ID   F7B227_MOUSE            Unreviewed;       177 AA.
AC   F7B227;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=Enoyl coenzyme A hydratase 1, peroxisomal {ECO:0000313|Ensembl:ENSMUSP00000116992.2};
DE   Flags: Fragment;
GN   Name=Ech1 {ECO:0000313|Ensembl:ENSMUSP00000116992.2,
GN   ECO:0000313|MGI:MGI:1858208};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000116992.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000116992.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000116992.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0007829|PubMed:23806337}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA   Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA   Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT   "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT   pathways.";
RL   Mol. Cell 50:919-930(2013).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000116992.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000116992.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
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DR   AlphaFoldDB; F7B227; -.
DR   SMR; F7B227; -.
DR   IntAct; F7B227; 1.
DR   MINT; F7B227; -.
DR   SwissPalm; F7B227; -.
DR   jPOST; F7B227; -.
DR   MaxQB; F7B227; -.
DR   PeptideAtlas; F7B227; -.
DR   ProteomicsDB; 320289; -.
DR   Antibodypedia; 1042; 303 antibodies from 30 providers.
DR   Ensembl; ENSMUST00000132376.2; ENSMUSP00000116992.2; ENSMUSG00000053898.13.
DR   AGR; MGI:1858208; -.
DR   MGI; MGI:1858208; Ech1.
DR   VEuPathDB; HostDB:ENSMUSG00000053898; -.
DR   GeneTree; ENSGT00940000159610; -.
DR   HOGENOM; CLU_009834_7_0_1; -.
DR   UniPathway; UPA00659; -.
DR   ChiTaRS; Ech1; mouse.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000053898; Expressed in heart right ventricle and 261 other cell types or tissues.
DR   ExpressionAtlas; F7B227; baseline and differential.
DR   GO; GO:0016853; F:isomerase activity; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.12.10; Lyase 2-enoyl-coa Hydratase, Chain A, domain 2; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045002; Ech1-like.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR   PANTHER; PTHR43149:SF1; DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43149; ENOYL-COA HYDRATASE; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
PE   1: Evidence at protein level;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Proteomics identification {ECO:0007829|EPD:F7B227,
KW   ECO:0007829|MaxQB:F7B227};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000116992.2"
SQ   SEQUENCE   177 AA;  19319 MW;  B66DC8F6F189722D CRC64;
     QKISKDSDCR AVVVSGAGKM FTSGVDLVSA CDIRYCTQDA FFQIKEVDMG LAADVGTLQR
     LPKVIGNQSL VNELTFSARK MMADEALDSG LVSRVFQDKD AMLNAAFALA ADISSKSPVA
     VQGSKINLIY SRDHSVDESL DYMATWNMSM LQTQDIIKSV QAAMEKRDTK SITFSKL
//