ID   F6UFK6_HUMAN            Unreviewed;       278 AA.
AC   F6UFK6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   SubName: Full=CD6 molecule {ECO:0000313|Ensembl:ENSP00000440055.1};
DE   Flags: Fragment;
GN   Name=CD6 {ECO:0000313|Ensembl:ENSP00000440055.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000440055.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000440055.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000440055.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR   EMBL; AP003721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F6UFK6; -.
DR   SMR; F6UFK6; -.
DR   MassIVE; F6UFK6; -.
DR   PeptideAtlas; F6UFK6; -.
DR   ProteomicsDB; 28020; -.
DR   Antibodypedia; 3732; 1398 antibodies from 45 providers.
DR   Ensembl; ENST00000542157.5; ENSP00000440055.1; ENSG00000013725.14.
DR   UCSC; uc058bxd.1; human.
DR   HGNC; HGNC:1691; CD6.
DR   VEuPathDB; HostDB:ENSG00000013725; -.
DR   GeneTree; ENSGT00940000161029; -.
DR   HOGENOM; CLU_026713_0_0_1; -.
DR   ChiTaRS; CD6; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000013725; Expressed in granulocyte and 175 other cell types or tissues.
DR   ExpressionAtlas; F6UFK6; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   Gene3D; 3.10.250.10; SRCR-like domain; 2.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR48071:SF22; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00530; SRCR; 2.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00202; SR; 2.
DR   SUPFAM; SSF56487; SRCR-like; 2.
DR   PROSITE; PS00420; SRCR_1; 1.
DR   PROSITE; PS50287; SRCR_2; 2.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00196};
KW   Proteomics identification {ECO:0007829|MaxQB:F6UFK6,
KW   ECO:0007829|PeptideAtlas:F6UFK6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..278
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003343943"
FT   DOMAIN          45..156
FT                   /note="SRCR"
FT                   /evidence="ECO:0000259|PROSITE:PS50287"
FT   DOMAIN          161..260
FT                   /note="SRCR"
FT                   /evidence="ECO:0000259|PROSITE:PS50287"
FT   REGION          18..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        230..240
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT   NON_TER         278
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000440055.1"
SQ   SEQUENCE   278 AA;  29193 MW;  C88B28B75164C7E7 CRC64;
     MWLFFGITGL LTAALSGHPS PAPPDQLNTS SAESELWEPG ERLPVRLTNG SSSCSGTVEV
     RLEASWEPAC GALWDSRAAE AVCRALGCGG AEAASQLAPP TPELPPPPAA GNTSVAANAT
     LAGAPALLCS GAEWRLCEVV EHACRSDGRR ARVTCAENRA LRLVDGGGAC AGRVEMLEHG
     EWGSVCDDTW DLEDAHVVCR QLGCGWAVQA LPGLHFTPGR GPIHRDQVNC SGAEAYLWDC
     PGLPGQHYCG HKEDAGAVCS ESSVTVKIEN KESRELML
//