Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2

Gene

MTHFD2L

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH.
5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.

Cofactori

Mg2+By similarity

Pathwayi

GO - Molecular functioni

  1. methenyltetrahydrofolate cyclohydrolase activity Source: UniProtKB-EC
  2. methylenetetrahydrofolate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  3. methylenetetrahydrofolate dehydrogenase (NADP+) activity Source: InterPro

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. histidine biosynthetic process Source: UniProtKB-KW
  3. methionine biosynthetic process Source: UniProtKB-KW
  4. purine nucleotide biosynthetic process Source: UniProtKB-KW
  5. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis, Methionine biosynthesis, One-carbon metabolism, Purine biosynthesis

Keywords - Ligandi

Magnesium, NAD

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2
Alternative name(s):
NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein
Short name:
MTHFD2-like
Including the following 2 domains:
NAD-dependent methylenetetrahydrofolate dehydrogenase (EC:1.5.1.15)
Methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9)
Gene namesi
Name:MTHFD2L
OrganismiCallithrix jacchus (White-tufted-ear marmoset)
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
ProteomesiUP000008225 Componenti: Chromosome 3

Subcellular locationi

Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2PRO_0000413327Add
BLAST

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00750000117401.
InParanoidiF6ZFR0.
KOiK13403.
OMAiCLTPANI.
OrthoDBiEOG7CG70C.
TreeFamiTF323998.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01576. THF_DHG_CYH.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamiPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSiPR00085. THFDHDRGNASE.

Sequencei

Sequence statusi: Complete.

F6ZFR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVPARGFLL LRGRLGRVPA LGRSTAPPVR APGGPRSAFR GFRSSGVRHE
60 70 80 90 100
AVIISGTEMA KHIQKEIKQG VESWISLGNR RPHLSIILVG DNPASHTYVR
110 120 130 140 150
NKIRAASAVG ICSELILKPK DVSQEELLDI TDQLNMDPRV SGILVQLPLP
160 170 180 190 200
DHVDERMICN GIAPEKDVDG FHIINIGRLC LDQHSLIPAT ASAVWEIITR
210 220 230 240 250
TGIQTFGKNV VVAGRSKNVG MPIAMLLHTD GEHERPGGDA TVTIAHRYTP
260 270 280 290 300
KEQLKTHTQL ADVIIVAAGI PKLITSDMVK EGAAVIDVGI NYVHDPVTGK
310 320 330 340
TKLVGDVDFE AVKKKAGFIT PVPGGVGPMT VAMLLKNTLL AAKKIIY
Length:347
Mass (Da):37,342
Last modified:July 26, 2011 - v1
Checksum:i0A425A0D6AF2797C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFV01093585 Genomic DNA. No translation available.
ACFV01093586 Genomic DNA. No translation available.
ACFV01093587 Genomic DNA. No translation available.
ACFV01093588 Genomic DNA. No translation available.
RefSeqiXP_002745776.1. XM_002745730.2.

Genome annotation databases

EnsembliENSCJAT00000026964; ENSCJAP00000025515; ENSCJAG00000013883.
GeneIDi100389511.
KEGGicjc:100389511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFV01093585 Genomic DNA. No translation available.
ACFV01093586 Genomic DNA. No translation available.
ACFV01093587 Genomic DNA. No translation available.
ACFV01093588 Genomic DNA. No translation available.
RefSeqiXP_002745776.1. XM_002745730.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCJAT00000026964; ENSCJAP00000025515; ENSCJAG00000013883.
GeneIDi100389511.
KEGGicjc:100389511.

Organism-specific databases

CTDi441024.

Phylogenomic databases

GeneTreeiENSGT00750000117401.
InParanoidiF6ZFR0.
KOiK13403.
OMAiCLTPANI.
OrthoDBiEOG7CG70C.
TreeFamiTF323998.

Enzyme and pathway databases

UniPathwayiUPA00193.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01576. THF_DHG_CYH.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamiPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSiPR00085. THFDHDRGNASE.
ProtoNetiSearch...

Publicationsi

  1. Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMTD2L_CALJA
AccessioniPrimary (citable) accession number: F6ZFR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2011
Last sequence update: July 26, 2011
Last modified: January 6, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.