ID   F6XZA4_MOUSE            Unreviewed;       153 AA.
AC   F6XZA4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   RecName: Full=NF-kappa-B inhibitor-interacting Ras-like protein 2 {ECO:0000256|ARBA:ARBA00040455};
DE   AltName: Full=I-kappa-B-interacting Ras-like protein 2 {ECO:0000256|ARBA:ARBA00041822};
DE   Flags: Fragment;
GN   Name=Nkiras2 {ECO:0000313|Ensembl:ENSMUSP00000114456.2,
GN   ECO:0000313|MGI:MGI:1919216};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000114456.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000114456.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000114456.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000114456.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000114456.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC       KappaB-Ras subfamily. {ECO:0000256|ARBA:ARBA00008094}.
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DR   AlphaFoldDB; F6XZA4; -.
DR   SMR; F6XZA4; -.
DR   MaxQB; F6XZA4; -.
DR   PeptideAtlas; F6XZA4; -.
DR   ProteomicsDB; 316003; -.
DR   Antibodypedia; 79897; 239 antibodies from 31 providers.
DR   Ensembl; ENSMUST00000142993.2; ENSMUSP00000114456.2; ENSMUSG00000017837.13.
DR   AGR; MGI:1919216; -.
DR   MGI; MGI:1919216; Nkiras2.
DR   VEuPathDB; HostDB:ENSMUSG00000017837; -.
DR   GeneTree; ENSGT00940000157943; -.
DR   HOGENOM; CLU_041217_17_2_1; -.
DR   OMA; IMDRANN; -.
DR   ChiTaRS; Nkiras2; mouse.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000017837; Expressed in spermatocyte and 230 other cell types or tissues.
DR   ExpressionAtlas; F6XZA4; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR042227; KBRS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR46152; NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN; 1.
DR   PANTHER; PTHR46152:SF2; NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN 2; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00173; RAS; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   1: Evidence at protein level;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Proteomics identification {ECO:0007829|EPD:F6XZA4,
KW   ECO:0007829|MaxQB:F6XZA4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   NON_TER         153
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000114456.2"
SQ   SEQUENCE   153 AA;  17316 MW;  2030D17CA50AA3E3 CRC64;
     MGKSCKVVVC GQASVGKTSI LEQLLYGNHV VGSEMIETQE DIYVGSIETD RGVREQVRFY
     DTRGLRDGAE LPKHCFSCTD GYVLVYSTDS RESFQRVELL KKEIDKSKDK KEVTIVVLGN
     KCDLQEQRRV DPDVAQHWAK SEKVKLWEVS VAD
//