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Protein

Mitogen-activated protein kinase

Gene

mapk12

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseSAAS annotation (EC:2.7.11.24SAAS annotation)
Gene namesi
Name:mapk12Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-956264.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Expressioni

Gene expression databases

BgeeiF6ZSI6.
ExpressionAtlasiF6ZSI6. baseline.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000000876.

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00550000074271.
KOiK04441.
OrthoDBiEOG7PCJGV.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6ZSI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGPRKGFY RQDINKTKWD VPVRYRDLAA VGSGAYGTVC SAQDRLTGER
60 70 80 90 100
VAIKKLLRPF QSLVHAKRAY RELRLLKHMK HENVISLLNV FTPDESMETF
110 120 130 140 150
QTFYLVMPFI AVDLSRVMRM QRLNHSTIVY LLYQILRGLQ YIHAAGIVHR
160 170 180 190 200
DLKPSNLGVN EDYELKILDF GLARPTEFEM TGYVVTRWYR APEVILNWMH
210 220 230 240 250
YNHTVDIWSV GCILAEMITG KVLFPGGDYF DELNKIIEVT GSPQPSLINK
260 270 280 290 300
MESSHAQDYV KMLPKKQKKN FKELFPTMSA VETDLLEKML DLDPGTRVNA
310 320 330 340 350
TEALAHPYLE EYNDSDPDPT ADKYDDSFES LDLNVHEWKS LSHMEIMTFE

PMKPSQAST
Length:359
Mass (Da):41,409
Last modified:July 27, 2011 - v1
Checksum:iF3870457119F2215
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01080393 Genomic DNA. No translation available.
AAMC01080394 Genomic DNA. No translation available.
AAMC01080395 Genomic DNA. No translation available.
RefSeqiXP_002938433.1. XM_002938387.2.
UniGeneiStr.52448.

Genome annotation databases

EnsembliENSXETT00000064704; ENSXETP00000059316; ENSXETG00000000409.
GeneIDi100145045.
KEGGixtr:100145045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01080393 Genomic DNA. No translation available.
AAMC01080394 Genomic DNA. No translation available.
AAMC01080395 Genomic DNA. No translation available.
RefSeqiXP_002938433.1. XM_002938387.2.
UniGeneiStr.52448.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000000876.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000064704; ENSXETP00000059316; ENSXETG00000000409.
GeneIDi100145045.
KEGGixtr:100145045.

Organism-specific databases

CTDi6300.
XenbaseiXB-GENE-956264.

Phylogenomic databases

GeneTreeiENSGT00550000074271.
KOiK04441.
OrthoDBiEOG7PCJGV.

Gene expression databases

BgeeiF6ZSI6.
ExpressionAtlasiF6ZSI6. baseline.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF6ZSI6_XENTR
AccessioniPrimary (citable) accession number: F6ZSI6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: July 22, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.