Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin carboxyl-terminal hydrolase 13

Gene

usp13

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Deubiquitinase that mediates deubiquitination of target proteins and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Enzyme regulationi

Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative of MBCQ that binds to usp13 and inhibits deubiquitinase activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei806Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 262UBP-typePROSITE-ProRule annotationAdd BLAST73

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processAutophagy, Ubl conjugation pathway
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 13 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 13
Ubiquitin thioesterase 13
Ubiquitin-specific-processing protease 13
Gene namesi
Name:usp13
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004180141 – 846Ubiquitin carboxyl-terminal hydrolase 13Add BLAST846

Proteomic databases

PaxDbiF6V6I0
PRIDEiF6V6I0

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000015787

Structurei

3D structure databases

SMRiF6V6I0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini317 – 844USPAdd BLAST528
Domaini633 – 676UBA 1PROSITE-ProRule annotationAdd BLAST44
Domaini708 – 748UBA 2PROSITE-ProRule annotationAdd BLAST41

Domaini

The UBP-type zinc finger has lost its ability to bind ubiquitin and usp13 is not activated by unanchored ubiquitin.By similarity
The UBA domains mediate binding to ubiquitin.By similarity

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 262UBP-typePROSITE-ProRule annotationAdd BLAST73

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0944 Eukaryota
COG5207 LUCA
InParanoidiF6V6I0
OrthoDBiEOG091G01W3

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR015940 UBA
IPR016652 Ubiquitinyl_hydrolase
IPR018200 USP_CS
IPR028889 USP_dom
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PfamiView protein in Pfam
PF00627 UBA, 1 hit
PF00443 UCH, 1 hit
PF02148 zf-UBP, 1 hit
PIRSFiPIRSF016308 UBP, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 1 hit
SM00290 ZnF_UBP, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS50271 ZF_UBP, 1 hit

Sequencei

Sequence statusi: Complete.

F6V6I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDLGELLV PYMPTIRVPK SGDRVYKTEC AFSYDSPESD GGLYVCMSTF
60 70 80 90 100
LGFGREHVER HYRKTGQSVY MHLKRHIRLK ATGASGGAFP KRINGRLFLD
110 120 130 140 150
LENNTEMNTE DYEYEDEAKL VIFPDHFEIA LPNIEELPAL VTIACDAVLN
160 170 180 190 200
SKSPYRKLDQ ESWEEELQVS KFANNLVQID NGVKIPPSGW KCSKCDLQEN
210 220 230 240 250
LWLNLTDGSI MCGRWFCSGS GGNGHALEHH KQMGYPLAVR LGSITPDGAD
260 270 280 290 300
VYSFDEEEAV IDPHLAKHLA HFGIDMLQMQ GSENGVLDNE VKPRVNEWEV
310 320 330 340 350
IQETGLKLKP MFGSGYTGIK NLGNSSYLTT VMQVIFSIPE FQRAYVGNLT
360 370 380 390 400
RIFDYAPLDP TQDFSTQMAK LGHGLLSGQF SKPPMKSELI EQVMKEEHKP
410 420 430 440 450
QPKGINTRMF KALMSKGHTE FSSNRQQDAE EFFLHFINLV ERNSIGAENP
460 470 480 490 500
SDVFRFLVEE RTQCCQSRKV RYTERVDYIM QLPVPMETAT NKEELIAYDL
510 520 530 540 550
KRREAESAKR PPPELVRAKI PFSACLQAFT EPENVPDFWS SALQAKSAGV
560 570 580 590 600
KTSRFASFPE YLVVQIKKFT FGLDWVPKKL DVSIDMPDLL DINHLRATGL
610 620 630 640 650
KSGEEELPDI APPIIIPDDP NGRMAESLLS GSGSNVNSSF KGAQPLNLPF
660 670 680 690 700
GKKEAKLLRY MERMVEKFGF KFSVRLSVEI DFAEPLIIPG CGTVTSTSSH
710 720 730 740 750
GQNALLNQPP EEIVALICSM GFPRNHALQA LRATNNNLER ALDWMFSHPE
760 770 780 790 800
SEEGADNVSG CVDTENNPNG IITDSEQEGP RIKDGNGRYE LFGIISHAGT
810 820 830 840
STMSGHYVCH IKKEGRWVIY NDHKVSASER PPKELGYIYF YHRISC
Length:846
Mass (Da):95,089
Last modified:June 13, 2012 - v2
Checksum:i139B256C047BE39A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01001929 Genomic DNA No translation available.
AAMC01001930 Genomic DNA No translation available.
AAMC01001931 Genomic DNA No translation available.
AAMC01001932 Genomic DNA No translation available.
AAMC01001933 Genomic DNA No translation available.
AAMC01001934 Genomic DNA No translation available.

Similar proteinsi

Entry informationi

Entry nameiUBP13_XENTR
AccessioniPrimary (citable) accession number: F6V6I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: June 13, 2012
Last modified: May 23, 2018
This is version 39 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health