CASP3

Functionⁱ

GO - Molecular functionⁱ

aspartic-type endopeptidase activity Source: Ensembl
cyclin-dependent protein serine/threonine kinase inhibitor activity Source: Ensembl
cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

B cell homeostasis Source: Ensembl
cell fate commitment Source: Ensembl
cellular response to DNA damage stimulus Source: Ensembl
cellular response to staurosporine Source: Ensembl
erythrocyte differentiation Source: GO_Central
execution phase of apoptosis Source: GO_Central
glial cell apoptotic process Source: Ensembl
heart development Source: Ensembl
intrinsic apoptotic signaling pathway in response to osmotic stress Source: Ensembl
keratinocyte differentiation Source: GO_Central
negative regulation of activated T cell proliferation Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
negative regulation of B cell proliferation Source: Ensembl
negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
neuron apoptotic process Source: Ensembl
neuron differentiation Source: GO_Central
neurotrophin TRK receptor signaling pathway Source: Ensembl
positive regulation of apoptotic process Source: Ensembl
protein processing Source: Ensembl
response to UV Source: Ensembl
response to wounding Source: Ensembl
sensory perception of sound Source: Ensembl
T cell homeostasis Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol proteaseSAAS annotation

Molecular function

Hydrolase, Protease, Thiol proteaseSAAS annotation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C14.003.

MEROPSⁱ

C14.003.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Caspase-3-like proteinImported
Gene namesⁱ	Name:CASP3Imported
Organismⁱ	Equus caballus (Horse)Imported
Taxonomic identifierⁱ	9796 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › Equus
Proteomesⁱ	UP000002281 Componentⁱ: Chromosome 27

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm Source: GO_Central
cytosol Source: Ensembl
nucleus Source: Ensembl

Complete GO annotation...

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9796.ENSECAP00000019797.

STRINGⁱ

9796.ENSECAP00000019797.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	43 – 167	CASPASE_P20InterPro annotationAdd BLAST		125
Domainⁱ	183 – 277	CASPASE_P10InterPro annotationAdd BLAST		95

Sequence similaritiesⁱ

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3573. Eukaryota. ENOG410ZQIE. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118912.
KEGG Orthology (KO) More...KOⁱ	K02187.
OMAⁱ	NHEFFTI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05YD.
TreeFamⁱ	TF102023.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00032. CASc. 1 hit.
InterProⁱ	View protein in InterPro IPR029030. Caspase-like_dom. IPR015470. Caspase_3. IPR033139. Caspase_cys_AS. IPR016129. Caspase_his_AS. IPR002138. Pept_C14_p10. IPR001309. Pept_C14_p20. IPR015917. Pept_C14A.
PANTHERⁱ	PTHR10454:SF178. PTHR10454:SF178. 1 hit.
PRINTSⁱ	PR00376. IL1BCENZYME.
SMARTⁱ	View protein in SMART SM00115. CASc. 1 hit.
SUPFAMⁱ	SSF52129. SSF52129. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

F7A730-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MENSKISVDS KSIKNSETKI LHGSKSMDSG ISLDSSYKMD YPEMGLCIII 
        60         70         80         90        100
NNKNFHKSTG MASRSGTDVD AANLRETFTN LKYEVRNKND LTGEEIVALM 
       110        120        130        140        150
RSVSKEDHSK RSSFICVLLS HGEEGIIFGT NGPIDLKKLT CFFKGDCCRS 
       160        170        180        190        200
LAGKPKLFII QACRGTELDS GIETDSGIED DMACQKIPVE ADFLYAYSTA 
       210        220        230        240        250
PGYYSWRNSK DGSWFIQSLC AMLKLYAHKL ELMHILTRVN RKVAMEFESY 
       260        270 
CLDPTFHGKK QIPCIVSMLT KELYFYH

Length:277

Mass (Da):31,194

Last modified:July 27, 2011 - v1

Checksum:ⁱFCD2B0229F9FF8B9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	JL627400 mRNA. Translation: AEQ00049.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001157433.1. NM_001163961.1.
UniGeneⁱ	Eca.2296.

Genome annotation databases

Ensemblⁱ	ENSECAT00000023864; ENSECAP00000019797; ENSECAG00000022197.
GeneIDⁱ	100034083.
KEGGⁱ	ecb:100034083.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	JL627400 mRNA. Translation: AEQ00049.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001157433.1. NM_001163961.1.
UniGeneⁱ	Eca.2296.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9796.ENSECAP00000019797.

STRINGⁱ

9796.ENSECAP00000019797.

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C14.003.

MEROPSⁱ

C14.003.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSECAT00000023864; ENSECAP00000019797; ENSECAG00000022197.
GeneIDⁱ	100034083.
KEGGⁱ	ecb:100034083.

Organism-specific databases

CTDⁱ	836.

CTDⁱ

836.

Phylogenomic databases

eggNOGⁱ	KOG3573. Eukaryota. ENOG410ZQIE. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118912.
KEGG Orthology (KO) More...KOⁱ	K02187.
OMAⁱ	NHEFFTI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05YD.
TreeFamⁱ	TF102023.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00032. CASc. 1 hit.
InterProⁱ	View protein in InterPro IPR029030. Caspase-like_dom. IPR015470. Caspase_3. IPR033139. Caspase_cys_AS. IPR016129. Caspase_his_AS. IPR002138. Pept_C14_p10. IPR001309. Pept_C14_p20. IPR015917. Pept_C14A.
PANTHERⁱ	PTHR10454:SF178. PTHR10454:SF178. 1 hit.
PRINTSⁱ	PR00376. IL1BCENZYME.
SMARTⁱ	View protein in SMART SM00115. CASc. 1 hit.
SUPFAMⁱ	SSF52129. SSF52129. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F7A730_HORSE
Accessionⁱ	F7A730Primary (citable) accession number: F7A730
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 27, 2011
	Last sequence update:	July 27, 2011
	Last modified:	June 7, 2017
	This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - F7A730 (F7A730_HORSE)

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Caspase-3-like protein

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Protein family/group databases

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Protein-protein interaction databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F7A730 (F7A730_HORSE)

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Caspase-3-like protein

CASP3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ