Arhgef6

Functionⁱ

GO - Molecular functionⁱ

Rho guanyl-nucleotide exchange factor activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

intracellular signal transduction Source: InterPro
regulation of Rho protein signal transduction Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factorSAAS annotation

Molecular function

Guanine-nucleotide releasing factorSAAS annotation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-193648. NRAGE signals death through JNK. R-MMU-194840. Rho GTPase cycle. R-MMU-416482. G alpha (12/13) signalling events. R-MMU-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.

Reactomeⁱ

R-MMU-193648. NRAGE signals death through JNK.
R-MMU-194840. Rho GTPase cycle.
R-MMU-416482. G alpha (12/13) signalling events.
R-MMU-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Rho guanine nucleotide exchange factor 6Imported
Gene namesⁱ	Name:Arhgef6Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:1920591. Arhgef6.

Subcellular locationⁱ

GO - Cellular componentⁱ

intracellular Source: GOC

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F6WMJ3.
PaxDbⁱ	F6WMJ3.
PeptideAtlas More...PeptideAtlasⁱ	F6WMJ3.
PRIDEⁱ	F6WMJ3.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000031133.
ExpressionAtlasⁱ	F6WMJ3. baseline and differential.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F6WMJ3.
SMRⁱ	F6WMJ3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	25 – 134	Actin-bindingInterPro annotationAdd BLAST	110
Domainⁱ	183 – 242	SH3InterPro annotationAdd BLAST	60
Domainⁱ	264 – 444	DH (DBL-homology)InterPro annotationAdd BLAST	181
Domainⁱ	466 – 571	PHInterPro annotationAdd BLAST	106

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	737 – 778	Sequence analysisAdd BLAST		42

Keywords - Domainⁱ

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG2070. Eukaryota. ENOG410XNNP. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118925.
HOVERGENⁱ	HBG050569.
KEGG Orthology (KO) More...KOⁱ	K05729.
OMAⁱ	FQEWLEQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04XA.
TreeFamⁱ	TF316105.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00014. CH. 1 hit.
Gene3Dⁱ	1.10.418.10. 1 hit. 2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR001715. CH-domain. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR032409. GEF_CC. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR001452. SH3_domain. IPR003096. SM22_calponin.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16523. betaPIX_CC. 1 hit. PF00307. CH. 1 hit. PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. PF14604. SH3_9. 1 hit.
PRINTSⁱ	PR00452. SH3DOMAIN. PR00888. SM22CALPONIN.
SMARTⁱ	View protein in SMART SM00033. CH. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. SM00326. SH3. 1 hit.
SUPFAMⁱ	SSF47576. SSF47576. 1 hit. SSF48065. SSF48065. 1 hit. SSF50044. SSF50044. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50021. CH. 1 hit. PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50002. SH3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

F6WMJ3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQSRMWLSLH SCPESCSERP RASVMNPEER LVTWLISLGV LESPKKTVCD 
        60         70         80         90        100
PEEFLKSSLK NGVVLCKLIN RLLPGSVEKY CLEPQTEADC IDNINDFLKG 
       110        120        130        140        150
CATLQVEVFE PDDLYSGANF SKVLNTLLAV NKATEDQLSE RPCGRSSSLS 
       160        170        180        190        200
AATSSQTNPQ VAVPSTAPEQ HSEEKAEMTE NGSHQLIVKA RFNFKQTNED 
       210        220        230        240        250
ELSVCKGDII YVTRVEEGGW WEGTLNGRTG WFPSNYVREI KPSERPLSPK 
       260        270        280        290        300
AIKGFDTAPL TKNYYTVVLQ NILDTEKEYA KELQSLLVTY LRPLQSNNNL 
       310        320        330        340        350
STVEFTCLLG NFEEVCTFQQ TLCQALEECS KFPENQHKVG GCLLNLMPHF 
       360        370        380        390        400
KSMYLAYCAN HPSAVNVLTQ HSDDLERFME NQGASSPGIL ILTTSLSKPF 
       410        420        430        440        450
MRLEKYVTLL QELERHMEDT HPDHQDILKA IIAFKTLMGQ CQDLRKRKQL 
       460        470        480        490        500
ELQILSEPIQ AWEGDDIKTL GNVIFMSQVV MQHGACEEKE ERYFLLFSSV 
       510        520        530        540        550
LIMLSASPRM SGFMYQGKIP IAGMVVNRLD EIEGSDCMFE ITGSTVERIV 
       560        570        580        590        600
VHCNNNQDFQ EWMEQLNRLT KGPTSCGSLS KTSSSSCSTH SSFSSTGQPR 
       610        620        630        640        650
GPLEPPQIIK PWSLSCLRPA PPLRPSAALG YKERMSYILK ESSKSPKTMK 
       660        670        680        690        700
KFLHKRKTER KASEEEYVIR KSTAALEEDA QILKVIEAYC TSASFQQGTR 
       710        720        730        740        750
KDSVPQVLLP EEEKLIIEET RSNGQTIIEE KSLVDTVYAL KDEVKELKQE 
       760        770        780        790 
NKKMKQCLEE ELKSRKDLEK LVRKLLKQTD ECIRSESSSK TSILQ

Length:795

Mass (Da):89,812

Last modified:April 18, 2012 - v1

Checksum:ⁱC6FF930EF2558681

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL672106 Genomic DNA. No translation available. AL672128 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_690014.2. NM_152801.2.
UniGeneⁱ	Mm.261443.

Genome annotation databases

Ensemblⁱ	ENSMUST00000033468; ENSMUSP00000033468; ENSMUSG00000031133.
GeneIDⁱ	73341.
KEGGⁱ	mmu:73341.
UCSC genome browser More...UCSCⁱ	uc009thd.2. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL672106 Genomic DNA. No translation available. AL672128 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_690014.2. NM_152801.2.
UniGeneⁱ	Mm.261443.

3D structure databases

ProteinModelPortalⁱ	F6WMJ3.
SMRⁱ	F6WMJ3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F6WMJ3.
PaxDbⁱ	F6WMJ3.
PeptideAtlas More...PeptideAtlasⁱ	F6WMJ3.
PRIDEⁱ	F6WMJ3.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000033468; ENSMUSP00000033468; ENSMUSG00000031133.
GeneIDⁱ	73341.
KEGGⁱ	mmu:73341.
UCSC genome browser More...UCSCⁱ	uc009thd.2. mouse.

Organism-specific databases

CTDⁱ	9459.
MGIⁱ	MGI:1920591. Arhgef6.

Phylogenomic databases

eggNOGⁱ	KOG2070. Eukaryota. ENOG410XNNP. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118925.
HOVERGENⁱ	HBG050569.
KEGG Orthology (KO) More...KOⁱ	K05729.
OMAⁱ	FQEWLEQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04XA.
TreeFamⁱ	TF316105.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-193648. NRAGE signals death through JNK. R-MMU-194840. Rho GTPase cycle. R-MMU-416482. G alpha (12/13) signalling events. R-MMU-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.

Reactomeⁱ

R-MMU-193648. NRAGE signals death through JNK.
R-MMU-194840. Rho GTPase cycle.
R-MMU-416482. G alpha (12/13) signalling events.
R-MMU-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031133.
ExpressionAtlasⁱ	F6WMJ3. baseline and differential.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00014. CH. 1 hit.
Gene3Dⁱ	1.10.418.10. 1 hit. 2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR001715. CH-domain. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR032409. GEF_CC. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR001452. SH3_domain. IPR003096. SM22_calponin.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16523. betaPIX_CC. 1 hit. PF00307. CH. 1 hit. PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. PF14604. SH3_9. 1 hit.
PRINTSⁱ	PR00452. SH3DOMAIN. PR00888. SM22CALPONIN.
SMARTⁱ	View protein in SMART SM00033. CH. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. SM00326. SH3. 1 hit.
SUPFAMⁱ	SSF47576. SSF47576. 1 hit. SSF48065. SSF48065. 1 hit. SSF50044. SSF50044. 1 hit. SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50021. CH. 1 hit. PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50002. SH3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F6WMJ3_MOUSE
Accessionⁱ	F6WMJ3Primary (citable) accession number: F6WMJ3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 18, 2012
	Last sequence update:	April 18, 2012
	Last modified:	July 5, 2017
	This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F6WMJ3 (F6WMJ3_MOUSE)

Your basket is currently empty.

Rho guanine nucleotide exchange factor 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ