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Protein
Submitted name:

Glutamate receptor 1

Gene

Gria1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate receptor 1Imported
Gene namesi
Name:Gria1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95808 Gria1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei466 – 488HelicalSequence analysisAdd BLAST23
Transmembranei549 – 571HelicalSequence analysisAdd BLAST23
Transmembranei739 – 761HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Proteomic databases

MaxQBiF6YNQ1
PeptideAtlasiF6YNQ1
PRIDEiF6YNQ1

Expressioni

Gene expression databases

BgeeiENSMUSG00000020524
ExpressionAtlasiF6YNQ1 baseline and differential
GenevisibleiF6YNQ1 MM

Structurei

3D structure databases

ProteinModelPortaliF6YNQ1
SMRiF6YNQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini339 – 714PBPeInterPro annotationAdd BLAST376
Domaini349 – 414Lig_chan-Glu_bdInterPro annotationAdd BLAST66

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1054 Eukaryota
ENOG410XPSH LUCA
GeneTreeiENSGT00910000143978

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequencei

Sequence statusi: Complete.

F6YNQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYRFCSQFS KGVYAIFGFY ERRTVNMLTS FCGALHVCFI TPSFPVDTSN
60 70 80 90 100
QFVLQLRPEL QEALISIIDH YKWQTFVYIY DADRGLSVLQ RVLDTAAEKN
110 120 130 140 150
WQVTAVNILT TTEEGYRMLF QDLEKKKERL VVVDCESERL NAILGQIVKL
160 170 180 190 200
EKNGIGYHYI LANLGFMDID LNKFKESGAN VTGFQLVNYT DTIPARIMQQ
210 220 230 240 250
WRTSDARDHT RVDWKRPKYT SALTYDGVKV MAEAFQSLRR QRIDISRRGN
260 270 280 290 300
AGDCLANPAV PWGQGIDIQR ALQQVRFEGL TGNVQFNEKG RRTNYTLHVI
310 320 330 340 350
EMKHDGIRKI GYWNEDDKFV PAATDAQAGG DNSSVQNRTY IVTTILEDPY
360 370 380 390 400
VMLKKNANQF EGNDRYEGYC VELAAEIAKH VGYSYRLEIV SDGKYGARDP
410 420 430 440 450
DTKAWNGMVG ELVYGRADVA VAPLTITLVR EEVIDFSKPF MSLGISIMIK
460 470 480 490 500
KPQKSKPGVF SFLDPLAYEI WMCIVFAYIG VSVVLFLVSR FSPYEWHSEE
510 520 530 540 550
FEEGRDQTTS DQSNEFGIFN SLWFSLGAFM QQGCDISPRS LSGRIVGGVW
560 570 580 590 600
WFFTLIIISS YTANLAAFLT VERMVSPIES AEDLAKQTEI AYGTLEAGST
610 620 630 640 650
KEFFRRSKIA VFEKMWTYMK SAEPSVFVRT TEEGMIRVRK SKGKYAYLLE
660 670 680 690 700
STMNEYIEQR KPCDTMKVGG NLDSKGYGIA TPKGSALRGP VNLAVLKLSE
710 720 730 740 750
QGVLDKLKSK WWYDKGECGS KDSGSKDKTS ALSLSNVAGV FYILIGGLGL
760 770 780 790 800
AMLVALIEFC YKSRSESKRM KGFCLIPQQS INEAIRTSTL PRNSGAGASG
810 820 830
GSGSGENGRV VSQDFPKSMQ SIPCMSHSSG MPLGATGL
Length:838
Mass (Da):93,968
Last modified:November 16, 2011 - v1
Checksum:iDF63B4852EA6879A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL663055 Genomic DNA No translation available.
AL672177 Genomic DNA No translation available.
AL954821 Genomic DNA No translation available.
BX248119 Genomic DNA No translation available.
RefSeqiNP_001239332.1, NM_001252403.1
XP_006532297.1, XM_006532234.3
UniGeneiMm.4920

Genome annotation databases

EnsembliENSMUST00000151045; ENSMUSP00000117746; ENSMUSG00000020524
GeneIDi14799

Similar proteinsi

Entry informationi

Entry nameiF6YNQ1_MOUSE
AccessioniPrimary (citable) accession number: F6YNQ1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health