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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene
N/A
Organism
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-methyl-5'-thioadenosine phosphorylase, S-methyl-5'-thioadenosine phosphorylase (LOC100177521)
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route), the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei18PhosphateUniRule annotation1
Sitei178Important for substrate specificityUniRule annotation1
Binding sitei196Substrate; via amide nitrogenUniRule annotation1
Binding sitei197PhosphateUniRule annotation1
Sitei233Important for substrate specificityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

UniPathwayiUPA00904; UER00873

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Short name:
MTAPaseUniRule annotation
OrganismiCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Taxonomic identifieri7719 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaEnterogonaPhlebobranchiaCionidaeCiona
Proteomesi
  • UP000008144 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004151161 – 280S-methyl-5'-thioadenosine phosphorylaseAdd BLAST280

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi7719.ENSCINP00000005182

Structurei

3D structure databases

SMRiF6X2V8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 61Phosphate bindingUniRule annotation2
Regioni93 – 94Phosphate bindingUniRule annotation2
Regioni220 – 222Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3985 Eukaryota
COG0005 LUCA
KOiK00772

Family and domain databases

HAMAPiMF_01963 MTAP, 1 hit
InterProiView protein in InterPro
IPR010044 MTAP
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR018099 Purine_phosphorylase-2_CS
PANTHERiPTHR42679 PTHR42679, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01694 MTAP, 1 hit
PROSITEiView protein in PROSITE
PS01240 PNP_MTAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

F6X2V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMESGDRQNN KIGIIGGSGL ESIELFTVKD KVNCNTPYGK PSSSLINGTL
60 70 80 90 100
NGIECVLLSR HGDSHDIMPT DVNYRANLYA LKEAGCSIIL ATTACGSLQE
110 120 130 140 150
ELKPTDFVVI DQFIDRTTKR HSTFYDGQNV QMKGVCHIPM RNPFCEKLQN
160 170 180 190 200
VLLSACNVNN VSCHSKGTMV TIEGPRFSTY AESNLFRKWG GSLINMTTVP
210 220 230 240 250
EVVLANELGM LYAALAMVTD YDCWKEDHAS VNVENVMKTM KVNRGNALKV
260 270 280
LVSAVEIISK QNLQPDIQLA EKNAKNSVML
Length:280
Mass (Da):30,829
Last modified:July 27, 2011 - v1
Checksum:iFDA5FC0E8A8A4B58
GO

Sequence databases

RefSeqiXP_002131665.1, XM_002131629.4
XP_018667802.1, XM_018812257.1
UniGeneiCin.28055

Genome annotation databases

GeneIDi100177521
KEGGicin:100177521

Similar proteinsi

Entry informationi

Entry nameiMTAP_CIOIN
AccessioniPrimary (citable) accession number: F6X2V8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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