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Protein
Submitted name:

Natural resistance-associated macrophage protein 2

Gene

Slc11a2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. cadmium ion transmembrane transporter activity Source: MGI
  2. cobalt ion transmembrane transporter activity Source: MGI
  3. copper ion transmembrane transporter activity Source: MGI
  4. ferrous iron transmembrane transporter activity Source: MGI
  5. hydrogen ion transmembrane transporter activity Source: MGI
  6. inorganic cation transmembrane transporter activity Source: MGI
  7. iron ion transmembrane transporter activity Source: MGI
  8. lead ion transmembrane transporter activity Source: MGI
  9. manganese ion transmembrane transporter activity Source: MGI
  10. nickel cation transmembrane transporter activity Source: MGI
  11. solute:proton symporter activity Source: MGI
  12. vanadium ion transmembrane transporter activity Source: MGI

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  2. cadmium ion transmembrane transport Source: MGI
  3. cation transmembrane transport Source: MGI
  4. cellular response to oxidative stress Source: MGI
  5. cobalt ion transport Source: MGI
  6. copper ion transmembrane transport Source: MGI
  7. copper ion transport Source: MGI
  8. dendrite morphogenesis Source: MGI
  9. erythrocyte development Source: MGI
  10. ferrous iron import Source: MGI
  11. ferrous iron transport Source: MGI
  12. heme biosynthetic process Source: MGI
  13. hydrogen ion transmembrane transport Source: GOC
  14. iron ion transmembrane transport Source: GOC
  15. iron ion transport Source: MGI
  16. lead ion transport Source: MGI
  17. learning or memory Source: MGI
  18. manganese ion transmembrane transport Source: MGI
  19. manganese ion transport Source: MGI
  20. multicellular organismal iron ion homeostasis Source: MGI
  21. nickel cation transmembrane transport Source: MGI
  22. nickel cation transport Source: MGI
  23. porphyrin-containing compound biosynthetic process Source: MGI
  24. porphyrin-containing compound metabolic process Source: MGI
  25. proton transport Source: MGI
  26. vanadium ion transport Source: MGI
  27. zinc ion transmembrane transport Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Natural resistance-associated macrophage protein 2Imported
Gene namesi
Name:Slc11a2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1345279. Slc11a2.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: MGI
  2. apical plasma membrane Source: MGI
  3. basal part of cell Source: MGI
  4. brush border Source: MGI
  5. cell surface Source: MGI
  6. cytoplasm Source: MGI
  7. cytoplasmic vesicle Source: MGI
  8. early endosome Source: MGI
  9. endomembrane system Source: MGI
  10. endosome Source: MGI
  11. integral component of plasma membrane Source: MGI
  12. late endosome Source: MGI
  13. late endosome membrane Source: MGI
  14. lysosomal membrane Source: MGI
  15. lysosome Source: MGI
  16. membrane Source: MGI
  17. nucleus Source: MGI
  18. paraferritin complex Source: MGI
  19. perinuclear region of cytoplasm Source: MGI
  20. plasma membrane Source: MGI
  21. recycling endosome Source: MGI
  22. trans-Golgi network Source: MGI
  23. vacuole Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiF6ZM31.
ExpressionAtlasiF6ZM31. baseline and differential.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000006526.

Family and domain databases

InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.

Sequencei

Sequence statusi: Fragment.

F6ZM31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
INVFVVSVFA EAFFEKTNKQ VVEVCKNNSS PHADLFPSDN STLAVDIYKG
60 70 80 90 100
GVVLGCYFGP AALYIWAVGI LAAGQSSTMT GTYSGQFVME GFLNLKWSRF
110 120 130 140 150
ARVILTRSIA IIPTLLVAVF QDVEHLTGMN DFLNVLQSLQ LPFALIPILT
160 170 180 190 200
FTSLRPVMSE FSNGIGWRIA GGILVLIVCS INMYFVVVYV QELGHVALYV
210 220
VAAVVSVAYL TFVFYLVSPV
Length:220
Mass (Da):24,052
Last modified:July 27, 2011 - v1
Checksum:i648822D7F428A22F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139571 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000124324; ENSMUSP00000114702; ENSMUSG00000023030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139571 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000124324; ENSMUSP00000114702; ENSMUSG00000023030.

Organism-specific databases

MGIiMGI:1345279. Slc11a2.

Phylogenomic databases

GeneTreeiENSGT00390000006526.

Miscellaneous databases

ChiTaRSiSlc11a2. mouse.
NextBioi35558775.
SOURCEiSearch...

Gene expression databases

BgeeiF6ZM31.
ExpressionAtlasiF6ZM31. baseline and differential.

Family and domain databases

InterProiIPR001046. NRAMP_fam.
[Graphical view]
PANTHERiPTHR11706. PTHR11706. 1 hit.
PfamiPF01566. Nramp. 1 hit.
[Graphical view]
PRINTSiPR00447. NATRESASSCMP.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF6ZM31_MOUSE
AccessioniPrimary (citable) accession number: F6ZM31
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.