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F6Y855

- F6Y855_MACMU

UniProt

F6Y855 - F6Y855_MACMU

Protein
Submitted name:

Uncharacterized protein

Gene

HK2

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hexokinase activity Source: Ensembl

    GO - Biological processi

    1. apoptotic mitochondrial changes Source: Ensembl
    2. glucose metabolic process Source: Ensembl
    3. glycolytic process Source: UniProtKB-KW
    4. regulation of glucose import Source: Ensembl

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:HK2Imported
    OrganismiMacaca mulatta (Rhesus macaque)Imported
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Chromosome 13

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial outer membrane Source: Ensembl

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the hexokinase family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000017159.
    KOiK00844.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 2 hits.
    PF03727. Hexokinase_2. 2 hits.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.
    PROSITEiPS00378. HEXOKINASES. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6Y855-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLSDETLLE ISKRFRKEME KGLGATTHPT AAVKMLPTFV RSTPDGTEHG    50
    EFLALDLGGT NFRVLWVKVT DNGLQKVEME NQIYAIPEDI MRGSGTQLFD 100
    HIAECLANFM DKLQIKDKKL PLGFTFSFPC HQTKLDESFL VSWTKGFKSS 150
    GVEGRDVVTL IRKAIQRRGD FDIDIVAVVN DTVGTMMTCG YDDHNCEIGL 200
    IVGTGSNACY MEEMRHIDMV EGDEGRMCIN MEWGAFGDDG SLNDIRTEFD 250
    QEIDMGSLNP GKQLFEKMIS GMYMGELVRL ILVKMAKEEL LFGGKLSPEL 300
    LNTGRFETKD ISDIEGEKDG IRKAREVLMR LGLDPTQEDC VATHRICQIV 350
    STRSASLCAA TLAAVLQRIK ENKGEERLRS TVGVDGSVYK KHPHFAKCLH 400
    KTVRRLVPDC DVRFLRSEDG SGKGAAMVTA VAYRLADQHR ARQKTLEPLQ 450
    LSHDQLLEVK RRMKVEMERG LSKETHAIAP VKMLPTYVCA TPDGTEKGDF 500
    LALDLGGTNF RVLLVRVRNG KWGGVEMHNK IYAIPQEVMH GTGDELFDHI 550
    VQCIADFLEY MGMKGVSLPL GFTFSFPCQQ NSLDESILLK WTKGFKASGC 600
    EGEDVVTLLK EAIHRREEFD LDVVAVVNDT VGTMMTCGFE DPHCEVGLIV 650
    GTGSNACYME EMRNVELVEG EEGRMCVNME WGAFGDNGCL DDFCTEFDVA 700
    VDELSLNPGK QRFEKMISGM YLGEIVRNIL IDFTKRGLLF RGRISERLKT 750
    RGIFETKFLS QIESDCLALL QVRAILQHLG LESTCDDSII VKEVCTVVAR 800
    RAAQLCGAGM AAVVDKIREN RGLDALKVTV GVDGTLYKLH PHFAKVMHET 850
    VKDLAPKCDV SFLQSEDGSG KGAALITAVA CRIREAGQR 889
    Length:889
    Mass (Da):98,899
    Last modified:July 27, 2011 - v1
    Checksum:iEF61A0AD35083F75
    GO

    Sequence databases

    RefSeqiXP_001111663.1. XM_001111663.2.
    UniGeneiMmu.13636.

    Genome annotation databases

    EnsembliENSMMUT00000043433; ENSMMUP00000036433; ENSMMUG00000011845.
    GeneIDi710479.
    KEGGimcc:710479.

    Cross-referencesi

    Sequence databases

    RefSeqi XP_001111663.1. XM_001111663.2.
    UniGenei Mmu.13636.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMMUT00000043433 ; ENSMMUP00000036433 ; ENSMMUG00000011845 .
    GeneIDi 710479.
    KEGGi mcc:710479.

    Organism-specific databases

    CTDi 3099.

    Phylogenomic databases

    GeneTreei ENSGT00390000017159.
    KOi K00844.

    Miscellaneous databases

    NextBioi 19979479.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 2 hits.
    PF03727. Hexokinase_2. 2 hits.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    PROSITEi PS00378. HEXOKINASES. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary and biomedical insights from the rhesus macaque genome."
      Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C., Makova K.D., Miller W., Milosavljevic A.
      , Palermo R.E., Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., Zwieg A.S.
      Science 316:222-234(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17573Imported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: 17573Imported.

    Entry informationi

    Entry nameiF6Y855_MACMU
    AccessioniPrimary (citable) accession number: F6Y855
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3