FUS

Functionⁱ

GO - Molecular functionⁱ

identical protein binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
RNA binding Source: UniProtKB-UniRule
transcription coactivator activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-bindingPROSITE-ProRule annotation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: FUS RNA binding proteinImported
Gene namesⁱ	Name:FUSImported
Organismⁱ	Monodelphis domestica (Gray short-tailed opossum)Imported
Taxonomic identifierⁱ	13616 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Metatheria › Didelphimorphia › Didelphidae › Didelphinae › Monodelphis
Proteomesⁱ	UP000002280 Componentⁱ: Chromosome 6

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMODG00000001889

Bgeeⁱ

ENSMODG00000001889

Interactionⁱ

GO - Molecular functionⁱ

identical protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	13616.ENSMODP00000002300

STRINGⁱ

13616.ENSMODP00000002300

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F6WGL5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	286 – 372	RRMInterPro annotationAdd BLAST		87
Domainⁱ	423 – 454	RanBP2-typeInterPro annotationAdd BLAST		32

Keywords - Domainⁱ

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	ENOG410IP58 Eukaryota ENOG4111GEG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063105
InParanoidⁱ	F6WGL5
KEGG Orthology (KO) More...KOⁱ	K13098
OMAⁱ	DSYNKGP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0U8W
TreeFamⁱ	TF322599

Family and domain databases

Gene3Dⁱ	3.30.70.3301 hit
InterProⁱ	View protein in InterPro IPR034459 FUS IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR034870 TET_fam IPR001876 Znf_RanBP2 IPR036443 Znf_RanBP2_sf
PANTHERⁱ	PTHR23238 PTHR23238, 1 hit PTHR23238:SF5 PTHR23238:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit PF00641 zf-RanBP, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit SM00547 ZnF_RBZ, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit SSF90209 SSF90209, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit PS01358 ZF_RANBP2_1, 1 hit PS50199 ZF_RANBP2_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

F6WGL5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASNEYTQPA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YGQSADTSGY 
        60         70         80         90        100
GQSSYGSSYG QTQNTGYGTQ SAPQGYGSTS GYGSSQSSQP SYGQQSSYPG 
       110        120        130        140        150
YSQQPAPSST SGSYGSSSQS SSYGQPQSGG YGQQSGYGGQ QQSSYGQQQS 
       160        170        180        190        200
SYNPPQGYGQ QNQYNSSSGG GGGGGGGSYG QDQSSMSGGS GGGYGNQDQS 
       210        220        230        240        250
GGGSSSSYGG GQQDRGGRGR GGGGGSSSGG GGYNRNSGGY EPRGRGGGRG 
       260        270        280        290        300
GRGGMGGSDR GGFNKFGGPR DQGSRHDSEQ DNSDNNTIFV QGLGENVTIE 
       310        320        330        340        350
SVADYFKQIG IIKTNKKTGQ PMINLYTDRE TGKLKGEATV SFDDPPSAKA 
       360        370        380        390        400
AIDWFDGKEF SGNPIKVSFA TRRADFNRGG GNGRGGRGRG GPMGRGGFGG 
       410        420        430        440        450
GGSGGGSRGG FPSGGGGGGG QQRAGDWKCP NPTCENMNFS WRNECNQCKA 
       460        470        480        490        500
PKPDGPGGGP GGSHMGGNFG DDRRGGRGGY DRGGYRGRGG DRGGFRGGRG 
       510        520 
GGDRGGFGPG KMDSRGEHRQ DRRERPY

Length:527

Mass (Da):53,538

Last modified:January 9, 2013 - v2

Checksum:ⁱBD9DEEBA7D964725

GO

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_001364792.1, XM_001364755.3

RefSeqⁱ

XP_001364792.1, XM_001364755.3

Genome annotation databases

Ensemblⁱ	ENSMODT00000002348; ENSMODP00000002300; ENSMODG00000001889
GeneIDⁱ	100013799
KEGGⁱ	mdo:100013799

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F6WGL5	P35637 Q6IBQ5 UPI00064349F6 UPI0005F545F0 A0A2K6UY94 UPI00080A21AC UPI0005F56B3C UPI000533CD74 UPI0004434FB4 UPI00080A0552 +58	Homo sapiens (Human) Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur) Colobus angolensis palliatus (Peters' Angolan colobus) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Cebus capucinus imitator Monodelphis domestica (Gray short-tailed opossum) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Callithrix jacchus (White-tufted-ear marmoset) Pan troglodytes (Chimpanzee) Aotus nancymaae (Ma's night monkey) And more	526	UniRef90_P35637	Cluster: RNA-binding protein FUS	69

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
F6WGL5	P35637 Q6IBQ5 UPI00064349F6 UPI0005F545F0 A0A2K6UY94 UPI0005F56B3C UPI00080A21AC UPI000533CD74 A0A2J8TL12 UPI00080A0552 +69	Homo sapiens (Human) Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur) Colobus angolensis palliatus (Peters' Angolan colobus) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Cebus capucinus imitator Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Monodelphis domestica (Gray short-tailed opossum) Callithrix jacchus (White-tufted-ear marmoset) Pan troglodytes (Chimpanzee) Ochotona princeps (Southern American pika) And more	526	UniRef50_P35637	Cluster: RNA-binding protein FUS	80

Cross-referencesⁱ

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_001364792.1, XM_001364755.3

RefSeqⁱ

XP_001364792.1, XM_001364755.3

3D structure databases

ProteinModelPortalⁱ	F6WGL5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	13616.ENSMODP00000002300

STRINGⁱ

13616.ENSMODP00000002300

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMODT00000002348; ENSMODP00000002300; ENSMODG00000001889
GeneIDⁱ	100013799
KEGGⁱ	mdo:100013799

Organism-specific databases

CTDⁱ	2521

CTDⁱ

2521

Phylogenomic databases

eggNOGⁱ	ENOG410IP58 Eukaryota ENOG4111GEG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063105
InParanoidⁱ	F6WGL5
KEGG Orthology (KO) More...KOⁱ	K13098
OMAⁱ	DSYNKGP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0U8W
TreeFamⁱ	TF322599

Gene expression databases

Bgeeⁱ	ENSMODG00000001889

Bgeeⁱ

ENSMODG00000001889

Family and domain databases

Gene3Dⁱ	3.30.70.3301 hit
InterProⁱ	View protein in InterPro IPR034459 FUS IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR034870 TET_fam IPR001876 Znf_RanBP2 IPR036443 Znf_RanBP2_sf
PANTHERⁱ	PTHR23238 PTHR23238, 1 hit PTHR23238:SF5 PTHR23238:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit PF00641 zf-RanBP, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit SM00547 ZnF_RBZ, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit SSF90209 SSF90209, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit PS01358 ZF_RANBP2_1, 1 hit PS50199 ZF_RANBP2_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F6WGL5_MONDO
Accessionⁱ	F6WGL5Primary (citable) accession number: F6WGL5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 27, 2011
	Last sequence update:	January 9, 2013
	Last modified:	March 28, 2018
	This is version 47 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F6WGL5 (F6WGL5_MONDO)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

FUS RNA binding protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ