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F6TVK6

- F6TVK6_MONDO

UniProt

F6TVK6 - F6TVK6_MONDO

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Protein
Submitted name:

Uncharacterized protein

Gene

AXIN2

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Biological processi

  1. bone mineralization Source: Ensembl
  2. cell proliferation Source: Ensembl
  3. cellular protein localization Source: Ensembl
  4. chondrocyte differentiation involved in endochondral bone morphogenesis Source: Ensembl
  5. intramembranous ossification Source: Ensembl
  6. maintenance of DNA repeat elements Source: Ensembl
  7. mRNA stabilization Source: Ensembl
  8. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  9. negative regulation of catenin import into nucleus Source: Ensembl
  10. negative regulation of cell proliferation Source: Ensembl
  11. negative regulation of osteoblast differentiation Source: Ensembl
  12. odontogenesis Source: Ensembl
  13. positive regulation of cell death Source: Ensembl
  14. positive regulation of epithelial to mesenchymal transition Source: Ensembl
  15. positive regulation of protein phosphorylation Source: Ensembl
  16. regulation of chondrocyte development Source: Ensembl
  17. regulation of mismatch repair Source: Ensembl
  18. secondary heart field specification Source: Ensembl
  19. somitogenesis Source: Ensembl
  20. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:AXIN2Imported
OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
Taxonomic identifieri13616 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
ProteomesiUP000002280: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiF6TVK6. baseline.

Family & Domainsi

Sequence similaritiesi

Contains 1 RGS domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000010011.
InParanoidiF6TVK6.
OMAiKHVHHHY.
OrthoDBiEOG79PJQ0.
TreeFamiTF315454.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6TVK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSAVLVTHI SDPSSSFRED APRPPVPGEE GETPSCQQSA HLGQGKSLVT
60 70 80 90 100
KAMPISSNTR RNEDGLGEPE GRASPDSPLA RWTKSLHSLL GDQDGAYLFR
110 120 130 140 150
TFLEREQCVD TLDFWFACNG FRQMNLKDTK TLRVAKAIYK RYIENNCIVS
160 170 180 190 200
KQLKPATKTY IRDSIKKQQI DSIMFDQAQT EIQTVMEENA YQMFLTSDIY
210 220 230 240 250
LEYVRSGGEN PAYINNSGLG SLKVVCGYLP TLNEEEEWSC EDFKGKILPT
260 270 280 290 300
VVGLSSKTLR ATANVRSTEA VENGYRSFKR NDPVNPYHVS SGHVFAPAAS
310 320 330 340 350
ANDSEISSDA LTDDSMSMTD SSVDGIPPYR MGSKKQLQRE MHRSVKANGQ
360 370 380 390 400
VSLPHFPRTH RLPKEMTPIE PAIFAAELIS RLEKLKQEQE SLDNLEERLQ
410 420 430 440 450
QIKEDEEKEG LELIPVNTRE LALQHPLSLL PYGSYEEDPQ AILDDHLSRV
460 470 480 490 500
LKTPGCQSPG MGRHSPRSHS PDHHHHYRPL LQPGGRLPPP AASSALCPLG
510 520 530 540 550
KSFVTKQMTK HVYHHYIHHH TIPKTKEQIE VEAAQKVQCF CLGGTDYYLC
560 570 580 590 600
SKCKNHSKGV ELGPVEQFGR GNTLSKRNGK VTEPCLALSA KDGGVLVGTG
610 620 630 640 650
LLQLPGSEGD RSQNVWQWML ENERQNKHKP HSVQNTKKAY PLESTRGTIT
660 670 680 690 700
DRPARPHLWG GNMGHSRAMP HAHPFTQDSG MASLGPPNTL AQLEEACRRL
710 720 730 740 750
AEVSKPPKQR CCPSNQQKER NHSVGHLGGV SFCNPNLASE DHREPKKLAS
760 770 780 790 800
VHSLQASELV VTYFFCGEEI PYRRMLKAQS LTLGHFKEQL SKKGNYRYYF
810 820 830
KKASDEFDCG AVFEEIWEDD TILPMYEGRI LGKVERID
Length:838
Mass (Da):93,848
Last modified:January 9, 2013 - v2
Checksum:iCA1EDC4E6B582D1A
GO

Sequence databases

RefSeqiXP_007482823.1. XM_007482761.1.
UniGeneiMdm.5180.

Genome annotation databases

EnsembliENSMODT00000005364; ENSMODP00000005251; ENSMODG00000004260.
GeneIDi100024610.

Cross-referencesi

Sequence databases

RefSeqi XP_007482823.1. XM_007482761.1.
UniGenei Mdm.5180.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMODT00000005364 ; ENSMODP00000005251 ; ENSMODG00000004260 .
GeneIDi 100024610.

Organism-specific databases

CTDi 8313.

Phylogenomic databases

GeneTreei ENSGT00390000010011.
InParanoidi F6TVK6.
OMAi KHVHHHY.
OrthoDBi EOG79PJQ0.
TreeFami TF315454.

Gene expression databases

ExpressionAtlasi F6TVK6. baseline.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences."
    Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.
    , Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., Samollow P.B., Lander E.S., Lindblad-Toh K.
    Nature 447:167-177(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF6TVK6_MONDO
AccessioniPrimary (citable) accession number: F6TVK6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: January 9, 2013
Last modified: October 29, 2014
This is version 26 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3