F6Z5C0 (UBP15_XENTR) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 29, 2013.
Version 14.
History...
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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ubiquitin carboxyl-terminal hydrolase 15 EC=3.4.19.12 Alternative name(s): Deubiquitinating enzyme 15 Ubiquitin thioesterase 15 Ubiquitin-specific-processing protease 15 | ||
| Gene names |
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| Organism | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome] | ||
| Taxonomic identifier | 8364 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Protein attributes
| Sequence length | 982 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs, thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of tgfbr1, leading to an enhanced TGF-beta signal By similarity. |
| Catalytic activity | Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). |
| Subcellular location | |
| Sequence similarities | Belongs to the peptidase C19 family. Contains 1 DUSP domain. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: F6Z5C0-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: F6Z5C0-2) The sequence of this isoform differs from the canonical sequence as follows: 227-256: KSSGIPNFSTLPKISPSSLSNNYNNFNSRI → N |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 982 | 982 | Ubiquitin carboxyl-terminal hydrolase 15 | PRO_0000420491 | |||||
Regions | |||||||||
| Domain | 7 – 118 | 112 | DUSP | ||||||
Sites | |||||||||
| Active site | 297 | 1 | Nucleophile By similarity | ||||||
| Active site | 891 | 1 | Proton acceptor By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 227 – 256 | 30 | KSSGI…FNSRI → N in isoform 2. | VSP_044519 | |||||
Experimental info | |||||||||
| Sequence conflict | 626 | 1 | N → I in AAI66318. Ref.2 | ||||||
| Sequence conflict | 978 – 982 | 5 | CMHTN → YLEKL in AAI66318. Ref.2 | ||||||
Sequences
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References
| [1] | "The genome of the Western clawed frog Xenopus tropicalis." Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R., Gerhard D.S.  Rokhsar D.S.Science 328:633-636(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | NIH - Xenopus Gene Collection (XGC) project Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Embryo. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AAMC01103598 Genomic DNA. No translation available. AAMC01103599 Genomic DNA. No translation available. AAMC01103600 Genomic DNA. No translation available. AAMC01103601 Genomic DNA. No translation available. BC166318 mRNA. Translation: AAI66318.1. |
| RefSeq | NP_001121498.1. NM_001128026.1. |
| UniGene | Str.21191. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 8364.ENSXETP00000046428. |
Protein family/group databases | |
| MEROPS | C19.022. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 100158604. |
| KEGG | xtr:100158604. |
Organism-specific databases | |
| CTD | 9958. |
| Xenbase | XB-GENE-1008519. usp15. |
Phylogenomic databases | |
| KO | K11835. |
Family and domain databases | |
| InterPro | IPR006615. Pept_C19_DUSP. IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view] |
| Pfam | PF06337. DUSP. 1 hit. PF00443. UCH. 1 hit. [Graphical view] |
| SMART | SM00695. DUSP. 1 hit. [Graphical view] |
| PROSITE | PS51283. DUSP. 1 hit. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | UBP15_XENTR | ||||||||
| Accession | Primary (citable) accession number: F6Z5C0 Secondary accession number(s): B2GUK6, F6ZNA0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |