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Protein
Submitted name:

Nuclear receptor subfamily 3 group C member 2

Gene

NR3C2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi597 – 672Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CFA-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).
R-CFA-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor subfamily 3 group C member 2Imported
Gene namesi
Name:NR3C2Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiF6XWQ1.

Expressioni

Gene expression databases

BgeeiENSCAFG00000007813.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000011569.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini597 – 672Nuclear receptorInterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.SAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118887.
InParanoidiF6XWQ1.
OMAiSKICLVC.
OrthoDBiEOG091G0166.
TreeFamiTF106510.

Family and domain databases

Gene3Di3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F6XWQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METKGYHSLP EGLDMERRWG QVSQAVEHSS LGPTERTDEN NYMEIVNVSC
60 70 80 90 100
VSGAIPNNST QGSSKEKHEL LPCLQQDNNR SGILTSDIKT ELESKELSAT
110 120 130 140 150
VAESMGLYMD SVRDADYTYD QQNQQGSMSP AKIYQNVEQL VKFYKENGHH
160 170 180 190 200
PSTLGGVNRP LRSFMSDSGS SVNGGVMRAI VKSPIMCHEK SPSVCSPLNM
210 220 230 240 250
TSSVCSPAGI SSVSSTSASF GSFTVHSPIT QGTPLTCSPN VENRGSRSHS
260 270 280 290 300
PAHVGSPLSS PLSSMKSPIS SPPSHCSVKS PVSSPNNVTL RSSVSSPANI
310 320 330 340 350
NNSRCSVSSP SNTNNRSTLS SPTASTVGSI CSPVNNAFSY TASGTPAGSS
360 370 380 390 400
VARDVVPSPD TQEKGAQEVP FPKSEEVENA ISNGVTGQLN IVQYIKPEPD
410 420 430 440 450
GAFSSSCLGG NNKINSDSPF SVPIKQESTK HSCSGTSFKG NPTVNPFPFM
460 470 480 490 500
DGSYFSFMDD KDYYSLSGIL GPPVPGFDGN CEGSGFPMGI KQEPDDGSYY
510 520 530 540 550
PEASIPSSAI VGVNSGGQSF HYRIGAQGTI SLSRSARDQS FQHLSSFPPV
560 570 580 590 600
NTLVESWKSH GDLSSRRNDG YPVLEYIPEN VTSSTLRSVS TGSSRPSKIC
610 620 630 640 650
LVCGDEASGC HYGVVTCGSC KVFFKRAVEG QHNYLCAGRN DCIIDKIRRK
660 670 680 690 700
NCPACRLQKC LQAGMNLGAR KSKKLGKLKG AHEEPPPAPP QSPEEGAPYL
710 720 730 740 750
APAQEPPVPA ALVPQLAAVS RALAPSPVTI LESIEPEVVY AGYDSSKPDT
760 770 780 790 800
AENLLSTLNR LAGKQMIQVV KWAKVLPGFR NLPLEDQITL IQYSWMCLSS
810 820 830 840 850
FALSWRSYKH TNSQFLYFAP DLVFNEEKMH QSAMYELCQG MHQISLQFVR
860 870 880 890 900
LQLTFEEYTI MKVLLLLSTI PKDGLKSQAA FEEMRTNYIK ELRKMVTKCP
910 920 930 940 950
SNSGQSWQRF YQLTKLLDSM HDLVSDLLEF CFYTFRESQA LKVEFPAMLV
960 970
EIISDQLPKV ESGNAKPLYF HRK
Length:973
Mass (Da):105,701
Last modified:October 31, 2012 - v1
Checksum:i168B1E57D0DC7B4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03010024 Genomic DNA. No translation available.
RefSeqiXP_013974915.1. XM_014119440.1.
XP_013974916.1. XM_014119441.1.
UniGeneiCfa.32999.

Genome annotation databases

EnsembliENSCAFT00000012489; ENSCAFP00000011569; ENSCAFG00000007813.
GeneIDi475461.

Similar proteinsi

Entry informationi

Entry nameiF6XWQ1_CANLF
AccessioniPrimary (citable) accession number: F6XWQ1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: September 27, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported