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Protein

Fibroblast growth factor

Gene

fgf4

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-XTR-109704. PI3K Cascade.
R-XTR-1257604. PIP3 activates AKT signaling.
R-XTR-190322. FGFR4 ligand binding and activation.
R-XTR-190372. FGFR3c ligand binding and activation.
R-XTR-190373. FGFR1c ligand binding and activation.
R-XTR-190375. FGFR2c ligand binding and activation.
R-XTR-5654219. Phospholipase C-mediated cascade: FGFR1.
R-XTR-5654221. Phospholipase C-mediated cascade, FGFR2.
R-XTR-5654227. Phospholipase C-mediated cascade, FGFR3.
R-XTR-5654228. Phospholipase C-mediated cascade, FGFR4.
R-XTR-5654687. Downstream signaling of activated FGFR1.
R-XTR-5654688. SHC-mediated cascade:FGFR1.
R-XTR-5654689. PI-3K cascade:FGFR1.
R-XTR-5654693. FRS-mediated FGFR1 signaling.
R-XTR-5654695. PI-3K cascade:FGFR2.
R-XTR-5654699. SHC-mediated cascade:FGFR2.
R-XTR-5654700. FRS-mediated FGFR2 signaling.
R-XTR-5654704. SHC-mediated cascade:FGFR3.
R-XTR-5654706. FRS-mediated FGFR3 signaling.
R-XTR-5654710. PI-3K cascade:FGFR3.
R-XTR-5654712. FRS-mediated FGFR4 signaling.
R-XTR-5654719. SHC-mediated cascade:FGFR4.
R-XTR-5654720. PI-3K cascade:FGFR4.
R-XTR-5654726. Negative regulation of FGFR1 signaling.
R-XTR-5654727. Negative regulation of FGFR2 signaling.
R-XTR-5654732. Negative regulation of FGFR3 signaling.
R-XTR-5654733. Negative regulation of FGFR4 signaling.
R-XTR-5658623. FGFRL1 modulation of FGFR1 signaling.
R-XTR-5673001. RAF/MAP kinase cascade.
R-XTR-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factorUniRule annotation
Short name:
FGFUniRule annotation
Gene namesi
Name:fgf4Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-480496. fgf4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 36HelicalSequence analysisAdd BLAST31

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiF6WY95.

Expressioni

Gene expression databases

BgeeiENSXETG00000001992.
ExpressionAtlasiF6WY95. baseline.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000004269.

Family & Domainsi

Sequence similaritiesi

Belongs to the heparin-binding growth factors family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
InParanoidiF6WY95.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiView protein in InterPro
IPR028239. FGF4.
IPR002209. Fibroblast_GF_fam.
IPR008996. IL1/FGF.
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF31. PTHR11486:SF31. 1 hit.
PfamiView protein in Pfam
PF00167. FGF. 1 hit.
PRINTSiPR00263. HBGFFGF.
SMARTiView protein in SMART
SM00442. FGF. 1 hit.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00247. HBGF_FGF. 1 hit.

Sequencei

Sequence statusi: Fragment.

F6WY95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KTFGQFSFLV SLCCLRMTVP SALVPILLLG MAAVVVQGLP LSSSLRNDTL
60 70 80 90 100
ERRWETLFSR SMARIPGEKR DMSRESDYLL GIKRLRRLYC NVGIGFHIQV
110 120 130 140 150
LPDGRINGMH NENRYSLLEI SPVEVGVVSL YGVKSAMFVA MNAKGKLYGS
160 170 180 190 200
RHFNDECKFK ETLLPNNYNA YESRKYPGMY IALSKNGRTK KGNRVSPTMT

LTHFLPRI
Length:208
Mass (Da):23,558
Last modified:July 27, 2011 - v1
Checksum:i9D3BE7CBD380A5C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01030090 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSXETT00000004269; ENSXETP00000004269; ENSXETG00000001992.

Similar proteinsi

Entry informationi

Entry nameiF6WY95_XENTR
AccessioniPrimary (citable) accession number: F6WY95
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 25, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported