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Protein

Nuclear factor 1

Gene

NFIB

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi2 – 195CTF/NF-IPROSITE-ProRule annotationAdd BLAST194

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorPROSITE-ProRule annotation, DNA-bindingPROSITE-ProRule annotation
Biological processDNA replicationPROSITE-ProRule annotation, Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor 1UniRule annotation
Gene namesi
Name:NFIBImported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Interactioni

Subunit structurei

Binds DNA as a homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000022348.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 195CTF/NF-IInterPro annotationAdd BLAST194

Sequence similaritiesi

Belongs to the CTF/NF-I family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3663. Eukaryota.
ENOG410Y16G. LUCA.
GeneTreeiENSGT00390000009905.
InParanoidiF6Z9H8.
TreeFamiTF313889.

Family and domain databases

InterProiView protein in InterPro
IPR000647. CTF/NFI.
IPR020604. CTF/NFI_DNA-bd-dom.
IPR019739. CTF/NFI_DNA-bd_CS.
IPR019548. CTF/NFI_DNA-bd_N.
IPR003619. MAD_homology1_Dwarfin-type.
PANTHERiPTHR11492. PTHR11492. 2 hits.
PfamiView protein in Pfam
PF00859. CTF_NFI. 1 hit.
PF03165. MH1. 1 hit.
PF10524. NfI_DNAbd_pre-N. 1 hit.
SMARTiView protein in SMART
SM00523. DWA. 1 hit.
PROSITEiView protein in PROSITE
PS00349. CTF_NFI_1. 1 hit.
PS51080. CTF_NFI_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F6Z9H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMYSPICLTQ DEFHPFIEAL LPHVRAIAYT WFNLQARKRK YFKKHEKRMS
60 70 80 90 100
KDEERAVKDE LLSEKPEIKQ KWASRLLAKL RKDIRQEYRE DFVLTVTGKK
110 120 130 140 150
HPCCVLSNPD QKGKIRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER
160 170 180 190 200
LMKSPHCTNP ALCVQPHHIT VSVKELDLFL AYYVQEQDSG QSGSPSHNDP
210 220 230 240 250
AKNPPGYLED SFVKSGVFNV SELVRVSRTP ITQGTGVNFP IGEIPSQPYY
260 270 280 290 300
HDMNSGVNLQ RSLSSPPSSK RPKTISIDEN MEPSPTGDFY PSPNSPAAGS
310 320 330 340 350
RTWHERDQDM SSPTTMKKPE KPLFSSASPQ DSSPRLSTFP QHHHPGIPGV
360 370 380 390 400
AHSVISTRTP PPPSPLPFPT QAILPPAPSS YFSHPTIRYP PHLNPQDTLK
410 420 430 440
NYVPSYDPSS PQTSQLRICD WTMNQNGRHL YPSTSEDTLG ITWQRS
Length:446
Mass (Da):50,524
Last modified:July 27, 2011 - v1
Checksum:iC02F7BEDE03063D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFV01015739 Genomic DNA. No translation available.
ACFV01015740 Genomic DNA. No translation available.
ACFV01015741 Genomic DNA. No translation available.
ACFV01015742 Genomic DNA. No translation available.
ACFV01015743 Genomic DNA. No translation available.
ACFV01015744 Genomic DNA. No translation available.
ACFV01015745 Genomic DNA. No translation available.
ACFV01015746 Genomic DNA. No translation available.
ACFV01015747 Genomic DNA. No translation available.
ACFV01015748 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSCJAT00000023628; ENSCJAP00000022348; ENSCJAG00000012155.

Similar proteinsi

Entry informationi

Entry nameiF6Z9H8_CALJA
AccessioniPrimary (citable) accession number: F6Z9H8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 25, 2017
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported