ID   F6UJC5_HUMAN            Unreviewed;       245 AA.
AC   F6UJC5;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   SubName: Full=DExD-box helicase 39B {ECO:0000313|Ensembl:ENSP00000408000.1};
DE   SubName: Full=Spliceosome RNA helicase DDX39B {ECO:0000313|Ensembl:ENSP00000393172.1};
DE   Flags: Fragment;
GN   Name=DDX39B {ECO:0000313|Ensembl:ENSP00000408000.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000408000.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000408000.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0007829|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [3] {ECO:0007829|PubMed:20068231}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [4] {ECO:0007829|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [5] {ECO:0007829|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [6] {ECO:0007829|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [7] {ECO:0000313|Ensembl:ENSP00000408000.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AL662801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL662847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX001040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX248516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX927320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR753820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR753864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR753892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR942185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteomicsDB; 28030; -.
DR   Antibodypedia; 27068; 450 antibodies from 29 providers.
DR   Ensembl; ENST00000415390.5; ENSP00000393172.1; ENSG00000230624.10.
DR   Ensembl; ENST00000427425.5; ENSP00000412286.1; ENSG00000225073.10.
DR   Ensembl; ENST00000427489.5; ENSP00000410915.1; ENSG00000235439.10.
DR   Ensembl; ENST00000431908.5; ENSP00000408000.1; ENSG00000198563.14.
DR   Ensembl; ENST00000446328.5; ENSP00000414096.1; ENSG00000215425.11.
DR   Ensembl; ENST00000448000.5; ENSP00000411967.1; ENSG00000225859.10.
DR   Ensembl; ENST00000452792.5; ENSP00000398978.1; ENSG00000229496.10.
DR   UCSC; uc063nba.1; human.
DR   HGNC; HGNC:13917; DDX39B.
DR   VEuPathDB; HostDB:ENSG00000198563; -.
DR   GeneTree; ENSGT00940000160110; -.
DR   HOGENOM; CLU_099289_0_0_1; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000198563; Expressed in granulocyte and 179 other cell types or tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR   PANTHER; PTHR47958:SF124; SPLICEOSOME RNA HELICASE DDX39B; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:F6UJC5,
KW   ECO:0007829|MaxQB:F6UJC5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          55..171
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   NON_TER         245
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000408000.1"
SQ   SEQUENCE   245 AA;  28300 MW;  9EA8162194217844 CRC64;
     MWTMSSWTMK MMRWRQQLGE MGLRPLPRRM SRAPMSPSTA LAFVTSCSSQ SCSGPLSTVA
     LSIRQKVAVF FGGLSIKKDE EVLKKNCPHI VVGTPGRILA LARNKSLNLK HIKHFILDEC
     DKMLEQLDMR RDVQEIFRMT PHEKQVMMFS ATLSKEIRPV CRKFMQDPME IFVDDETKLT
     LHGLQQYYVK LKDNEKNRKL FDLLDVLEFN QVVIFVKSVQ RCIALAQLLV EQNFPAIAIH
     RGMPQ
//