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F6W2R2 (DMRT3_HORSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Doublesex and mab-3 related transcription factor 3
Gene names
Name:DMRT3
OrganismEquus caballus (Horse) [Reference proteome]
Taxonomic identifier9796 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within a specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development. Ref.1

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in the spinal cord, in a small population of neurons located in the ventral horn and around the central canal. Ref.1

Polymorphism

This sequence corresponds to the wild-type form. A truncated allele, allele A (AC J7FCF0), is linked to the ability to perform alternate gaits, which can be either pace or four-beat ambling gaits. The allele A sequence (AC J7FCF0) has a favorable effect on harness racing performance and on the diversification of the domestic horse, as the altered gait characteristics of a number of breeds apparently require this mutation. Homozygosity for the mutation is required, but not sufficient for pacing, as many Standardbred trotters and some Icelandic horses that are homozygous for this mutation do not pace. The allele A is not found in the following horse populations: Arabian horse, Gotland pony, North-Swedish draft horse, Przewalski's horse, Shetland pony, Swedish ardennes, Swedish warmblood and Thoroughbred.

Miscellaneous

DMRT3 is a marker for a subset of spinal cord neurons (dI6).

Sequence similarities

Belongs to the DMRT family.

Contains 1 DM DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474Doublesex and mab-3 related transcription factor 3
PRO_0000422701

Regions

DNA binding29 – 7648DM
Compositional bias95 – 12531Pro-rich

Sequences

Sequence LengthMass (Da)Tools
F6W2R2 [UniParc].

Last modified June 26, 2013. Version 2.
Checksum: C721D1DDACC433C0

FASTA47451,418
        10         20         30         40         50         60 
MNGYGSPYLY MGGPVSQPPR APLQRTPKCA RCRNHGVLSW LKGHKRYCRF KDCTCEKCIL 

        70         80         90        100        110        120 
IIERQRVMAA QVALRRQQAN ESLESLIPDS LRALPGPPPP GDAAAAAPQP PPTSQPSQPP 

       130        140        150        160        170        180 
PPQRPAAELA AAAALRWATE PQPGALQAQL AKPDLTEERL GDGSSADNTE TFSDKDTDQR 

       190        200        210        220        230        240 
SSPDVVKSKG CFTPESPEVV SVDEGGYAVQ KNGGTSESRP DSPKYHGEQN HLLIEGPSGT 

       250        260        270        280        290        300 
VSLPFSLKAN RPPLEVLKKI FPNQKPTVLE LILKGCGGDL VSAVEVLLSS RSSASAADRT 

       310        320        330        340        350        360 
SAEPESLVLP SNGHIFEHTL SSYPISSSKW SVGSAFRVPD TLRFSADSSN VVPNPLAVPL 

       370        380        390        400        410        420 
QHPFPQPPRY PLMLRNTLAR NQSSPFLPND VTLWNTMTLQ QQYQLRSQYV SPFPGSSPSV 

       430        440        450        460        470 
FRSSPVLPTR APEDPRISIP DDGCPIVSKQ SLYTEDDYDE RSDSSDSRIL NTSS 

« Hide

References

« Hide 'large scale' references
[1]"Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice."
Andersson L.S., Larhammar M., Memic F., Wootz H., Schwochow D., Rubin C.-J., Patra K., Arnason T., Wellbring L., Hjalm G., Imsland F., Petersen J.L., McCue M.E., Mickelson J.R., Cothran G., Ahituv N., Roepstorff L., Mikko S. expand/collapse author list , Vallstedt A., Lindgren G., Andersson L., Kullander K.
Nature 488:642-646(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY, POLYMORPHISM.
Strain: Thoroughbred.
[2]"Genome sequence, comparative analysis, and population genetics of the domestic horse."
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T. expand/collapse author list , Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.
Science 326:865-867(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Thoroughbred.

Web resources

Protein Spotlight

A gait on the wildside - Issue 154 of November 2013

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
JQ922365 Genomic DNA. Translation: AFK83802.1.
JQ922367 Genomic DNA. Translation: AFK83804.1.
JQ922371 mRNA. Translation: AFK83806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG7TXKGH.

Family and domain databases

Gene3D4.10.1040.10. 1 hit.
InterProIPR001275. DM_DNA-bd.
IPR005173. DMA.
IPR026607. DMRT/dsx/mab-3.
IPR009060. UBA-like.
[Graphical view]
PANTHERPTHR12322. PTHR12322. 1 hit.
PfamPF00751. DM. 1 hit.
PF03474. DMA. 1 hit.
[Graphical view]
SMARTSM00301. DM. 1 hit.
[Graphical view]
SUPFAMSSF46934. SSF46934. 1 hit.
SSF82927. SSF82927. 1 hit.
PROSITEPS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDMRT3_HORSE
AccessionPrimary (citable) accession number: F6W2R2
Secondary accession number(s): J3SGP7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: June 26, 2013
Last modified: May 14, 2014
This is version 17 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries