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F6ZFR0 (MTD2L_CALJA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2
Alternative name(s):
NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein
Short name=MTHFD2-like

Including the following 2 domains:

  1. NAD-dependent methylenetetrahydrofolate dehydrogenase
    EC=1.5.1.15
  2. Methenyltetrahydrofolate cyclohydrolase
    EC=3.5.4.9
Gene names
Name:MTHFD2L
OrganismCallithrix jacchus (White-tufted-ear marmoset) [Reference proteome]
Taxonomic identifier9483 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH. HAMAP-Rule MF_01576

5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. HAMAP-Rule MF_01576

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01576

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01576

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity HAMAP-Rule MF_01576.

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 HAMAP-Rule MF_01576
PRO_0000413327

Sequences

Sequence LengthMass (Da)Tools
F6ZFR0 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: 0A425A0D6AF2797C

FASTA34737,342
        10         20         30         40         50         60 
MTVPARGFLL LRGRLGRVPA LGRSTAPPVR APGGPRSAFR GFRSSGVRHE AVIISGTEMA 

        70         80         90        100        110        120 
KHIQKEIKQG VESWISLGNR RPHLSIILVG DNPASHTYVR NKIRAASAVG ICSELILKPK 

       130        140        150        160        170        180 
DVSQEELLDI TDQLNMDPRV SGILVQLPLP DHVDERMICN GIAPEKDVDG FHIINIGRLC 

       190        200        210        220        230        240 
LDQHSLIPAT ASAVWEIITR TGIQTFGKNV VVAGRSKNVG MPIAMLLHTD GEHERPGGDA 

       250        260        270        280        290        300 
TVTIAHRYTP KEQLKTHTQL ADVIIVAAGI PKLITSDMVK EGAAVIDVGI NYVHDPVTGK 

       310        320        330        340 
TKLVGDVDFE AVKKKAGFIT PVPGGVGPMT VAMLLKNTLL AAKKIIY 

« Hide

References

[1]Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ACFV01093585 Genomic DNA. No translation available.
ACFV01093586 Genomic DNA. No translation available.
ACFV01093587 Genomic DNA. No translation available.
ACFV01093588 Genomic DNA. No translation available.
RefSeqXP_002745776.1. XM_002745730.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCJAT00000026964; ENSCJAP00000025515; ENSCJAG00000013883.
GeneID100389511.

Organism-specific databases

CTD441024.

Phylogenomic databases

GeneTreeENSGT00750000117401.
OMAMAGNDES.
OrthoDBEOG7CG70C.
TreeFamTF323998.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01576. THF_DHG_CYH.
InterProIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSPR00085. THFDHDRGNASE.
ProtoNetSearch...

Entry information

Entry nameMTD2L_CALJA
AccessionPrimary (citable) accession number: F6ZFR0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 27, 2011
Last modified: May 14, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways