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F6Z5C0

- UBP15_XENTR

UniProt

F6Z5C0 - UBP15_XENTR

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Protein

Ubiquitin carboxyl-terminal hydrolase 15

Gene

usp15

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs, thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of tgfbr1, leading to an enhanced TGF-beta signal (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei297 – 2971NucleophilePROSITE-ProRule annotation
Active sitei891 – 8911Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. BMP signaling pathway Source: UniProtKB
  2. monoubiquitinated protein deubiquitination Source: UniProtKB
  3. pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  4. protein deubiquitination Source: UniProtKB
  5. transforming growth factor beta receptor signaling pathway Source: UniProtKB
  6. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_204688. Downregulation of TGF-beta receptor signaling.

Protein family/group databases

MEROPSiC19.022.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 15 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 15
Ubiquitin thioesterase 15
Ubiquitin-specific-processing protease 15
Gene namesi
Name:usp15
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1008519. usp15.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 982982Ubiquitin carboxyl-terminal hydrolase 15PRO_0000420491Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000046428.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 118112DUSPPROSITE-ProRule annotationAdd
BLAST
Domaini288 – 933646USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 DUSP domain.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Phylogenomic databases

InParanoidiF6Z5C0.
KOiK11835.

Family and domain databases

Gene3Di3.30.2230.10. 1 hit.
InterProiIPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028135. Ub_USP-typ.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF06337. DUSP. 1 hit.
PF14836. Ubiquitin_3. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00695. DUSP. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51283. DUSP. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: F6Z5C0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEGGVVDLE TQRSEVSALL KTPLRRGDTW YLIDSRWFKQ WKKYVGFDSW
60 70 80 90 100
DKYQMGDQNV YPGPIDNSGL LKDTDTQSLK EHLIDELDYI LLPTEGWNKL
110 120 130 140 150
VSWYSVVESQ QPIARKVVEQ GMFVKHCKVE VYLTELKLCE NGNMNNVVTR
160 170 180 190 200
RFSKADTIDM IEKEMRTIFS IPDEKETRLW NKYMSNTFEP LNKPESTIQD
210 220 230 240 250
AGLYQGQMLV IEQKNQEGQW PRGSMPKSSG IPNFSTLPKI SPSSLSNNYN
260 270 280 290 300
NFNSRIMKNS NYCLPSYAAY KNYEYSEPGR HNEQPGLCGL SNLGNTCFMN
310 320 330 340 350
SAIQCLSNTP PLTEYFLNDK YQDELNMDNP LGMRGEIAKS YAELIKQMWS
360 370 380 390 400
GKYSYVTPRA FKTQVGRFAP QFSGYQQQDC QELLAFLLDG LHEDLNRIRK
410 420 430 440 450
KPYIQLKDAD GRPDKVVAEE AWENHIKRND SIIVDIFHGL FKSTLVCPEC
460 470 480 490 500
SKISVTFDPF CYLTLPLPMK KERALEVYLV RMDPLAKPMQ YKVIVPKIGN
510 520 530 540 550
IMDLCTALSS LSGIAPEKMV VTDIYNHRFH RIFAMDENLS SIMERDDIYV
560 570 580 590 600
FETSINRTED TEQVIIPVYL REKFRHTSYS HHHGSTLFGQ PFLITVPRNI
610 620 630 640 650
TEDKLYNLLL LRMCRYVKAT NDTEENDGSL HCNKEHTVNG NGPNGIHEEG
660 670 680 690 700
SPSEMETDEP DDESSQDQEL PSENENSQSE DSVGGDNDSE NGLCTEDTCK
710 720 730 740 750
GQSVTGQKKR LFTFQFSNLG SSDITYIKDD TKYIRFDERQ LRLDERSYLA
760 770 780 790 800
LDWDPKLKKK FFDENAAEDF EKHESVDFTP QKKAFMKLKD CIELFTTKEK
810 820 830 840 850
LGAEDPWYCP NCKEHQQATK KLDLWSLPPV LVVHLKRFSY SRYMRDKLDT
860 870 880 890 900
LVDFPISDLD MSTFLINPNA GPCCYNLIAV SNHYGGMGGG HYTAFAKNKD
910 920 930 940 950
DGKWYYFDDS SVSTASEEQI VSKAAYVLFY QRQDTITGTG FFPLDKEVKQ
960 970 980
GASAATGAPH ESDEESNEDE NDIENENCMH TN
Length:982
Mass (Da):112,689
Last modified:November 28, 2012 - v2
Checksum:i2B4F415FE1199C24
GO
Isoform 2 (identifier: F6Z5C0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-256: KSSGIPNFSTLPKISPSSLSNNYNNFNSRI → N

Show »
Length:953
Mass (Da):109,536
Checksum:iE87676D21A7742C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti626 – 6261N → I in AAI66318. 1 PublicationCurated
Sequence conflicti978 – 9825CMHTN → YLEKL in AAI66318. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei227 – 25630KSSGI…FNSRI → N in isoform 2. 1 PublicationVSP_044519Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAMC01103598 Genomic DNA. No translation available.
AAMC01103599 Genomic DNA. No translation available.
AAMC01103600 Genomic DNA. No translation available.
AAMC01103601 Genomic DNA. No translation available.
BC166318 mRNA. Translation: AAI66318.1.
RefSeqiNP_001121498.1. NM_001128026.1.
UniGeneiStr.21191.

Genome annotation databases

GeneIDi100158604.
KEGGixtr:100158604.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAMC01103598 Genomic DNA. No translation available.
AAMC01103599 Genomic DNA. No translation available.
AAMC01103600 Genomic DNA. No translation available.
AAMC01103601 Genomic DNA. No translation available.
BC166318 mRNA. Translation: AAI66318.1 .
RefSeqi NP_001121498.1. NM_001128026.1.
UniGenei Str.21191.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000046428.

Protein family/group databases

MEROPSi C19.022.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100158604.
KEGGi xtr:100158604.

Organism-specific databases

CTDi 9958.
Xenbasei XB-GENE-1008519. usp15.

Phylogenomic databases

InParanoidi F6Z5C0.
KOi K11835.

Enzyme and pathway databases

Reactomei REACT_204688. Downregulation of TGF-beta receptor signaling.

Family and domain databases

Gene3Di 3.30.2230.10. 1 hit.
InterProi IPR006615. Pept_C19_DUSP.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028135. Ub_USP-typ.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF06337. DUSP. 1 hit.
PF14836. Ubiquitin_3. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view ]
SMARTi SM00695. DUSP. 1 hit.
[Graphical view ]
SUPFAMi SSF143791. SSF143791. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS51283. DUSP. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.

Entry informationi

Entry nameiUBP15_XENTR
AccessioniPrimary (citable) accession number: F6Z5C0
Secondary accession number(s): B2GUK6, F6ZNA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: November 28, 2012
Last modified: October 29, 2014
This is version 23 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3