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Protein
Submitted name:

Inhibitor of nuclear factor kappa-B kinase subunit beta

Gene

Ikbkb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1169091. Activation of NF-kappaB in B cells.
R-MMU-168638. NOD1/2 Signaling Pathway.
R-MMU-1810476. RIP-mediated NFkB activation via ZBP1.
R-MMU-202424. Downstream TCR signaling.
R-MMU-209543. p75NTR recruits signalling complexes.
R-MMU-209560. NF-kB is activated and signals survival.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-MMU-446652. Interleukin-1 signaling.
R-MMU-5357905. Regulation of TNFR1 signaling.
R-MMU-5357956. TNFR1-induced NFkappaB signaling pathway.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-MMU-933542. TRAF6 mediated NF-kB activation.
R-MMU-937039. IRAK1 recruits IKK complex.
R-MMU-975144. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.

Names & Taxonomyi

Protein namesi
Submitted name:
Inhibitor of nuclear factor kappa-B kinase subunit betaImported
Gene namesi
Name:IkbkbImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1338071. Ikbkb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiF6XPL0.
PaxDbiF6XPL0.

Expressioni

Gene expression databases

BgeeiF6XPL0.
ExpressionAtlasiF6XPL0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033939.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 2929IKKbetaNEMObindInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG4250. Eukaryota.
ENOG410XRMU. LUCA.
GeneTreeiENSGT00820000127009.

Family and domain databases

InterProiIPR022007. IKKbetaNEMObind.
[Graphical view]
PfamiPF12179. IKKbetaNEMObind. 1 hit.
[Graphical view]
SMARTiSM01239. IKKbetaNEMObind. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

F6XPL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
VAEAHALCSR LESALQDTVK EQDRSFTAQS SRNFS
Length:35
Mass (Da):3,883
Last modified:July 27, 2011 - v1
Checksum:i533D809C238A5C02
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121835 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000132279; ENSMUSP00000120049; ENSMUSG00000031537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121835 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033939.

Proteomic databases

EPDiF6XPL0.
PaxDbiF6XPL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000132279; ENSMUSP00000120049; ENSMUSG00000031537.

Organism-specific databases

MGIiMGI:1338071. Ikbkb.

Phylogenomic databases

eggNOGiKOG4250. Eukaryota.
ENOG410XRMU. LUCA.
GeneTreeiENSGT00820000127009.

Enzyme and pathway databases

ReactomeiR-MMU-1169091. Activation of NF-kappaB in B cells.
R-MMU-168638. NOD1/2 Signaling Pathway.
R-MMU-1810476. RIP-mediated NFkB activation via ZBP1.
R-MMU-202424. Downstream TCR signaling.
R-MMU-209543. p75NTR recruits signalling complexes.
R-MMU-209560. NF-kB is activated and signals survival.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-MMU-446652. Interleukin-1 signaling.
R-MMU-5357905. Regulation of TNFR1 signaling.
R-MMU-5357956. TNFR1-induced NFkappaB signaling pathway.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-MMU-933542. TRAF6 mediated NF-kB activation.
R-MMU-937039. IRAK1 recruits IKK complex.
R-MMU-975144. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiF6XPL0.
ExpressionAtlasiF6XPL0. baseline and differential.

Family and domain databases

InterProiIPR022007. IKKbetaNEMObind.
[Graphical view]
PfamiPF12179. IKKbetaNEMObind. 1 hit.
[Graphical view]
SMARTiSM01239. IKKbetaNEMObind. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF6XPL0_MOUSE
AccessioniPrimary (citable) accession number: F6XPL0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.