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F6WCX7

- F6WCX7_HUMAN

UniProt

F6WCX7 - F6WCX7_HUMAN

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Protein
Submitted name: Dual-specificity mitogen-activated protein kinase kinase 7
Gene
MAP2K7
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein serine/threonine kinase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Enzyme and pathway databases

    SignaLinkiF6WCX7.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Dual-specificity mitogen-activated protein kinase kinase 7Imported
    Gene namesi
    Name:MAP2K7Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6847. MAP2K7.

    PTM / Processingi

    Proteomic databases

    PRIDEiF6WCX7.

    Expressioni

    Gene expression databases

    ArrayExpressiF6WCX7.
    BgeeiF6WCX7.

    Structurei

    3D structure databases

    ProteinModelPortaliF6WCX7.
    SMRiF6WCX7. Positions 123-444.

    Family & Domainsi

    Phylogenomic databases

    OMAiPIIVIQL.
    PhylomeDBiF6WCX7.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6WCX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PTLQLPLAND    50
    GGSRSPSSES SPQHPTPPAR PRHMLGLPST LFTPRSMESI EIDQKLQEIM 100
    KQTGYLTIGG QVPPSLWRGE GGGPARLDPS WERQWGAGGG GRPGTLQPSL 150
    SSQRYQAEIN DLENLGEMGS GTCGQVWKMR FRKTGHVIAV KQMRRSGNKE 200
    ENKRILMDLD VVLKSHDCPY IVQCFGTFIT NTDVFIAMEL MGTCAEKLKK 250
    RMQGPIPERI LGKMTVAIVK ALYYLKEKHG VIHRDVKPSN ILLDERGQIK 300
    LCDFGISGRL VDSKAKTRSA GCAAYMAPER IDPPDPTKPD YDIRADVWSL 350
    GISLVELATG QFPYKNCKTD FEVLTKVLQE EPPLLPGHMG FSGDFQSFVK 400
    DCLTKDHRKR PKYNKLLEHS FIKRYETLEV DVASWFKDVM AKTESPRTSG 450
    VLSQPHLPFF R 461
    Length:461
    Mass (Da):51,810
    Last modified:July 27, 2011 - v1
    Checksum:iD53B8CF9CD6F8C0C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010336 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000545011; ENSP00000443946; ENSG00000076984.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010336 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali F6WCX7.
    SMRi F6WCX7. Positions 123-444.
    ModBasei Search...

    Proteomic databases

    PRIDEi F6WCX7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000545011 ; ENSP00000443946 ; ENSG00000076984 .

    Organism-specific databases

    HGNCi HGNC:6847. MAP2K7.
    GenAtlasi Search...

    Phylogenomic databases

    OMAi PIIVIQL.
    PhylomeDBi F6WCX7.

    Enzyme and pathway databases

    SignaLinki F6WCX7.

    Miscellaneous databases

    NextBioi 35510447.

    Gene expression databases

    ArrayExpressi F6WCX7.
    Bgeei F6WCX7.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiF6WCX7_HUMAN
    AccessioniPrimary (citable) accession number: F6WCX7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: June 11, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3

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