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Protein
Submitted name:

Thrombomodulin

Gene

THBD

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
ThrombomodulinImported
Gene namesi
Name:THBDImported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei512 – 535HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500334635424 – 571Sequence analysisAdd BLAST548

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000049854

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 158C-type lectinInterPro annotationAdd BLAST128
Domaini324 – 360EGF-likeInterPro annotationAdd BLAST37
Domaini364 – 404EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IF0T Eukaryota
ENOG410Y5JS LUCA
GeneTreeiENSGT00810000125382
InParanoidiF6YV55
KOiK03907
OMAiLCGPLCV
OrthoDBiEOG091G06M1
TreeFamiTF330714

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016316 CD141
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR015149 Tme5_EGF-like
PANTHERiPTHR24036:SF5 PTHR24036:SF5, 1 hit
PfamiView protein in Pfam
PF07645 EGF_CA, 2 hits
PF00059 Lectin_C, 1 hit
PF09064 Tme5_EGF_like, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00181 EGF, 6 hits
SM00179 EGF_CA, 4 hits
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits

Sequencei

Sequence statusi: Complete.

F6YV55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGAILLGVL ALAGLGLPAP AEPQPGGSQC VEHDCFALYP GPTTFLAASQ
60 70 80 90 100
ICVRLQGHLM TVRSSVAADV ISLLLSGDGE VGPRLWIGLQ LPPGCGDPNS
110 120 130 140 150
LGPLRGFQWV TGDNHTSYSR WAELYLNGAP LCGPLCVSVS AAGAPVPGEP
160 170 180 190 200
VWEEQPCDVK ADGFLCEFHF PATCRPLVVE PGAAAAAVRI TYGTPFAARG
210 220 230 240 250
ADFQALPVGS SASVAPLGLE LECAAPPGEV QGHWTRDAPG AWDCSVENGG
260 270 280 290 300
CEHACNASAG APRCLCPVGA ALQADGRSCT APAKQSCEDL CEHFCVRNPD
310 320 330 340 350
KPGSYSCMCE TGYQLADDLH RCVDVDDCML ESNLCPQRCV NTQGGFECHC
360 370 380 390 400
YPGYDLVDGE CVEPVDPCFG TNCEYQCQPL GQTSYRCICA EGFAPVPQQP
410 420 430 440 450
HRCQMFCNQT ACPADCDPNT KSNCECPEGY ILDEGFMCTD IDECENGGFC
460 470 480 490 500
SGECRNLLGT YECICGTDSA LTVQIGTDCD TDKVDGGDGG SGEPPVSPTP
510 520 530 540 550
GSTSNPPAAG RVHSGVLIGI SIASLSLVVA LLALLRHQRK KQGATRAKME
560 570
YKCAAPSKEV VLQHVRTEQT P
Length:571
Mass (Da):59,906
Last modified:July 27, 2011 - v1
Checksum:i9168102EDDAB3C41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFV01050592 Genomic DNA No translation available.
RefSeqiXP_003732869.2, XM_003732821.3

Genome annotation databases

EnsembliENSCJAT00000011231; ENSCJAP00000049854; ENSCJAG00000005795
GeneIDi100390722
KEGGicjc:100390722

Similar proteinsi

Entry informationi

Entry nameiF6YV55_CALJA
AccessioniPrimary (citable) accession number: F6YV55
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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