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F6ZFR0

- MTD2L_CALJA

UniProt

F6ZFR0 - MTD2L_CALJA

Protein

Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2

Gene

MTHFD2L

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH.
    5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. methenyltetrahydrofolate cyclohydrolase activity Source: UniProtKB-EC
    2. methylenetetrahydrofolate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    3. methylenetetrahydrofolate dehydrogenase (NADP+) activity Source: InterPro

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. histidine biosynthetic process Source: UniProtKB-KW
    3. methionine biosynthetic process Source: UniProtKB-KW
    4. purine nucleotide biosynthetic process Source: UniProtKB-KW
    5. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis, Methionine biosynthesis, One-carbon metabolism, Purine biosynthesis

    Keywords - Ligandi

    Magnesium, NAD

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2
    Alternative name(s):
    NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein
    Short name:
    MTHFD2-like
    Including the following 2 domains:
    NAD-dependent methylenetetrahydrofolate dehydrogenase (EC:1.5.1.15)
    Methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9)
    Gene namesi
    Name:MTHFD2L
    OrganismiCallithrix jacchus (White-tufted-ear marmoset)
    Taxonomic identifieri9483 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrix
    ProteomesiUP000008225: Chromosome 3

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2PRO_0000413327Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00750000117401.
    OMAiMAGNDES.
    OrthoDBiEOG7CG70C.
    TreeFamiTF323998.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01576. THF_DHG_CYH.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR000672. THF_DH/CycHdrlase.
    IPR020630. THF_DH/CycHdrlase_cat_dom.
    IPR020867. THF_DH/CycHdrlase_CS.
    IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
    [Graphical view]
    PfamiPF00763. THF_DHG_CYH. 1 hit.
    PF02882. THF_DHG_CYH_C. 1 hit.
    [Graphical view]
    PRINTSiPR00085. THFDHDRGNASE.

    Sequencei

    Sequence statusi: Complete.

    F6ZFR0-1 [UniParc]FASTAAdd to Basket

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    MTVPARGFLL LRGRLGRVPA LGRSTAPPVR APGGPRSAFR GFRSSGVRHE    50
    AVIISGTEMA KHIQKEIKQG VESWISLGNR RPHLSIILVG DNPASHTYVR 100
    NKIRAASAVG ICSELILKPK DVSQEELLDI TDQLNMDPRV SGILVQLPLP 150
    DHVDERMICN GIAPEKDVDG FHIINIGRLC LDQHSLIPAT ASAVWEIITR 200
    TGIQTFGKNV VVAGRSKNVG MPIAMLLHTD GEHERPGGDA TVTIAHRYTP 250
    KEQLKTHTQL ADVIIVAAGI PKLITSDMVK EGAAVIDVGI NYVHDPVTGK 300
    TKLVGDVDFE AVKKKAGFIT PVPGGVGPMT VAMLLKNTLL AAKKIIY 347
    Length:347
    Mass (Da):37,342
    Last modified:July 27, 2011 - v1
    Checksum:i0A425A0D6AF2797C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACFV01093585 Genomic DNA. No translation available.
    ACFV01093586 Genomic DNA. No translation available.
    ACFV01093587 Genomic DNA. No translation available.
    ACFV01093588 Genomic DNA. No translation available.
    RefSeqiXP_002745776.1. XM_002745730.1.

    Genome annotation databases

    EnsembliENSCJAT00000026964; ENSCJAP00000025515; ENSCJAG00000013883.
    GeneIDi100389511.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACFV01093585 Genomic DNA. No translation available.
    ACFV01093586 Genomic DNA. No translation available.
    ACFV01093587 Genomic DNA. No translation available.
    ACFV01093588 Genomic DNA. No translation available.
    RefSeqi XP_002745776.1. XM_002745730.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCJAT00000026964 ; ENSCJAP00000025515 ; ENSCJAG00000013883 .
    GeneIDi 100389511.

    Organism-specific databases

    CTDi 441024.

    Phylogenomic databases

    GeneTreei ENSGT00750000117401.
    OMAi MAGNDES.
    OrthoDBi EOG7CG70C.
    TreeFami TF323998.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01576. THF_DHG_CYH.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR000672. THF_DH/CycHdrlase.
    IPR020630. THF_DH/CycHdrlase_cat_dom.
    IPR020867. THF_DH/CycHdrlase_CS.
    IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
    [Graphical view ]
    Pfami PF00763. THF_DHG_CYH. 1 hit.
    PF02882. THF_DHG_CYH_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00085. THFDHDRGNASE.
    ProtoNeti Search...

    Publicationsi

    1. Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiMTD2L_CALJA
    AccessioniPrimary (citable) accession number: F6ZFR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3