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F6V6I0 (UBP13_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 13

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 13
Ubiquitin thioesterase 13
Ubiquitin-specific-processing protease 13
Gene names
Name:usp13
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length846 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme regulation

Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative of MBCQ that binds to usp13 and inhibits deubiquitinase activity By similarity.

Domain

The UBP-type zinc finger has lost its ability to bind ubiquitin and usp13 is not activated by unanchored ubiquitin By similarity.

The UBA domains mediate binding to ubiquitin By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 2 UBA domains.

Contains 1 UBP-type zinc finger.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 846846Ubiquitin carboxyl-terminal hydrolase 13
PRO_0000418014

Regions

Domain317 – 844528USP
Domain633 – 67644UBA 1
Domain708 – 74841UBA 2
Zinc finger190 – 26273UBP-type

Sites

Active site8061Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
F6V6I0 [UniParc].

Last modified June 13, 2012. Version 2.
Checksum: 139B256C047BE39A

FASTA84695,089
        10         20         30         40         50         60 
MAEDLGELLV PYMPTIRVPK SGDRVYKTEC AFSYDSPESD GGLYVCMSTF LGFGREHVER 

        70         80         90        100        110        120 
HYRKTGQSVY MHLKRHIRLK ATGASGGAFP KRINGRLFLD LENNTEMNTE DYEYEDEAKL 

       130        140        150        160        170        180 
VIFPDHFEIA LPNIEELPAL VTIACDAVLN SKSPYRKLDQ ESWEEELQVS KFANNLVQID 

       190        200        210        220        230        240 
NGVKIPPSGW KCSKCDLQEN LWLNLTDGSI MCGRWFCSGS GGNGHALEHH KQMGYPLAVR 

       250        260        270        280        290        300 
LGSITPDGAD VYSFDEEEAV IDPHLAKHLA HFGIDMLQMQ GSENGVLDNE VKPRVNEWEV 

       310        320        330        340        350        360 
IQETGLKLKP MFGSGYTGIK NLGNSSYLTT VMQVIFSIPE FQRAYVGNLT RIFDYAPLDP 

       370        380        390        400        410        420 
TQDFSTQMAK LGHGLLSGQF SKPPMKSELI EQVMKEEHKP QPKGINTRMF KALMSKGHTE 

       430        440        450        460        470        480 
FSSNRQQDAE EFFLHFINLV ERNSIGAENP SDVFRFLVEE RTQCCQSRKV RYTERVDYIM 

       490        500        510        520        530        540 
QLPVPMETAT NKEELIAYDL KRREAESAKR PPPELVRAKI PFSACLQAFT EPENVPDFWS 

       550        560        570        580        590        600 
SALQAKSAGV KTSRFASFPE YLVVQIKKFT FGLDWVPKKL DVSIDMPDLL DINHLRATGL 

       610        620        630        640        650        660 
KSGEEELPDI APPIIIPDDP NGRMAESLLS GSGSNVNSSF KGAQPLNLPF GKKEAKLLRY 

       670        680        690        700        710        720 
MERMVEKFGF KFSVRLSVEI DFAEPLIIPG CGTVTSTSSH GQNALLNQPP EEIVALICSM 

       730        740        750        760        770        780 
GFPRNHALQA LRATNNNLER ALDWMFSHPE SEEGADNVSG CVDTENNPNG IITDSEQEGP 

       790        800        810        820        830        840 
RIKDGNGRYE LFGIISHAGT STMSGHYVCH IKKEGRWVIY NDHKVSASER PPKELGYIYF 


YHRISC 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAMC01001929 Genomic DNA. No translation available.
AAMC01001930 Genomic DNA. No translation available.
AAMC01001931 Genomic DNA. No translation available.
AAMC01001932 Genomic DNA. No translation available.
AAMC01001933 Genomic DNA. No translation available.
AAMC01001934 Genomic DNA. No translation available.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR016652. Ubiquitinyl_hydrolase.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamPF00627. UBA. 1 hit.
PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PIRSFPIRSF016308. UBP. 1 hit.
SMARTSM00165. UBA. 1 hit.
SM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEPS50030. UBA. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP13_XENTR
AccessionPrimary (citable) accession number: F6V6I0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: June 13, 2012
Last modified: May 14, 2014
This is version 22 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries