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Protein

U6 snRNA phosphodiesterase

Gene

USB1

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei120Proton donor/acceptorUniRule annotation1
Active sitei208Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, NucleaseUniRule annotation
Biological processmRNA processing, mRNA splicingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA phosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:USB1UniRule annotationImported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Chromosome 20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi9483.ENSCJAP00000021571.

Family & Domainsi

Sequence similaritiesi

Belongs to the 2H phosphoesterase superfamily. USB1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3102. Eukaryota.
ENOG4111KT5. LUCA.
GeneTreeiENSGT00390000004596.
OMAiTFYKDPS.
OrthoDBiEOG091G0HOU.
TreeFamiTF324364.

Family and domain databases

HAMAPiMF_03040. USB1. 1 hit.
InterProiView protein in InterPro
IPR009097. cNuc_Pdiesterase.
IPR027521. Usb1.
PANTHERiPTHR13522. PTHR13522. 1 hit.
PfamiView protein in Pfam
PF09749. HVSL. 1 hit.
SUPFAMiSSF55144. SSF55144. 1 hit.

Sequencei

Sequence statusi: Complete.

F6TF64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAPLVGYS SSGSEDESED GMRTRPGDGS QRSGQSPLPR QRFPVPDSVL
60 70 80 90 100
NMFPGTEEGP EDDSAKHGGR VRTFPHERGN WATHVYIPYE AKEEFLDLLD
110 120 130 140 150
VLLPHAQTYV PRLVRMEAFH LSLSQSVVLR HHWILPFVQA LKARVASFQR
160 170 180 190 200
FFFTANQVKI YTNQEKTRTF IGLEVTSGHA QFLDLVSEVD RVMEEFDLTT
210 220 230 240 250
FYQDPSFHLS LAWCVGDARL QLEGQCLQEL QAIVDGFEDA EVLLRMHTEQ
260
VRCKSGNKFF SMPLK
Length:265
Mass (Da):30,109
Last modified:July 27, 2011 - v1
Checksum:iD4C6620994AED122
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFV01100085 Genomic DNA. No translation available.
GAMT01009349 mRNA. Translation: JAB02512.1.
GAMS01010386 mRNA. Translation: JAB12750.1.
GAMR01010776 mRNA. Translation: JAB23156.1.
GAMQ01000183 mRNA. Translation: JAB41668.1.
GAMP01008688 mRNA. Translation: JAB44067.1.
RefSeqiXP_002761061.1. XM_002761015.3.

Genome annotation databases

EnsembliENSCJAT00000022803; ENSCJAP00000021571; ENSCJAG00000011733.
GeneIDi100386861.
KEGGicjc:100386861.

Similar proteinsi

Entry informationi

Entry nameiF6TF64_CALJA
AccessioniPrimary (citable) accession number: F6TF64
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: September 27, 2017
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported