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Protein
Submitted name:

Thrombomodulin

Gene

THBD

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
ThrombomodulinImported
Gene namesi
Name:THBDImported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei512 – 535HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500334635424 – 571Sequence analysisAdd BLAST548

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000049854.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 158C-type lectinInterPro annotationAdd BLAST128
Domaini324 – 360EGF-likeInterPro annotationAdd BLAST37
Domaini364 – 404EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IF0T. Eukaryota.
ENOG410Y5JS. LUCA.
GeneTreeiENSGT00810000125382.
InParanoidiF6YV55.
KOiK03907.
OMAiLCGPLCV.
OrthoDBiEOG091G06M1.
TreeFamiTF330714.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link_sf.
IPR016316. CD141.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_cys_sf.
IPR015149. Tme5_EGF-like.
PANTHERiPTHR24036:SF5. PTHR24036:SF5. 1 hit.
PfamiView protein in Pfam
PF07645. EGF_CA. 2 hits.
PF00059. Lectin_C. 1 hit.
PF09064. Tme5_EGF_like. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 4 hits.
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.

Sequencei

Sequence statusi: Complete.

F6YV55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGAILLGVL ALAGLGLPAP AEPQPGGSQC VEHDCFALYP GPTTFLAASQ
60 70 80 90 100
ICVRLQGHLM TVRSSVAADV ISLLLSGDGE VGPRLWIGLQ LPPGCGDPNS
110 120 130 140 150
LGPLRGFQWV TGDNHTSYSR WAELYLNGAP LCGPLCVSVS AAGAPVPGEP
160 170 180 190 200
VWEEQPCDVK ADGFLCEFHF PATCRPLVVE PGAAAAAVRI TYGTPFAARG
210 220 230 240 250
ADFQALPVGS SASVAPLGLE LECAAPPGEV QGHWTRDAPG AWDCSVENGG
260 270 280 290 300
CEHACNASAG APRCLCPVGA ALQADGRSCT APAKQSCEDL CEHFCVRNPD
310 320 330 340 350
KPGSYSCMCE TGYQLADDLH RCVDVDDCML ESNLCPQRCV NTQGGFECHC
360 370 380 390 400
YPGYDLVDGE CVEPVDPCFG TNCEYQCQPL GQTSYRCICA EGFAPVPQQP
410 420 430 440 450
HRCQMFCNQT ACPADCDPNT KSNCECPEGY ILDEGFMCTD IDECENGGFC
460 470 480 490 500
SGECRNLLGT YECICGTDSA LTVQIGTDCD TDKVDGGDGG SGEPPVSPTP
510 520 530 540 550
GSTSNPPAAG RVHSGVLIGI SIASLSLVVA LLALLRHQRK KQGATRAKME
560 570
YKCAAPSKEV VLQHVRTEQT P
Length:571
Mass (Da):59,906
Last modified:July 27, 2011 - v1
Checksum:i9168102EDDAB3C41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFV01050592 Genomic DNA. No translation available.
RefSeqiXP_003732869.2. XM_003732821.3.

Genome annotation databases

EnsembliENSCJAT00000011231; ENSCJAP00000049854; ENSCJAG00000005795.
GeneIDi100390722.
KEGGicjc:100390722.

Similar proteinsi

Entry informationi

Entry nameiF6YV55_CALJA
AccessioniPrimary (citable) accession number: F6YV55
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 22, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported