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F6V515

- MTAP_XENTR

UniProt

F6V515 - MTAP_XENTR

Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtap

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

    Catalytic activityi

    S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151PhosphateUniRule annotation
    Sitei176 – 1761Important for substrate specificityUniRule annotation
    Binding sitei194 – 1941Substrate; via amide nitrogenUniRule annotation
    Binding sitei195 – 1951PhosphateUniRule annotation
    Sitei231 – 2311Important for substrate specificityUniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    ReactomeiREACT_225119. Methionine salvage pathway.
    UniPathwayiUPA00904; UER00873.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
    Alternative name(s):
    5'-methylthioadenosine phosphorylaseUniRule annotation
    Short name:
    MTA phosphorylaseUniRule annotation
    Short name:
    MTAPUniRule annotation
    Short name:
    MTAPaseUniRule annotation
    Gene namesi
    Name:mtap
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 281281S-methyl-5'-thioadenosine phosphorylasePRO_0000415115Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiF6V515.

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF6V515.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni58 – 592Phosphate bindingUniRule annotation
    Regioni91 – 922Phosphate bindingUniRule annotation
    Regioni218 – 2203Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00550000074874.
    OMAiCEAQLCY.
    OrthoDBiEOG771270.
    TreeFamiTF312883.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01963. MTAP.
    InterProiIPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01694. MTAP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F6V515-1 [UniParc]FASTAAdd to Basket

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    MAGVCAVKVG IIGGSGLDDP DILEGRLEKY VDTPFGKPSD ALVLGKIKNV    50
    DCVLLASRHG RQHTIAPTNV NYRANIWALK SEGCTHILVT TACGSLREEI 100
    QPGDIVIVDQ FIDRTTKREQ TFYDGGPSCL PGVCHIPMAE PFCAKTREVL 150
    IDIAKRLGIK CHSKGAMITI EGPRFSSKAE SQMFRLWGAD VINMTTVPEV 200
    ILAKEAGICY ASIAMATDYD CWKEHEEAVS VDRVLKTLKE NANKATSILL 250
    TAIPQIAAMD WTELLQSMKS TVQLSVMLPK H 281
    Length:281
    Mass (Da):30,699
    Last modified:July 27, 2011 - v1
    Checksum:i096C64113C943764
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAMC01028797 Genomic DNA. No translation available.
    AAMC01028798 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSXETT00000012027; ENSXETP00000012027; ENSXETG00000005467.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAMC01028797 Genomic DNA. No translation available.
    AAMC01028798 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali F6V515.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000012027 ; ENSXETP00000012027 ; ENSXETG00000005467 .

    Phylogenomic databases

    GeneTreei ENSGT00550000074874.
    OMAi CEAQLCY.
    OrthoDBi EOG771270.
    TreeFami TF312883.

    Enzyme and pathway databases

    UniPathwayi UPA00904 ; UER00873 .
    Reactomei REACT_225119. Methionine salvage pathway.

    Gene expression databases

    Bgeei F6V515.

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01963. MTAP.
    InterProi IPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01694. MTAP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiMTAP_XENTR
    AccessioniPrimary (citable) accession number: F6V515
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3