ID   F6YLP9_MOUSE            Unreviewed;       155 AA.
AC   F6YLP9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 {ECO:0000313|Ensembl:ENSMUSP00000114411.2};
DE   Flags: Fragment;
GN   Name=Plekha1 {ECO:0000313|Ensembl:ENSMUSP00000114411.2,
GN   ECO:0000313|MGI:MGI:2442213};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000114411.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000114411.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000114411.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000114411.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000114411.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   jPOST; F6YLP9; -.
DR   MaxQB; F6YLP9; -.
DR   PeptideAtlas; F6YLP9; -.
DR   ProteomicsDB; 367232; -.
DR   Antibodypedia; 1178; 220 antibodies from 27 providers.
DR   Ensembl; ENSMUST00000126355.2; ENSMUSP00000114411.2; ENSMUSG00000040268.18.
DR   AGR; MGI:2442213; -.
DR   MGI; MGI:2442213; Plekha1.
DR   VEuPathDB; HostDB:ENSMUSG00000040268; -.
DR   GeneTree; ENSGT00940000155157; -.
DR   HOGENOM; CLU_143896_0_0_1; -.
DR   ChiTaRS; Plekha1; mouse.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000040268; Expressed in retinal neural layer and 280 other cell types or tissues.
DR   ExpressionAtlas; F6YLP9; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR14336:SF4; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 1; 1.
DR   PANTHER; PTHR14336; TANDEM PH DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF00169; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Proteomics identification {ECO:0007829|EPD:F6YLP9,
KW   ECO:0007829|MaxQB:F6YLP9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          1..51
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          85..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          130..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..99
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000114411.2"
SQ   SEQUENCE   155 AA;  17181 MW;  9076B441E462F682 CRC64;
     XVHKVQECKQ SDIMMRDNLF EIVTTSRTFY VQADSPEEMH SWIKAVSGAI VAQRGPGRSS
     SSMRQARRLS NPCIQRYTSR AGECSTSIPA GLQNPNSLSV LPGPQPPPHI PQPLAATLWS
     QAVPWRSEEF TNLLPRSSQG TSRSRLSLQE SQLPK
//