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F6V515 (MTAP_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
S-methyl-5'-thioadenosine phosphorylase

EC=2.4.2.28
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name=MTA phosphorylase
Short name=MTAP
Short name=MTAPase
Gene names
Name:mtap
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity. HAMAP-Rule MF_03155

Catalytic activity

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_03155

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1. HAMAP-Rule MF_03155

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_03155

Subcellular location

Cytoplasm By similarity. Nucleus By similarity HAMAP-Rule MF_03155.

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
Nucleus
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-methionine salvage from methylthioadenosine

Inferred from electronic annotation. Source: UniProtKB-UniPathway

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionS-methyl-5-thioadenosine phosphorylase activity

Inferred from electronic annotation. Source: UniProtKB-EC

phosphorylase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281S-methyl-5'-thioadenosine phosphorylase HAMAP-Rule MF_03155
PRO_0000415115

Regions

Region58 – 592Phosphate binding By similarity
Region91 – 922Phosphate binding By similarity
Region218 – 2203Substrate binding By similarity

Sites

Binding site151Phosphate By similarity
Binding site1941Substrate; via amide nitrogen By similarity
Binding site1951Phosphate By similarity
Site1761Important for substrate specificity By similarity
Site2311Important for substrate specificity By similarity

Sequences

Sequence LengthMass (Da)Tools
F6V515 [UniParc].

Last modified July 27, 2011. Version 1.
Checksum: 096C64113C943764

FASTA28130,699
        10         20         30         40         50         60 
MAGVCAVKVG IIGGSGLDDP DILEGRLEKY VDTPFGKPSD ALVLGKIKNV DCVLLASRHG 

        70         80         90        100        110        120 
RQHTIAPTNV NYRANIWALK SEGCTHILVT TACGSLREEI QPGDIVIVDQ FIDRTTKREQ 

       130        140        150        160        170        180 
TFYDGGPSCL PGVCHIPMAE PFCAKTREVL IDIAKRLGIK CHSKGAMITI EGPRFSSKAE 

       190        200        210        220        230        240 
SQMFRLWGAD VINMTTVPEV ILAKEAGICY ASIAMATDYD CWKEHEEAVS VDRVLKTLKE 

       250        260        270        280 
NANKATSILL TAIPQIAAMD WTELLQSMKS TVQLSVMLPK H 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAMC01028797 Genomic DNA. No translation available.
AAMC01028798 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalF6V515.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000012027; ENSXETP00000012027; ENSXETG00000005467.

Phylogenomic databases

GeneTreeENSGT00550000074874.
OMAMTNHTEA.
OrthoDBEOG771270.
TreeFamTF312883.

Enzyme and pathway databases

UniPathwayUPA00904; UER00873.

Gene expression databases

BgeeF6V515.

Family and domain databases

Gene3D3.40.50.1580. 1 hit.
HAMAPMF_01963. MTAP.
InterProIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERPTHR11904. PTHR11904. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMSSF53167. SSF53167. 1 hit.
TIGRFAMsTIGR01694. MTAP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMTAP_XENTR
AccessionPrimary (citable) accession number: F6V515
Entry history
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways