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Protein

Doublesex and mab-3 related transcription factor 3

Gene

DMRT3

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within a specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi29 – 7648DMPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Sexual differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Doublesex and mab-3 related transcription factor 3
Gene namesi
Name:DMRT3
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Doublesex and mab-3 related transcription factor 3PRO_0000422701Add
BLAST

Expressioni

Tissue specificityi

Expressed in the spinal cord, in a small population of neurons located in the ventral horn and around the central canal.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000020841.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 12531Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the DMRT family.Curated
Contains 1 DM DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiF6W2R2.
OrthoDBiEOG7TXKGH.

Family and domain databases

Gene3Di4.10.1040.10. 1 hit.
InterProiIPR001275. DM_DNA-bd.
IPR005173. DMA.
IPR026607. DMRT/dsx/mab-3.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR12322. PTHR12322. 1 hit.
PfamiPF00751. DM. 1 hit.
PF03474. DMA. 1 hit.
[Graphical view]
SMARTiSM00301. DM. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF82927. SSF82927. 1 hit.
PROSITEiPS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6W2R2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGYGSPYLY MGGPVSQPPR APLQRTPKCA RCRNHGVLSW LKGHKRYCRF
60 70 80 90 100
KDCTCEKCIL IIERQRVMAA QVALRRQQAN ESLESLIPDS LRALPGPPPP
110 120 130 140 150
GDAAAAAPQP PPTSQPSQPP PPQRPAAELA AAAALRWATE PQPGALQAQL
160 170 180 190 200
AKPDLTEERL GDGSSADNTE TFSDKDTDQR SSPDVVKSKG CFTPESPEVV
210 220 230 240 250
SVDEGGYAVQ KNGGTSESRP DSPKYHGEQN HLLIEGPSGT VSLPFSLKAN
260 270 280 290 300
RPPLEVLKKI FPNQKPTVLE LILKGCGGDL VSAVEVLLSS RSSASAADRT
310 320 330 340 350
SAEPESLVLP SNGHIFEHTL SSYPISSSKW SVGSAFRVPD TLRFSADSSN
360 370 380 390 400
VVPNPLAVPL QHPFPQPPRY PLMLRNTLAR NQSSPFLPND VTLWNTMTLQ
410 420 430 440 450
QQYQLRSQYV SPFPGSSPSV FRSSPVLPTR APEDPRISIP DDGCPIVSKQ
460 470
SLYTEDDYDE RSDSSDSRIL NTSS
Length:474
Mass (Da):51,418
Last modified:June 26, 2013 - v2
Checksum:iC721D1DDACC433C0
GO

Polymorphismi

This sequence corresponds to the wild-type form. A truncated allele, allele A (AC J7FCF0), is linked to the ability to perform alternate gaits, which can be either pace or four-beat ambling gaits. The allele A sequence (AC J7FCF0) has a favorable effect on harness racing performance and on the diversification of the domestic horse, as the altered gait characteristics of a number of breeds apparently require this mutation. Homozygosity for the mutation is required, but not sufficient for pacing, as many Standardbred trotters and some Icelandic horses that are homozygous for this mutation do not pace. The allele A is not found in the following horse populations: Arabian horse, Gotland pony, North-Swedish draft horse, Przewalski's horse, Shetland pony, Swedish ardennes, Swedish warmblood and Thoroughbred.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ922365 Genomic DNA. Translation: AFK83802.1.
JQ922367 Genomic DNA. Translation: AFK83804.1.
JQ922371 mRNA. Translation: AFK83806.1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

A gait on the wildside - Issue 154 of November 2013

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ922365 Genomic DNA. Translation: AFK83802.1.
JQ922367 Genomic DNA. Translation: AFK83804.1.
JQ922371 mRNA. Translation: AFK83806.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000020841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

InParanoidiF6W2R2.
OrthoDBiEOG7TXKGH.

Family and domain databases

Gene3Di4.10.1040.10. 1 hit.
InterProiIPR001275. DM_DNA-bd.
IPR005173. DMA.
IPR026607. DMRT/dsx/mab-3.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR12322. PTHR12322. 1 hit.
PfamiPF00751. DM. 1 hit.
PF03474. DMA. 1 hit.
[Graphical view]
SMARTiSM00301. DM. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF82927. SSF82927. 1 hit.
PROSITEiPS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY, POLYMORPHISM.
    Strain: Thoroughbred.
  2. "Genome sequence, comparative analysis, and population genetics of the domestic horse."
    Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.
    , Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.
    Science 326:865-867(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Thoroughbred.

Entry informationi

Entry nameiDMRT3_HORSE
AccessioniPrimary (citable) accession number: F6W2R2
Secondary accession number(s): J3SGP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: June 26, 2013
Last modified: June 24, 2015
This is version 21 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

DMRT3 is a marker for a subset of spinal cord neurons (dI6).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.