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Protein
Submitted name:

Probable global transcription activator SNF2L2

Gene

SMARCA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Probable global transcription activator SNF2L2Imported
Gene namesi
Name:SMARCA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000080503.20.
HGNCiHGNC:11098. SMARCA2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000080503.

PTM / Processingi

Proteomic databases

PaxDbiF6VDE0.
PeptideAtlasiF6VDE0.
PRIDEiF6VDE0.

Expressioni

Gene expression databases

BgeeiENSG00000080503.
ExpressionAtlasiF6VDE0. baseline and differential.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini173 – 208QLQInterPro annotationAdd BLAST36
Domaini436 – 508HSAInterPro annotationAdd BLAST73
Domaini736 – 889Helicase ATP-bindingInterPro annotationAdd BLAST154
Domaini996 – 1158Helicase C-terminalInterPro annotationAdd BLAST163
Domaini1343 – 1413BromoInterPro annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili212 – 238Sequence analysisAdd BLAST27
Coiled coili547 – 570Sequence analysisAdd BLAST24
Coiled coili1423 – 1453Sequence analysisAdd BLAST31

Keywords - Domaini

BromodomainPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0386. Eukaryota.
COG0553. LUCA.
COG5076. LUCA.
GeneTreeiENSGT00550000074659.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
Gene3Di1.20.920.10. 2 hits.
2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR006576. BRK_domain.
IPR001487. Bromodomain.
IPR036427. Bromodomain-like_sf.
IPR018359. Bromodomain_CS.
IPR014978. Gln-Leu-Gln_QLQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR030088. SMARCA2.
IPR029295. SnAC.
IPR000330. SNF2_N.
IPR015943. WD40/YVTN_repeat-like_dom.
PANTHERiPTHR10799:SF541. PTHR10799:SF541. 3 hits.
PfamiView protein in Pfam
PF07533. BRK. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF08880. QLQ. 1 hit.
PF14619. SnAC. 1 hit.
PF00176. SNF2_N. 2 hits.
PRINTSiPR00503. BROMODOMAIN.
SMARTiView protein in SMART
SM00592. BRK. 1 hit.
SM00297. BROMO. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
SM00951. QLQ. 1 hit.
SM01314. SnAC. 1 hit.
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS51666. QLQ. 1 hit.

Sequencei

Sequence statusi: Complete.

F6VDE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPTDPGAM PHPGPSPGPG PSPGPILGPS PGPGPSPGSV HSMMGPSPGP
60 70 80 90 100
PSVSHPMPTM GSTDFPQEGM HQMHKPIDGI HDKGIVEDIH CGSMKGTGMR
110 120 130 140 150
PPHPGMGPPQ SPMDQHSQGY MSPHPSPLGA PEHVSSPMSG GGPTPPQMPP
160 170 180 190 200
SQPGALIPGD PQAMSQPNRG PSPFSPVQLH QLRAQILAYK MLARGQPLPE
210 220 230 240 250
TLQLAVQGKR TLPGLQQQQQ QQQQQQQQQQ QQQQQQQQPQ QQPPQPQTQQ
260 270 280 290 300
QQQPALVNYN RPSGPGPELS GPSTPQKLPV PAPGGRPSPA PPAAAQPPAA
310 320 330 340 350
AVPGPSVPQP APGQPSPVLQ LQQKQSRISP IQKPQGLDPV EILQEREYRL
360 370 380 390 400
QARIAHRIQE LENLPGSLPP DLRTKATVEL KALRLLNFQR QLRQEVVACM
410 420 430 440 450
RRDTTLETAL NSKAYKRSKR QTLREARMTE KLEKQQKIEQ ERKRRQKHQE
460 470 480 490 500
YLNSILQHAK DFKEYHRSVA GKIQKLSKAV ATWHANTERE QKKETERIEK
510 520 530 540 550
ERMRRLMAED EEGYRKLIDQ KKDRRLAYLL QQTDEYVANL TNLVWEHKQA
560 570 580 590 600
QAAKEKKKRR RRKKKAEENA EGGESALGPD GEPIDESSQM SDLPVKVTHT
610 620 630 640 650
ETGKVLFGPE APKASQLDAW LEMNPGYEVA PRSDSEESDS DYEEEDEEEE
660 670 680 690 700
SSRQETEEKI LLDPNSEEVS EKDAKQIIET AKQDVDDEYS MQYSARGSQS
710 720 730 740 750
YYTVAHAISE RVEKQSALLI NGTLKHYQLQ GLEWMVSLYN NNLNGILADE
760 770 780 790 800
MGLGKTIQTI ALITYLMEHK RLNGPYLIIV PLSTLSNWTY EFDKWAPSVV
810 820 830 840 850
KISYKGTPAM RRSLVPQLRS GKFNVLLTTY EYIIKDKHIL AKIRWKYMIV
860 870 880 890 900
DEGHRMKNHH CKLTQVDLNE EETILIIRRL HKVLRPFLLR RLKKEVESQL
910 920 930 940 950
PEKVEYVIKC DMSALQKILY RHMQAKGILL TDGSEKDKKG KGGAKTLMNT
960 970 980 990 1000
IMQLRKICNH PYMFQHIEES FAEHLGYSNG VINGAELYRA SGKFELLDRI
1010 1020 1030 1040 1050
LPKLRATNHR VLLFCQMTSL MTIMEDYFAF RNFLYLRLDG TTKSEDRAAL
1060 1070 1080 1090 1100
LKKFNEPGSQ YFIFLLSTRA GGLGLNLQAA DTVVIFDSDW NPHQDLQAQD
1110 1120 1130 1140 1150
RAHRIGQQNE VRVLRLCTVN SVEEKILAAA KYKLNVDQKV IQAGMFDQKS
1160 1170 1180 1190 1200
SSHERRAFLQ AILEHEEENE EEDEVPDDET LNQMIARREE EFDLFMRMDM
1210 1220 1230 1240 1250
DRRREDARNP KRKPRLMEED ELPSWIIKDD AEVERLTCEE EEEKIFGRGS
1260 1270 1280 1290 1300
RQRRDVDYSD ALTEKQWLRA IEDGNLEEME EEVRLKKRKR RRNVDKDPAK
1310 1320 1330 1340 1350
EDVEKAKKRR GRPPAEKLSP NPPKLTKQMN AIIDTVINYK DSSGRQLSEV
1360 1370 1380 1390 1400
FIQLPSRKEL PEYYELIRKP VDFKKIKERI RNHKYRSLGD LEKDVMLLCH
1410 1420 1430 1440 1450
NAQTFNLEGS QIYEDSIVLQ SVFKSARQKI AKEEESEDES NEEEEEEDEE
1460 1470 1480 1490 1500
ESESEAKSVK VKIKLNKKDD KGRDKGKGKK RPNRGKAKPV VSDFDSDEEQ
1510
DEREQSEGSG TDDE
Length:1,514
Mass (Da):172,592
Last modified:February 17, 2016 - v2
Checksum:i77255AC165E51BE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138755 Genomic DNA. No translation available.
AL359076 Genomic DNA. No translation available.
AL591644 Genomic DNA. No translation available.
RefSeqiNP_001276326.1. NM_001289397.1.
UniGeneiHs.298990.
Hs.644901.

Genome annotation databases

EnsembliENST00000450198; ENSP00000392081; ENSG00000080503.
GeneIDi6595.
UCSCiuc064rwa.1. human.

Similar proteinsi

Entry informationi

Entry nameiF6VDE0_HUMAN
AccessioniPrimary (citable) accession number: F6VDE0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: February 17, 2016
Last modified: October 25, 2017
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported