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F6V515

- MTAP_XENTR

UniProt

F6V515 - MTAP_XENTR

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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtap

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151PhosphateUniRule annotation
Sitei176 – 1761Important for substrate specificityUniRule annotation
Binding sitei194 – 1941Substrate; via amide nitrogenUniRule annotation
Binding sitei195 – 1951PhosphateUniRule annotation
Sitei231 – 2311Important for substrate specificityUniRule annotation

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

ReactomeiREACT_225119. Methionine salvage pathway.
UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Short name:
MTAPaseUniRule annotation
Gene namesi
Name:mtap
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Subcellular locationi

Cytoplasm UniRule annotation. Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281S-methyl-5'-thioadenosine phosphorylasePRO_0000415115Add
BLAST

Expressioni

Gene expression databases

BgeeiF6V515.
ExpressionAtlasiF6V515. baseline.

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF6V515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 592Phosphate bindingUniRule annotation
Regioni91 – 922Phosphate bindingUniRule annotation
Regioni218 – 2203Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074874.
InParanoidiF6V515.
OMAiCEAQLCY.
OrthoDBiEOG771270.
TreeFamiTF312883.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.

Sequencei

Sequence statusi: Complete.

F6V515 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGVCAVKVG IIGGSGLDDP DILEGRLEKY VDTPFGKPSD ALVLGKIKNV
60 70 80 90 100
DCVLLASRHG RQHTIAPTNV NYRANIWALK SEGCTHILVT TACGSLREEI
110 120 130 140 150
QPGDIVIVDQ FIDRTTKREQ TFYDGGPSCL PGVCHIPMAE PFCAKTREVL
160 170 180 190 200
IDIAKRLGIK CHSKGAMITI EGPRFSSKAE SQMFRLWGAD VINMTTVPEV
210 220 230 240 250
ILAKEAGICY ASIAMATDYD CWKEHEEAVS VDRVLKTLKE NANKATSILL
260 270 280
TAIPQIAAMD WTELLQSMKS TVQLSVMLPK H
Length:281
Mass (Da):30,699
Last modified:July 27, 2011 - v1
Checksum:i096C64113C943764
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAMC01028797 Genomic DNA. No translation available.
AAMC01028798 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSXETT00000012027; ENSXETP00000012027; ENSXETG00000005467.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAMC01028797 Genomic DNA. No translation available.
AAMC01028798 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F6V515.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000012027 ; ENSXETP00000012027 ; ENSXETG00000005467 .

Phylogenomic databases

GeneTreei ENSGT00550000074874.
InParanoidi F6V515.
OMAi CEAQLCY.
OrthoDBi EOG771270.
TreeFami TF312883.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .
Reactomei REACT_225119. Methionine salvage pathway.

Gene expression databases

Bgeei F6V515.
ExpressionAtlasi F6V515. baseline.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMTAP_XENTR
AccessioniPrimary (citable) accession number: F6V515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3