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F6YNJ2

- F6YNJ2_HORSE

UniProt

F6YNJ2 - F6YNJ2_HORSE

Protein
Submitted name:

Uncharacterized protein

Gene

AXIN1

Organism
Equus caballus (Horse)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. signal transducer activity Source: Ensembl

    GO - Biological processi

    1. activation of protein kinase activity Source: Ensembl
    2. axial mesoderm formation Source: Ensembl
    3. canonical Wnt signaling pathway Source: Ensembl
    4. cellular protein complex assembly Source: Ensembl
    5. cytoplasmic microtubule organization Source: Ensembl
    6. dorsal/ventral axis specification Source: Ensembl
    7. genetic imprinting Source: Ensembl
    8. in utero embryonic development Source: Ensembl
    9. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    10. negative regulation of fat cell differentiation Source: Ensembl
    11. negative regulation of protein metabolic process Source: Ensembl
    12. negative regulation of transcription elongation from RNA polymerase II promoter Source: Ensembl
    13. nucleocytoplasmic transport Source: Ensembl
    14. positive regulation of JNK cascade Source: Ensembl
    15. positive regulation of JUN kinase activity Source: Ensembl
    16. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    17. positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
    18. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
    19. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
    20. positive regulation of transcription, DNA-templated Source: Ensembl
    21. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    22. positive regulation of ubiquitin-protein transferase activity Source: Ensembl
    23. post-anal tail morphogenesis Source: Ensembl
    24. protein catabolic process Source: Ensembl
    25. protein homooligomerization Source: Ensembl
    26. protein polyubiquitination Source: Ensembl
    27. regulation of catenin import into nucleus Source: Ensembl
    28. sensory perception of sound Source: Ensembl
    29. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:AXIN1Imported
    OrganismiEquus caballus (Horse)Imported
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Chromosome 13

    Subcellular locationi

    GO - Cellular componenti

    1. beta-catenin destruction complex Source: Ensembl
    2. cell cortex Source: Ensembl
    3. cytoplasmic membrane-bounded vesicle Source: Ensembl
    4. cytoplasmic microtubule Source: Ensembl
    5. lateral plasma membrane Source: Ensembl
    6. nucleus Source: Ensembl
    7. perinuclear region of cytoplasm Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiF6YNJ2.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 RGS domain.UniRule annotation
    Contains RGS domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000010011.
    OMAiIMQWIIE.
    OrthoDBiEOG79PJQ0.
    TreeFamiTF315454.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00021. DAX. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6YNJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVQEQGFPL DLGASFTEDA PRPPVPGEEG ELVSTDPRPV SHSFCSGKGP    50
    GIKGETSTAT PRRSDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIN 100
    LFRTFLKQED CADLLDFWFA CSGFRKLEPC DSNEEKRLKL AKAIYRKYIL 150
    DNNGIVSRQT KPATKSFIKD CIMKQLIDPA MFDQAQTEIQ STMEENTYPS 200
    FLKSDIYLEY TRTGSESPKL CSDQSSGSGT GKGIPGYLPT LNEDEEWKCD 250
    QDVDEDDGRD PGPPGRLTQK LLLETAAPRA SASRRYSEGR EFRYGSWREP 300
    VNPYYVNSGY ALAPATSAND SEQQSLSSDA DSLSLTDSSV DGVPPYRIRK 350
    QHRREMQESV QVNGRVPLPH IPRTYRMPKE IRVEPQKFAA ELIHRLEAIQ 400
    RTREAEEKLE ERLKRVRMEE EGEDGDVSCG PPGASHKLPS APAWHHFPPR 450
    YADMGCTGLR DAHEENPESI LDEHVQRVMR TPGCQSPGPG HRSPDSVHVP 500
    KVPGVLGGIA PGHGKHALKS GAKLDAAGLH LHRHSHHHGH HGLARPKEQA 550
    EAEAARRVQS SFSWALEQHG HTAKPRSHSE SVGAAHITSD GLTYSGKAGT 600
    TCKRNTKKAE SGKSMGAEAP GPSEDAEKNQ KIMQWIIEGE KEISRHRKAG 650
    HGSSGTKKQQ GHESSRPLSI ERPGAVHPWV SAQLRNSVQP SHLFIQDPTM 700
    PPNPAPNPLT QLEEARRRLE EEEKRASKLP SKQRYVQEVI QRGRSCARPA 750
    CTPVLSVVPA VSDLELSETE MKSQRKVGSS STQPCDSIVV AYYFCGEPIP 800
    YRTLVRGRAV TLGQFKELLT KKGNYRYYFK KVSDEFDCGV VFEEVREDEA 850
    VLPVFEEKII GKVEKVD 867
    Length:867
    Mass (Da):96,230
    Last modified:July 27, 2011 - v1
    Checksum:iAFAAAD3E4EAC49AC
    GO

    Genome annotation databases

    EnsembliENSECAT00000025514; ENSECAP00000021225; ENSECAG00000023674.

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F6YNJ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSECAT00000025514 ; ENSECAP00000021225 ; ENSECAG00000023674 .

    Phylogenomic databases

    GeneTreei ENSGT00390000010011.
    OMAi IMQWIIE.
    OrthoDBi EOG79PJQ0.
    TreeFami TF315454.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00021. DAX. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence, comparative analysis, and population genetics of the domestic horse."
      Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team
      Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.
      , Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.
      Science 326:865-867(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ThoroughbredImported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: ThoroughbredImported.

    Entry informationi

    Entry nameiF6YNJ2_HORSE
    AccessioniPrimary (citable) accession number: F6YNJ2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3