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F6TVK6

- F6TVK6_MONDO

UniProt

F6TVK6 - F6TVK6_MONDO

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Protein
Submitted name: Uncharacterized protein
Gene
AXIN2
Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. signal transducer activity Source: InterPro

GO - Biological processi

  1. bone mineralization Source: Ensembl
  2. cell proliferation Source: Ensembl
  3. cellular protein localization Source: Ensembl
  4. chondrocyte differentiation involved in endochondral bone morphogenesis Source: Ensembl
  5. intramembranous ossification Source: Ensembl
  6. mRNA stabilization Source: Ensembl
  7. maintenance of DNA repeat elements Source: Ensembl
  8. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  9. negative regulation of catenin import into nucleus Source: Ensembl
  10. negative regulation of cell proliferation Source: Ensembl
  11. negative regulation of osteoblast differentiation Source: Ensembl
  12. odontogenesis Source: Ensembl
  13. positive regulation of cell death Source: Ensembl
  14. positive regulation of epithelial to mesenchymal transition Source: Ensembl
  15. positive regulation of protein phosphorylation Source: Ensembl
  16. regulation of centromeric sister chromatid cohesion Source: Ensembl
  17. regulation of chondrocyte development Source: Ensembl
  18. regulation of mismatch repair Source: Ensembl
  19. somitogenesis Source: Ensembl
  20. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:AXIN2Imported
OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
Taxonomic identifieri13616 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
ProteomesiUP000002280: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nucleus Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Contains 1 RGS domain.UniRule annotation
Contains RGS domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00390000010011.
OMAiKHVHHHY.
OrthoDBiEOG79PJQ0.
TreeFamiTF315454.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6TVK6-1 [UniParc]FASTAAdd to Basket

« Hide

MSSAVLVTHI SDPSSSFRED APRPPVPGEE GETPSCQQSA HLGQGKSLVT    50
KAMPISSNTR RNEDGLGEPE GRASPDSPLA RWTKSLHSLL GDQDGAYLFR 100
TFLEREQCVD TLDFWFACNG FRQMNLKDTK TLRVAKAIYK RYIENNCIVS 150
KQLKPATKTY IRDSIKKQQI DSIMFDQAQT EIQTVMEENA YQMFLTSDIY 200
LEYVRSGGEN PAYINNSGLG SLKVVCGYLP TLNEEEEWSC EDFKGKILPT 250
VVGLSSKTLR ATANVRSTEA VENGYRSFKR NDPVNPYHVS SGHVFAPAAS 300
ANDSEISSDA LTDDSMSMTD SSVDGIPPYR MGSKKQLQRE MHRSVKANGQ 350
VSLPHFPRTH RLPKEMTPIE PAIFAAELIS RLEKLKQEQE SLDNLEERLQ 400
QIKEDEEKEG LELIPVNTRE LALQHPLSLL PYGSYEEDPQ AILDDHLSRV 450
LKTPGCQSPG MGRHSPRSHS PDHHHHYRPL LQPGGRLPPP AASSALCPLG 500
KSFVTKQMTK HVYHHYIHHH TIPKTKEQIE VEAAQKVQCF CLGGTDYYLC 550
SKCKNHSKGV ELGPVEQFGR GNTLSKRNGK VTEPCLALSA KDGGVLVGTG 600
LLQLPGSEGD RSQNVWQWML ENERQNKHKP HSVQNTKKAY PLESTRGTIT 650
DRPARPHLWG GNMGHSRAMP HAHPFTQDSG MASLGPPNTL AQLEEACRRL 700
AEVSKPPKQR CCPSNQQKER NHSVGHLGGV SFCNPNLASE DHREPKKLAS 750
VHSLQASELV VTYFFCGEEI PYRRMLKAQS LTLGHFKEQL SKKGNYRYYF 800
KKASDEFDCG AVFEEIWEDD TILPMYEGRI LGKVERID 838
Length:838
Mass (Da):93,848
Last modified:January 9, 2013 - v2
Checksum:iCA1EDC4E6B582D1A
GO

Sequence databases

RefSeqiXP_007482823.1. XM_007482761.1.
UniGeneiMdm.5180.

Genome annotation databases

EnsembliENSMODT00000005364; ENSMODP00000005251; ENSMODG00000004260.
GeneIDi100024610.

Cross-referencesi

Sequence databases

RefSeqi XP_007482823.1. XM_007482761.1.
UniGenei Mdm.5180.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMODT00000005364 ; ENSMODP00000005251 ; ENSMODG00000004260 .
GeneIDi 100024610.

Phylogenomic databases

GeneTreei ENSGT00390000010011.
OMAi KHVHHHY.
OrthoDBi EOG79PJQ0.
TreeFami TF315454.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences."
    Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.
    , Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., Samollow P.B., Lander E.S., Lindblad-Toh K.
    Nature 447:167-177(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF6TVK6_MONDO
AccessioniPrimary (citable) accession number: F6TVK6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: January 9, 2013
Last modified: July 9, 2014
This is version 24 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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