Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

F6V6I0

- UBP13_XENTR

UniProt

F6V6I0 - UBP13_XENTR

Protein

Ubiquitin carboxyl-terminal hydrolase 13

Gene

usp13

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 2 (13 Jun 2012)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD).By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Enzyme regulationi

    Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative of MBCQ that binds to usp13 and inhibits deubiquitinase activity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei806 – 8061Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri190 – 26273UBP-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: UniProtKB
    2. omega peptidase activity Source: InterPro
    3. ubiquitin binding Source: UniProtKB
    4. ubiquitin-specific protease activity Source: UniProtKB
    5. ubiquitin thiolesterase activity Source: UniProtKB
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. cell proliferation Source: UniProtKB
    3. protein K63-linked deubiquitination Source: UniProtKB
    4. protein stabilization Source: UniProtKB
    5. regulation of autophagy Source: UniProtKB
    6. regulation of transcription, DNA-templated Source: UniProtKB
    7. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Autophagy, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 13 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 13
    Ubiquitin thioesterase 13
    Ubiquitin-specific-processing protease 13
    Gene namesi
    Name:usp13
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 846846Ubiquitin carboxyl-terminal hydrolase 13PRO_0000418014Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini317 – 844528USPAdd
    BLAST
    Domaini633 – 67644UBA 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini708 – 74841UBA 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The UBP-type zinc finger has lost its ability to bind ubiquitin and usp13 is not activated by unanchored ubiquitin.By similarity
    The UBA domains mediate binding to ubiquitin.By similarity

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 2 UBA domains.PROSITE-ProRule annotation
    Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri190 – 26273UBP-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000449. UBA/Ts_N.
    IPR016652. Ubiquitinyl_hydrolase.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view]
    PfamiPF00627. UBA. 1 hit.
    PF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016308. UBP. 1 hit.
    SMARTiSM00165. UBA. 1 hit.
    SM00290. ZnF_UBP. 1 hit.
    [Graphical view]
    PROSITEiPS50030. UBA. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6V6I0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEDLGELLV PYMPTIRVPK SGDRVYKTEC AFSYDSPESD GGLYVCMSTF    50
    LGFGREHVER HYRKTGQSVY MHLKRHIRLK ATGASGGAFP KRINGRLFLD 100
    LENNTEMNTE DYEYEDEAKL VIFPDHFEIA LPNIEELPAL VTIACDAVLN 150
    SKSPYRKLDQ ESWEEELQVS KFANNLVQID NGVKIPPSGW KCSKCDLQEN 200
    LWLNLTDGSI MCGRWFCSGS GGNGHALEHH KQMGYPLAVR LGSITPDGAD 250
    VYSFDEEEAV IDPHLAKHLA HFGIDMLQMQ GSENGVLDNE VKPRVNEWEV 300
    IQETGLKLKP MFGSGYTGIK NLGNSSYLTT VMQVIFSIPE FQRAYVGNLT 350
    RIFDYAPLDP TQDFSTQMAK LGHGLLSGQF SKPPMKSELI EQVMKEEHKP 400
    QPKGINTRMF KALMSKGHTE FSSNRQQDAE EFFLHFINLV ERNSIGAENP 450
    SDVFRFLVEE RTQCCQSRKV RYTERVDYIM QLPVPMETAT NKEELIAYDL 500
    KRREAESAKR PPPELVRAKI PFSACLQAFT EPENVPDFWS SALQAKSAGV 550
    KTSRFASFPE YLVVQIKKFT FGLDWVPKKL DVSIDMPDLL DINHLRATGL 600
    KSGEEELPDI APPIIIPDDP NGRMAESLLS GSGSNVNSSF KGAQPLNLPF 650
    GKKEAKLLRY MERMVEKFGF KFSVRLSVEI DFAEPLIIPG CGTVTSTSSH 700
    GQNALLNQPP EEIVALICSM GFPRNHALQA LRATNNNLER ALDWMFSHPE 750
    SEEGADNVSG CVDTENNPNG IITDSEQEGP RIKDGNGRYE LFGIISHAGT 800
    STMSGHYVCH IKKEGRWVIY NDHKVSASER PPKELGYIYF YHRISC 846
    Length:846
    Mass (Da):95,089
    Last modified:June 13, 2012 - v2
    Checksum:i139B256C047BE39A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAMC01001929 Genomic DNA. No translation available.
    AAMC01001930 Genomic DNA. No translation available.
    AAMC01001931 Genomic DNA. No translation available.
    AAMC01001932 Genomic DNA. No translation available.
    AAMC01001933 Genomic DNA. No translation available.
    AAMC01001934 Genomic DNA. No translation available.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAMC01001929 Genomic DNA. No translation available.
    AAMC01001930 Genomic DNA. No translation available.
    AAMC01001931 Genomic DNA. No translation available.
    AAMC01001932 Genomic DNA. No translation available.
    AAMC01001933 Genomic DNA. No translation available.
    AAMC01001934 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    IPR000449. UBA/Ts_N.
    IPR016652. Ubiquitinyl_hydrolase.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view ]
    Pfami PF00627. UBA. 1 hit.
    PF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016308. UBP. 1 hit.
    SMARTi SM00165. UBA. 1 hit.
    SM00290. ZnF_UBP. 1 hit.
    [Graphical view ]
    PROSITEi PS50030. UBA. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiUBP13_XENTR
    AccessioniPrimary (citable) accession number: F6V6I0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2012
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 23 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3