F6ZV96 (F6ZV96_MACMU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Apoptosis regulator BAX isoform alpha EMBL AFE64837.1

Submitted name:
Uncharacterized protein Ensembl ENSMMUP00000005209

Gene names

Name:

BAX Ensembl ENSMMUP00000005209 EMBL AFE64837.1

Organism

Macaca mulatta (Rhesus macaque) [Reference proteome] Ensembl ENSMMUP00000005209

Taxonomic identifier

9544 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB B cell homeostasis Inferred from electronic annotation. Source: Compara B cell homeostatic proliferation Inferred from electronic annotation. Source: Compara B cell negative selection Inferred from electronic annotation. Source: Compara Sertoli cell proliferation Inferred from electronic annotation. Source: Compara T cell homeostatic proliferation Inferred from electronic annotation. Source: Compara activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Inferred from sequence or structural similarity. Source: UniProtKB apoptotic DNA fragmentation Inferred from sequence or structural similarity. Source: UniProtKB blood vessel remodeling Inferred from electronic annotation. Source: Compara cellular response to UV Inferred from electronic annotation. Source: Compara cellular response to organic substance Inferred from electronic annotation. Source: Compara cerebral cortex development Inferred from electronic annotation. Source: Compara cleavage of lamin involved in execution phase of apoptosis Inferred from sequence or structural similarity. Source: UniProtKB development of secondary sexual characteristics Inferred from electronic annotation. Source: Compara establishment or maintenance of transmembrane electrochemical gradient Inferred from sequence or structural similarity. Source: UniProtKB fertilization Inferred from electronic annotation. Source: Compara germ cell development Inferred from electronic annotation. Source: Compara germ cell programmed cell death Inferred from electronic annotation. Source: Compara glycosphingolipid metabolic process Inferred from electronic annotation. Source: Compara homeostasis of number of cells within a tissue Inferred from electronic annotation. Source: Compara hypothalamus development Inferred from electronic annotation. Source: Compara induction of apoptosis Inferred from electronic annotation. Source: Compara intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Inferred from sequence or structural similarity. Source: UniProtKB kidney development Inferred from electronic annotation. Source: Compara limb morphogenesis Inferred from electronic annotation. Source: Compara mitochondrial fragmentation involved in apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB mitochondrial fusion Inferred from sequence or structural similarity. Source: UniProtKB myeloid cell homeostasis Inferred from electronic annotation. Source: Compara negative regulation of fibroblast proliferation Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara negative regulation of protein binding Inferred from sequence or structural similarity. Source: UniProtKB neuron apoptotic process Inferred from electronic annotation. Source: Compara neuron migration Inferred from electronic annotation. Source: Compara nuclear fragmentation involved in apoptotic nuclear change Inferred from sequence or structural similarity. Source: UniProtKB odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara ovarian follicle development Inferred from electronic annotation. Source: Compara positive regulation of B cell apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process involved in mammary gland involution Inferred from electronic annotation. Source: Compara positive regulation of developmental pigmentation Inferred from electronic annotation. Source: Compara positive regulation of endoplasmic reticulum unfolded protein response Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of intrinsic apoptotic signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of neuron apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of protein oligomerization Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of release of cytochrome c from mitochondria Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of release of sequestered calcium ion into cytosol Inferred from electronic annotation. Source: Compara post-embryonic camera-type eye morphogenesis Inferred from electronic annotation. Source: Compara protein homooligomerization Inferred from electronic annotation. Source: Compara protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Inferred from electronic annotation. Source: Compara reduction of endoplasmic reticulum calcium ion concentration Inferred from electronic annotation. Source: Compara regulation of cell cycle Inferred from electronic annotation. Source: Compara regulation of mammary gland epithelial cell proliferation Inferred from electronic annotation. Source: Compara regulation of mitochondrial membrane potential Inferred from sequence or structural similarity. Source: UniProtKB regulation of nitrogen utilization Inferred from electronic annotation. Source: Compara regulation of protein heterodimerization activity Inferred from electronic annotation. Source: Compara regulation of protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB release of cytochrome c from mitochondria Inferred from sequence or structural similarity. Source: UniProtKB release of matrix enzymes from mitochondria Inferred from sequence or structural similarity. Source: UniProtKB response to DNA damage stimulus Inferred from electronic annotation. Source: Compara response to acid Inferred from electronic annotation. Source: Compara response to axon injury Inferred from electronic annotation. Source: Compara response to gamma radiation Inferred from electronic annotation. Source: Compara response to salt stress Inferred from electronic annotation. Source: Compara response to toxin Inferred from sequence or structural similarity. Source: UniProtKB retina development in camera-type eye Inferred from electronic annotation. Source: Compara retinal cell apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB retinal cell programmed cell death Inferred from electronic annotation. Source: Compara spermatid differentiation Inferred from electronic annotation. Source: Compara transformed cell apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB vagina development Inferred from electronic annotation. Source: Compara
Cellular_component	BAX complex Inferred from sequence or structural similarity. Source: UniProtKB cytosol Inferred from sequence or structural similarity. Source: UniProtKB cytosolic part Inferred from electronic annotation. Source: Compara endoplasmic reticulum membrane Inferred from sequence or structural similarity. Source: UniProtKB mitochondrial outer membrane Inferred from electronic annotation. Source: Compara mitochondrial permeability transition pore complex Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	BH3 domain binding Inferred from sequence or structural similarity. Source: UniProtKB channel activity Inferred from sequence or structural similarity. Source: UniProtKB lipid binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F6ZV96 [UniParc]. Last modified July 27, 2011. Version 1. Checksum: F47DFE0A76820BC9	FASTA	192	21,208
	10 20 30 40 50 60 MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG ETPELALDPV PQDASTKRLS 70 80 90 100 110 120 ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL 130 140 150 160 170 180 VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTILVAGV 190 LTASLTIWKK MG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary and biomedical insights from the rhesus macaque genome." Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C., Makova K.D., Miller W., Milosavljevic A. , Palermo R.E., Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., Zwieg A.S. Science 316:222-234(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 17573 Ensembl ENSMMUP00000005209.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: 17573 Ensembl ENSMMUP00000005209.
[3]	"De novo assembly of the rhesus macaque transcriptome from NextGen mRNA sequences." Pandey S., Maudhoo M.D., Guda C., Ferguson B., Fox H., Norgren R.B. Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Caudate EMBL AFE64837.1.
[4]	"De novo assembly of the rhesus macaque transcriptome from NextGen mRNA sequences." Pandey S., Maudhoo M.D., Guda C., Ferguson B., Fox H., Norgren R.B. Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Thymus EMBL AFH33399.1.
[5]	"De novo assembly of the rhesus macaque transcriptome from NextGen mRNA sequences." Pandey S., Maudhoo M.D., Guda C., Ferguson B., Fox H., Norgren R.B. Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Testis EMBL AFI35838.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	JU321081 mRNA. Translation: AFE64837.1. JU476595 mRNA. Translation: AFH33399.1. JV045767 mRNA. Translation: AFI35838.1.
RefSeq	NP_001247945.1. NM_001261016.2.
UniGene	Mmu.30014.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMMUT00000005533; ENSMMUP00000005209; ENSMMUG00000003907.
GeneID	718948.
KEGG	mcc:718948.
Organism-specific databases
CTD	581.
Phylogenomic databases
GeneTree	ENSGT00530000062935.
KO	K02159.
OMA	GWIQEQG.
Gene expression databases
ArrayExpress	F6ZV96.
Family and domain databases
InterPro	IPR026304. BAX. IPR002475. Bcl2-like. IPR020717. Bcl2_BH1_motif_CS. IPR020726. Bcl2_BH2_motif_CS. IPR020728. Bcl2_BH3_motif_CS. IPR026298. Blc2_fam. [Graphical view]
PANTHER	PTHR11256. PTHR11256. 1 hit. PTHR11256:SF9. PTHR11256:SF9. 1 hit.
Pfam	PF00452. Bcl-2. 1 hit. [Graphical view]
PRINTS	PR01862. BCL2FAMILY.
PROSITE	PS50062. BCL2_FAMILY. 1 hit. PS01080. BH1. 1 hit. PS01258. BH2. 1 hit. PS01259. BH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	19985845.

Entry information

Entry name

F6ZV96_MACMU

Accession

Primary (citable) accession number: F6ZV96

Entry history

Integrated into UniProtKB/TrEMBL:	July 27, 2011
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)