Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

F6W2R2

- DMRT3_HORSE

UniProt

F6W2R2 - DMRT3_HORSE

Protein

Doublesex and mab-3 related transcription factor 3

Gene

DMRT3

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 2 (26 Jun 2013)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within a specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi29 – 7648DMPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. sex differentiation Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Sexual differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Doublesex and mab-3 related transcription factor 3
    Gene namesi
    Name:DMRT3
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Unplaced

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474Doublesex and mab-3 related transcription factor 3PRO_0000422701Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in the spinal cord, in a small population of neurons located in the ventral horn and around the central canal.1 Publication

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi95 – 12531Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DMRT family.Curated
    Contains 1 DM DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    OrthoDBiEOG7TXKGH.

    Family and domain databases

    Gene3Di4.10.1040.10. 1 hit.
    InterProiIPR001275. DM_DNA-bd.
    IPR005173. DMA.
    IPR026607. DMRT/dsx/mab-3.
    IPR009060. UBA-like.
    [Graphical view]
    PANTHERiPTHR12322. PTHR12322. 1 hit.
    PfamiPF00751. DM. 1 hit.
    PF03474. DMA. 1 hit.
    [Graphical view]
    SMARTiSM00301. DM. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    SSF82927. SSF82927. 1 hit.
    PROSITEiPS40000. DM_1. 1 hit.
    PS50809. DM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6W2R2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNGYGSPYLY MGGPVSQPPR APLQRTPKCA RCRNHGVLSW LKGHKRYCRF    50
    KDCTCEKCIL IIERQRVMAA QVALRRQQAN ESLESLIPDS LRALPGPPPP 100
    GDAAAAAPQP PPTSQPSQPP PPQRPAAELA AAAALRWATE PQPGALQAQL 150
    AKPDLTEERL GDGSSADNTE TFSDKDTDQR SSPDVVKSKG CFTPESPEVV 200
    SVDEGGYAVQ KNGGTSESRP DSPKYHGEQN HLLIEGPSGT VSLPFSLKAN 250
    RPPLEVLKKI FPNQKPTVLE LILKGCGGDL VSAVEVLLSS RSSASAADRT 300
    SAEPESLVLP SNGHIFEHTL SSYPISSSKW SVGSAFRVPD TLRFSADSSN 350
    VVPNPLAVPL QHPFPQPPRY PLMLRNTLAR NQSSPFLPND VTLWNTMTLQ 400
    QQYQLRSQYV SPFPGSSPSV FRSSPVLPTR APEDPRISIP DDGCPIVSKQ 450
    SLYTEDDYDE RSDSSDSRIL NTSS 474
    Length:474
    Mass (Da):51,418
    Last modified:June 26, 2013 - v2
    Checksum:iC721D1DDACC433C0
    GO

    Polymorphismi

    This sequence corresponds to the wild-type form. A truncated allele, allele A (AC J7FCF0), is linked to the ability to perform alternate gaits, which can be either pace or four-beat ambling gaits. The allele A sequence (AC J7FCF0) has a favorable effect on harness racing performance and on the diversification of the domestic horse, as the altered gait characteristics of a number of breeds apparently require this mutation. Homozygosity for the mutation is required, but not sufficient for pacing, as many Standardbred trotters and some Icelandic horses that are homozygous for this mutation do not pace. The allele A is not found in the following horse populations: Arabian horse, Gotland pony, North-Swedish draft horse, Przewalski's horse, Shetland pony, Swedish ardennes, Swedish warmblood and Thoroughbred.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JQ922365 Genomic DNA. Translation: AFK83802.1.
    JQ922367 Genomic DNA. Translation: AFK83804.1.
    JQ922371 mRNA. Translation: AFK83806.1.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    A gait on the wildside - Issue 154 of November 2013

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JQ922365 Genomic DNA. Translation: AFK83802.1 .
    JQ922367 Genomic DNA. Translation: AFK83804.1 .
    JQ922371 mRNA. Translation: AFK83806.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG7TXKGH.

    Family and domain databases

    Gene3Di 4.10.1040.10. 1 hit.
    InterProi IPR001275. DM_DNA-bd.
    IPR005173. DMA.
    IPR026607. DMRT/dsx/mab-3.
    IPR009060. UBA-like.
    [Graphical view ]
    PANTHERi PTHR12322. PTHR12322. 1 hit.
    Pfami PF00751. DM. 1 hit.
    PF03474. DMA. 1 hit.
    [Graphical view ]
    SMARTi SM00301. DM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    SSF82927. SSF82927. 1 hit.
    PROSITEi PS40000. DM_1. 1 hit.
    PS50809. DM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY, POLYMORPHISM.
      Strain: Thoroughbred.
    2. "Genome sequence, comparative analysis, and population genetics of the domestic horse."
      Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.
      , Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.
      Science 326:865-867(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Thoroughbred.

    Entry informationi

    Entry nameiDMRT3_HORSE
    AccessioniPrimary (citable) accession number: F6W2R2
    Secondary accession number(s): J3SGP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2013
    Last sequence update: June 26, 2013
    Last modified: October 1, 2014
    This is version 18 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    DMRT3 is a marker for a subset of spinal cord neurons (dI6).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3