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Protein
Submitted name:

Uncharacterized protein

Gene

ITGA8

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

  1. cell-matrix adhesion Source: Ensembl
  2. cell projection organization Source: Ensembl
  3. establishment of protein localization Source: Ensembl
  4. extracellular matrix organization Source: Ensembl
  5. inner ear morphogenesis Source: Ensembl
  6. integrin-mediated signaling pathway Source: UniProtKB-KW
  7. memory Source: Ensembl
  8. mesodermal cell differentiation Source: Ensembl
  9. metanephros development Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: Ensembl
  11. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  12. smooth muscle tissue development Source: Ensembl
  13. substrate adhesion-dependent cell spreading Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation

Keywords - Biological processi

Cell adhesionUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:ITGA8Imported
OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
Taxonomic identifieri13616 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
ProteomesiUP000002280 Componenti: Chromosome 8

Subcellular locationi

  1. Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. cell surface Source: Ensembl
  3. endoplasmic reticulum Source: Ensembl
  4. focal adhesion Source: Ensembl
  5. integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotation
Contains FG-GAP repeats.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118782.
InParanoidiF6TCV7.
KOiK06584.
OMAiQNFTGEQ.
OrthoDBiEOG7HQN77.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 6 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6TCV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGGPRCPA VGSREQLRAP LWGFWTALGM LCSPVSQAFN LDVDKLTVYS
60 70 80 90 100
GPEGSYFGYA VDFHIPDQRT VSILVGAPKA NTSQPDIVEG GAVYYCPWPA
110 120 130 140 150
TGDVHCKQIP FDTTNNRKIR VNGTKEPIEF KSNQWFGATV KAHKGKVVAC
160 170 180 190 200
APLYHWRTLK ATREKDPVGT CYVAIQNFSA YAEYSPCRNS NADPEGQGYC
210 220 230 240 250
QAGFSLDFYK NGDLIVGGPG SFYWQGQVIT ANIADIIANY SFKDILRKLT
260 270 280 290 300
REKQTEVAPA SYDDSYLGYS VAAGEFTGDS QQEILAGVPR GAQNFGYVSI
310 320 330 340 350
INSTDMTFIQ NFTGEQMASY FGYALSVSDV NNDGLDDVLV GAPLFMEREF
360 370 380 390 400
ESSPKEVGQV YLYLQESPLL FRDAQVLSGT EVFGRFGSAI THLGDLNQDG
410 420 430 440 450
YNDIAVGAPF AGEAGRGKVF IYNGNAEGLN QKPSQILNGA WASQAVPSGF
460 470 480 490 500
GFTLRGDSDI DKNDYPDLIV GAFGTGKVVV YRARPVVTVD AQLLLHPMII
510 520 530 540 550
NLENKTCQIP SLATLVPCFT LRVCASVEGQ SISNTVGLIA DVQLDSLKQK
560 570 580 590 600
GAIKRTLFRD NHQSQFVFPL VINQYQSLQC QDFIIYLRDE TEFRDKLSPI
610 620 630 640 650
NISLNYSLDE STFEEGLAVK PILNFYRESI VNEQAHILVD CGDDNMCIPD
660 670 680 690 700
LKLSAVPDKE QLIIGDENHL MLIINARNGG EGAYEAELFV LIPEEADYVG
710 720 730 740 750
IERNNKALHP LSCEYKMDNV TRMVVCDLGN PMAAGTNYSL GLRFAVTHLE
760 770 780 790 800
NTNTSIDFDL QIRSSNKDNP DSNSVSLKIN VTAVAQVEIR GVSHPPQIVL
810 820 830 840 850
PIHNWEPEEE PHKEEEVGPL VEHIYELHNI GPSTISETLL TVGWPNSARE
860 870 880 890 900
EFLLYIFHIQ TLGPLQCQTN PAINSLGIKP AASQEDTPAL SAFLRNSSIP
910 920 930 940 950
HIVRKRHVPV VELHRQSPAK ILNCTNIECL RISCVVGRLE GGESAVLKVR
960 970 980 990 1000
SRLWAQTFLQ RKNDPYSLAS IVSFEVKKMP YNEQPAQLPK GNVAIRTSVI
1010 1020 1030 1040 1050
WATPNVSFSI PLWVIILAIL LGLLVLTLLT LALWKCGFFD RARPPQDDMA
1060
DREQLTNDKV PDA
Length:1,063
Mass (Da):117,296
Last modified:July 27, 2011 - v1
Checksum:iCD935BF3C52C083C
GO

Sequence databases

RefSeqiXP_001377488.1. XM_001377451.2.

Genome annotation databases

EnsembliENSMODT00000012824; ENSMODP00000012596; ENSMODG00000010054.
GeneIDi100027090.
KEGGimdo:100027090.

Cross-referencesi

Sequence databases

RefSeqiXP_001377488.1. XM_001377451.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMODT00000012824; ENSMODP00000012596; ENSMODG00000010054.
GeneIDi100027090.
KEGGimdo:100027090.

Organism-specific databases

CTDi8516.

Phylogenomic databases

GeneTreeiENSGT00760000118782.
InParanoidiF6TCV7.
KOiK06584.
OMAiQNFTGEQ.
OrthoDBiEOG7HQN77.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 6 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences."
    Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.
    , Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., Samollow P.B., Lander E.S., Lindblad-Toh K.
    Nature 447:167-177(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF6TCV7_MONDO
AccessioniPrimary (citable) accession number: F6TCV7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 4, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.