TreeFami | TF329675. |
Family and domain databases
Gene3Di | 1.10.640.10. 1 hit. |
InterProi | View protein in InterPro IPR029576. COX-2. IPR000742. EGF-like_dom. IPR010255. Haem_peroxidase. IPR019791. Haem_peroxidase_animal. IPR037120. Haem_peroxidase_sf. |
PANTHERi | PTHR11903:SF8. PTHR11903:SF8. 1 hit. |
Pfami | View protein in Pfam PF03098. An_peroxidase. 1 hit. |
PRINTSi | PR00457. ANPEROXIDASE. |
SUPFAMi | SSF48113. SSF48113. 1 hit. |
PROSITEi | View protein in PROSITE PS50026. EGF_3. 1 hit. PS50292. PEROXIDASE_3. 1 hit. |
i Sequence
Sequence statusi: Complete.
F7BWZ9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVGFDQYKC DCTRTGFYGE NCSTPEFLTR IKLLLKPTPN TVHYILTHFK
60 70 80 90 100
GFWNVVNNIP FLRNAIMSYV LTSRSHLIDS PPTYNADYGY KSWEAFSNLS
110 120 130 140 150
YYTRALPPVP DDCPTPLGVK GKKQLPDSNE IVEKFLLRRK FIPDPQGTNM
160 170 180 190 200
MFAFFAQHFT HQFFKTDHKR GPAFTKGLGH GVDLNHIYGE TLDRQHKLRL
210 220 230 240 250
FKDGKMKYQI IDGEMYPPTV KDTQAEMIYP PQVPEHLRFA VGQEVFGLVP
260 270 280 290 300
GLMMYATIWL REHNRVCDVL KQEHPEWGDE QLFQTSRLIL IGETIKIVIE
310 320 330 340 350
DYVQHLSGYH FKLKFDPELL FNKQFQYQNR IAAEFNTLYH WHPLLPDNFQ
360 370 380 390 400
IHDQKYNYQQ FIYNNSILLE HGITQFVESF TRQIAGRVAG GRNVPPAVQK
410 420 430 440 450
VSQASIDQSR QMKYQSFNEY RKRFMLKPYE SFEELTGEKE MSAELEALYG
460 470 480 490 500
DIDAVELYPA LLVEKPRPDA IFGETMVEVG APFSLKGLMG NVICSPAYWK
510 520 530 540 550
PSTFGGEVGF QIINTASIQS LICNNVKGCP FTSFSVPDPE LIKTVTINAS
560 570
SSRSRLDDIN PTVLLKERST EL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JSUE03003228 Genomic DNA. No translation available. |
Genome annotation databases
Ensembli | ENSMMUT00000023682; ENSMMUP00000022160; ENSMMUG00000016857. |
Similar proteinsi
Entry informationi
Entry namei | F7BWZ9_MACMU | |
Accessioni | F7BWZ9Primary (citable) accession number: F7BWZ9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | November 30, 2016 | |
Last modified: | March 28, 2018 | |
This is version 53 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |
Miscellaneousi
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation