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Protein
Submitted name:

Huntingtin

Gene

HTT

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
HuntingtinImported
Gene namesi
Name:HTTImported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000025884.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati920 – 950HEATPROSITE-ProRule annotationAdd BLAST31

Phylogenomic databases

eggNOGiENOG410IDZV. Eukaryota.
ENOG410XSEC. LUCA.
GeneTreeiENSGT00390000015863.
InParanoidiF6ZCK5.
OMAiPIRRKGK.
OrthoDBiEOG091G004G.
TreeFamiTF323608.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR000091. Huntingtin.
IPR028426. Huntingtin_fam.
IPR024613. Huntingtin_middle-repeat.
PANTHERiPTHR10170. PTHR10170. 1 hit.
PfamiView protein in Pfam
PF12372. DUF3652. 1 hit.
PRINTSiPR00375. HUNTINGTIN.
SUPFAMiSSF48371. SSF48371. 5 hits.
PROSITEiView protein in PROSITE
PS50077. HEAT_REPEAT. 1 hit.

Sequencei

Sequence statusi: Complete.

F6ZCK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLEKLMKA FESLKSPAGR RRGDRVTQQP QTRRDTRSLL RRDPPPLPPG
60 70 80 90 100
SRTWVFPGPP AGRGRASWEP VLKSPRRSPS PSPPFPVLTV KLKGLHLPKK
110 120 130 140 150
ELSATKKDRV NHCLTICENI VAQSVRNSPE FQKLLGIAME LFLLCSDDAE
160 170 180 190 200
SDVRMVADEC LNKVIKALMD SNLPRLQLEL YKEIKKNGAP RSLRAALWRF
210 220 230 240 250
AELAHLVRPQ KCSHRPYLVN LLPCLTRTSK RPEESVQETL AAAVPKIMAS
260 270 280 290 300
FGNFANDNEI KVLLKAFIAN LKSSSPTIRR TAAGSAVSIC QHSRRTHYFY
310 320 330 340 350
SWLLNVLLGL LVPVEDEHST LLILGVLLTL RYLVPLLQQQ VKDTSLKGSF
360 370 380 390 400
GVTRKEMEVS PSAEQLIQVY ELTLHHTQHQ DHNVVTGALE LLQQLFRTPP
410 420 430 440 450
PELLQALTTV GGIRQLTEAK DESGGRSRSG SIVELIAGGG SSCSPVLSRK
460 470 480 490 500
QKGKVLLGEE EALEDDSESR SDVSSSAFAA SVKDEISGEL TASSGVSTPG
510 520 530 540 550
SAGHDIITEQ PRSQHTLQAD SVDLAGCDLT SSATDGDEED ILSHSSSQVS
560 570 580 590 600
AVPSDPAMDL NDGTQASSPI SDSSQTTTEG PDSAVTPSDS SEIVLDGADN
610 620 630 640 650
QYLGPQIGQP QDEDEEATSV LPDEASEAFR NSSMALQQAH LLKNMSHSRQ
660 670 680 690 700
PSDSSVDKFV SRDEATESGD QESKPCRIKG DIGQSTDDDS APLVHCVRLL
710 720 730 740 750
SASFLLTGGK NVLVPDRDVR VSVKALALSC VGAAVALHPE SFFSKLYKVP
760 770 780 790 800
LDTADYPEEQ YVSDILNYID HGDPQVRGAT AILCGTLVCS ILSRSRFHVG
810 820 830 840 850
EWMGTIRTLT GNTFSLADCV PLLRKTLKDE SSVTCKLACT AVRHCVMSLC
860 870 880 890 900
SSSYSELGLQ LLIDLLTLRN SSYWLVRTEL LETLAEIDFR LVSFLEAKAE
910 920 930 940 950
NLHRGAHHYT GLLTLQERVL TSVVIHLLGD EDPRVRHVAA ASLIRLVPKL
960 970 980 990 1000
FYKCDQGQAD PVVAVARDQS SVYLKLLMHE TQPPSHFSVS TITRIYRGYN
1010 1020 1030 1040 1050
LLPSIIDVTM ENNLSRVIAA VSHELITSTT RALTFGCCEA LCLLSTAFPV
1060 1070 1080 1090 1100
CIWSLGWHCG VPPLSASDEC RKSCTIGMAT MILTLLSSAW FPLDLSAHQD
1110 1120 1130 1140 1150
ALILAGNLLA ASAPKSLRSS WTSEEEANPA ATKQEEVWPA LGDRALVPMV
1160 1170 1180 1190 1200
EQLFSHLLKV INICAHVLDD VAPGPAIKAA LPSLTNPPSL SPIRRKGKEK
1210 1220 1230 1240 1250
EPGEQASVPL SPKKGSEASA ASRQSDTSGP VTTSKSSSLG SFYHLPSYLK
1260 1270 1280 1290 1300
LHDVLKATHA NYKVTLDLQN STEKFGGFLR SALDVLSQIL ELATLQDIGK
1310 1320 1330 1340 1350
CVEEILGYLK SCFSREPMMA TVCVQQLLKT LFGTNLASQF DGLSSNPSKS
1360 1370 1380 1390 1400
QGRVQRLGSS SVRPGLYHYC FMAPYTHFTQ ALADASLRNM VQAEQEHDTS
1410 1420 1430 1440 1450
GWFDVLQKVS TQLKTNLTSV TKNRADKNAI HNHIRLFEPL VIKALKQYTT
1460 1470 1480 1490 1500
TTSVQLQKQV LDLLAQLVQL RVNYCLLDSD QVFIGFVLKQ FEYIEVGQFR
1510 1520 1530 1540 1550
ESEAIIPNIF FFLVLLSYER YHSKQIIGIP KIIQLCDGIM ASGRKAVTHA
1560 1570 1580 1590 1600
IPALQPIVHD LFVLRGANKA DAGKELETQK EVVVSMLLRL IQYHQVLEMF
1610 1620 1630 1640 1650
ILVLQQCHKE NEDKWKRLSR QIADIILPML AKQQMHIDSH EALGVLNTLF
1660 1670 1680 1690 1700
EILAPSSLRP VDMLLRSMFV TPNTMASVST VQLWISGILA ILRVLISQST
1710 1720 1730 1740 1750
EDIVLSRIQE LTFSPYLISC PVISRLRDGD SNSALEEHSE GKQIKTLPEE
1760 1770 1780 1790 1800
TFSRFLLQLV GILLEDIVTK QLKVEMSEQQ HTFYCQELGT LLMCLIHIFK
1810 1820 1830 1840 1850
SGMFRRITAA ATRLFRSDGC GGSFYTLESL NLRARSMITT HPTLVLLWCQ
1860 1870 1880 1890 1900
ILLLVNHTDY RWWAEVQQTP KRHSLSSTKL LSPQMSGEEE DSDLAAKLGM
1910 1920 1930 1940 1950
CNREIVRRGA LILFCDYVCQ NLHDSEHLTW LIVNHIQDLI SLSHEPPVQD
1960 1970 1980 1990 2000
FISAVHRNSA ASGLFIQAIQ SRCENLSTPT TLKKTLQCLE GIHLSQSGAV
2010 2020 2030 2040 2050
LTLYVDRLLC TPFRVLARMV DILACRRVEM LLAANLQSSM AQLPMEELNR
2060 2070 2080 2090 2100
IQEYLQSSGL AQRHQRLYSL LDRFRLSTLQ DSLSPSPPVS SHPLDGDGHV
2110 2120 2130 2140 2150
SLETVSPDKD WYIHLVKSQC WTRSDSALLE GAELVNRIPA EDMSAFMMNS
2160 2170 2180 2190 2200
EFNISLLAPC LSLGMSEISG GQKSPLFEAA REVTLARVSG TVQRLPAVHH
2210 2220 2230 2240 2250
VFQPHLPAEP AAYWSSDDLF GIKAIIVLCT SKYTVKAVAR SPSHLHLQCH
2260 2270 2280 2290 2300
MDPDFRDLNN NHLEALSWHL IHEQIPLSLD LQAGLDCCCL ALQLPGLWSV
2310 2320 2330 2340 2350
ISSTEFVTHA CSLIHCVHFI LEAVAVQPGE QLLSPERRRN TPKAIREEEE
2360 2370 2380 2390 2400
VDANTQNPKY ITAACEMVAE MVESLQSVLA LGHKRNSSVP AFLTSVLRNI
2410 2420 2430 2440 2450
IVSLARLPLV NSYTRVPPLV WKLGWSPKPG GEFGTAFPEI PVEFLQEKEV
2460 2470 2480 2490 2500
CGIPGYRARF LGWTSRTQFE ETWATLLGVL VTQPLVMEQE ESPPEEDTER
2510 2520 2530 2540 2550
TQINVLAVQA ITSLVLSAMT VPVAGNPAVS CLEQQPRNKP LKALDTRFGR
2560 2570 2580 2590 2600
KLSIIRGIVE QEIQAMVSKR ENIATHHLYQ AWDPVPSLSP ATTGALISHE
2610 2620 2630 2640 2650
KLLLQTNPER ELGSMSYKLG QVSIHSVWLG NNITPLTDTP APSSPPTSPV
2660 2670 2680 2690 2700
NSRKHRAGVD IHSCSQFLLE LYSRWILPSS SARRTPAILI SEVVRSLLVV
2710 2720 2730 2740 2750
SDLFTERSQF ELMYVTLTEL RRVHPSEDEI LAQYLVPTTC KAAAVLGMDK
2760 2770 2780 2790 2800
AVAEPVSRLL ESTLRSSHLP SRVGALHGIL YVLECDLLDD TAKQLIPVIS
2810 2820 2830 2840 2850
DYLLSSLKGL AHCVNTHSQQ HVLVMCATAF YLIENYPLDV GPEFSASIIQ
2860 2870 2880 2890 2900
MCGVMLSGSE ESTPSIIYHC ALRGLERLLL SEQLSRLDAE SLVKLSVDRV
2910 2920 2930 2940 2950
NVHSPHRAMA ALGLMLTCMY TGKEKISPGR TSDPNPAAPD SESVIVAMER
2960 2970 2980 2990 3000
VSVLFDRIRK GFPCEARVVA RILPQFLDDF FPPQDIMNKV IGEFLSNQQP
3010 3020 3030 3040 3050
YPQFMATVVY KVFQTLHSTG QSSMVRDWVM LSLSNFTQRT PVAMAMWSLS
3060 3070 3080 3090 3100
CFFVSASTSP WVAAILPHVI SRMGKLEQVD VNLFCLVATD FYRHQIEEEL
3110 3120 3130
DRRAFQSVFE MVAAPGSPYH RLLTCLRNVH KVSTC
Length:3,135
Mass (Da):346,790
Last modified:July 27, 2011 - v1
Checksum:i853BE48086505199
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFV01137879 Genomic DNA. No translation available.
ACFV01137880 Genomic DNA. No translation available.
ACFV01137881 Genomic DNA. No translation available.
ACFV01137882 Genomic DNA. No translation available.
ACFV01137883 Genomic DNA. No translation available.
ACFV01137884 Genomic DNA. No translation available.
ACFV01137885 Genomic DNA. No translation available.
ACFV01137886 Genomic DNA. No translation available.
ACFV01137887 Genomic DNA. No translation available.
ACFV01137888 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSCJAT00000027350; ENSCJAP00000025884; ENSCJAG00000014069.

Similar proteinsi

Entry informationi

Entry nameiF6ZCK5_CALJA
AccessioniPrimary (citable) accession number: F6ZCK5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 25, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported