F6YXZ8 (F6YXZ8_HORSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aspartate aminotransferase RuleBase RU000480
EC=2.6.1.1 RuleBase RU000480

Gene names

Name:

GOT2 Ensembl ENSECAP00000014550

Organism

Equus caballus (Horse) [Reference proteome] Ensembl ENSECAP00000014550

Taxonomic identifier

9796 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › Equus

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. RuleBase RU000480
Cofactor	Pyridoxal phosphate By similarity. RuleBase RU000479
Subunit structure	Homodimer By similarity. RuleBase RU000480
Miscellaneous	In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes By similarity. RuleBase RU000480
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. RuleBase RU000479
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSECAP00000014550

Ontologies

Keywords
Ligand	Pyridoxal phosphate RuleBase RU000479
Molecular function	Aminotransferase RuleBase RU000480 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aspartate biosynthetic process Inferred from electronic annotation. Source: Compara aspartate catabolic process Inferred from electronic annotation. Source: Compara fatty acid transport Inferred from electronic annotation. Source: Compara glutamate catabolic process to 2-oxoglutarate Inferred from electronic annotation. Source: Compara glutamate catabolic process to aspartate Inferred from electronic annotation. Source: Compara oxaloacetate metabolic process Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F6YXZ8 [UniParc]. Last modified July 27, 2011. Version 1. Checksum: 36DC576F320722DA	FASTA	430	47,340
	10 20 30 40 50 60 MALLHSGRVL SGVASAFHPG LAAAASARAS SWWAHVEMGP PDPILGVTEA YKRDTNSKKM 70 80 90 100 110 120 NLGVGAYRDD NGKPYVLPSV RKAEAQIAAK NLDKEYLPIG GLAEFCKASA ELALGENSEA 130 140 150 160 170 180 LKSGRYVTVQ SISGTGALRI GANFLQRFFK FSRDVFLPKP SWGNHTPIFR DAGLQLHAYR 190 200 210 220 230 240 YYDPKTCGFD VTGALEDISK IPQQSIILLH ACAHNPTGVD PRPEQWKEIA TLVKKNNLFA 250 260 270 280 290 300 FFDMAYQGFA SGDGDKDAWA VRYFIEQGIN VCLCQSYAKN MGLYGERVGA FTMVCKDADE 310 320 330 340 350 360 AKRVESQLKI LIRPLYSNPP LNGARIASTI LTSPDLRKQW LQEVKGMADR IISMRTQLVS 370 380 390 400 410 420 NLKKEGSSHS WQHIADQIGM FCFTGLKPEQ VERLTKEFSI YMTKDGRISV AGVTSGNVGY 430 LAHAIHQVTK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence, comparative analysis, and population genetics of the domestic horse." Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T. , Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K. Science 326:865-867(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Thoroughbred Ensembl ENSECAP00000014550.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Thoroughbred Ensembl ENSECAP00000014550.

Cross-references

Sequence databases
RefSeq	XP_001495474.1. XM_001495424.3.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSECAT00000017874; ENSECAP00000014550; ENSECAG00000016504.
GeneID	100052607.
KEGG	ecb:100052607.
Phylogenomic databases
GeneTree	ENSGT00390000014081.
KO	K14455.
OMA	DFTGAIE.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
InterPro	IPR004839. Aminotransferase_I/II. IPR000796. Asp_trans. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11879. PTHR11879. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00799. TRANSAMINASE.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F6YXZ8_HORSE

Accession

Primary (citable) accession number: F6YXZ8

Entry history

Integrated into UniProtKB/TrEMBL:	July 27, 2011
Last sequence update:	July 27, 2011
Last modified:	March 6, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)