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F6TVK6

- F6TVK6_MONDO

UniProt

F6TVK6 - F6TVK6_MONDO

Protein
Submitted name:

Uncharacterized protein

Gene

AXIN2

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 2 (09 Jan 2013)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. signal transducer activity Source: InterPro

    GO - Biological processi

    1. bone mineralization Source: Ensembl
    2. cell proliferation Source: Ensembl
    3. cellular protein localization Source: Ensembl
    4. chondrocyte differentiation involved in endochondral bone morphogenesis Source: Ensembl
    5. intramembranous ossification Source: Ensembl
    6. maintenance of DNA repeat elements Source: Ensembl
    7. mRNA stabilization Source: Ensembl
    8. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    9. negative regulation of catenin import into nucleus Source: Ensembl
    10. negative regulation of cell proliferation Source: Ensembl
    11. negative regulation of osteoblast differentiation Source: Ensembl
    12. odontogenesis Source: Ensembl
    13. positive regulation of cell death Source: Ensembl
    14. positive regulation of epithelial to mesenchymal transition Source: Ensembl
    15. positive regulation of protein phosphorylation Source: Ensembl
    16. regulation of centromeric sister chromatid cohesion Source: Ensembl
    17. regulation of chondrocyte development Source: Ensembl
    18. regulation of mismatch repair Source: Ensembl
    19. somitogenesis Source: Ensembl
    20. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:AXIN2Imported
    OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
    Taxonomic identifieri13616 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
    ProteomesiUP000002280: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. nucleus Source: Ensembl

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 RGS domain.UniRule annotation
    Contains RGS domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000010011.
    OMAiKHVHHHY.
    OrthoDBiEOG79PJQ0.
    TreeFamiTF315454.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00021. DAX. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6TVK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAVLVTHI SDPSSSFRED APRPPVPGEE GETPSCQQSA HLGQGKSLVT    50
    KAMPISSNTR RNEDGLGEPE GRASPDSPLA RWTKSLHSLL GDQDGAYLFR 100
    TFLEREQCVD TLDFWFACNG FRQMNLKDTK TLRVAKAIYK RYIENNCIVS 150
    KQLKPATKTY IRDSIKKQQI DSIMFDQAQT EIQTVMEENA YQMFLTSDIY 200
    LEYVRSGGEN PAYINNSGLG SLKVVCGYLP TLNEEEEWSC EDFKGKILPT 250
    VVGLSSKTLR ATANVRSTEA VENGYRSFKR NDPVNPYHVS SGHVFAPAAS 300
    ANDSEISSDA LTDDSMSMTD SSVDGIPPYR MGSKKQLQRE MHRSVKANGQ 350
    VSLPHFPRTH RLPKEMTPIE PAIFAAELIS RLEKLKQEQE SLDNLEERLQ 400
    QIKEDEEKEG LELIPVNTRE LALQHPLSLL PYGSYEEDPQ AILDDHLSRV 450
    LKTPGCQSPG MGRHSPRSHS PDHHHHYRPL LQPGGRLPPP AASSALCPLG 500
    KSFVTKQMTK HVYHHYIHHH TIPKTKEQIE VEAAQKVQCF CLGGTDYYLC 550
    SKCKNHSKGV ELGPVEQFGR GNTLSKRNGK VTEPCLALSA KDGGVLVGTG 600
    LLQLPGSEGD RSQNVWQWML ENERQNKHKP HSVQNTKKAY PLESTRGTIT 650
    DRPARPHLWG GNMGHSRAMP HAHPFTQDSG MASLGPPNTL AQLEEACRRL 700
    AEVSKPPKQR CCPSNQQKER NHSVGHLGGV SFCNPNLASE DHREPKKLAS 750
    VHSLQASELV VTYFFCGEEI PYRRMLKAQS LTLGHFKEQL SKKGNYRYYF 800
    KKASDEFDCG AVFEEIWEDD TILPMYEGRI LGKVERID 838
    Length:838
    Mass (Da):93,848
    Last modified:January 9, 2013 - v2
    Checksum:iCA1EDC4E6B582D1A
    GO

    Sequence databases

    RefSeqiXP_007482823.1. XM_007482761.1.
    UniGeneiMdm.5180.

    Genome annotation databases

    EnsembliENSMODT00000005364; ENSMODP00000005251; ENSMODG00000004260.
    GeneIDi100024610.

    Cross-referencesi

    Sequence databases

    RefSeqi XP_007482823.1. XM_007482761.1.
    UniGenei Mdm.5180.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMODT00000005364 ; ENSMODP00000005251 ; ENSMODG00000004260 .
    GeneIDi 100024610.

    Phylogenomic databases

    GeneTreei ENSGT00390000010011.
    OMAi KHVHHHY.
    OrthoDBi EOG79PJQ0.
    TreeFami TF315454.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00021. DAX. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences."
      Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.
      , Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., Samollow P.B., Lander E.S., Lindblad-Toh K.
      Nature 447:167-177(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiF6TVK6_MONDO
    AccessioniPrimary (citable) accession number: F6TVK6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: January 9, 2013
    Last modified: October 1, 2014
    This is version 25 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3