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F6TCV7

- F6TCV7_MONDO

UniProt

F6TCV7 - F6TCV7_MONDO

Protein
Submitted name:

Uncharacterized protein

Gene

ITGA8

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. cell projection organization Source: Ensembl
    3. establishment of protein localization Source: Ensembl
    4. extracellular matrix organization Source: Ensembl
    5. inner ear morphogenesis Source: Ensembl
    6. integrin-mediated signaling pathway Source: UniProtKB-KW
    7. memory Source: Ensembl
    8. metanephros development Source: Ensembl
    9. positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: Ensembl
    10. positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    11. smooth muscle tissue development Source: Ensembl

    Keywords - Molecular functioni

    IntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation

    Keywords - Biological processi

    Cell adhesionUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:ITGA8Imported
    OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
    Taxonomic identifieri13616 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
    ProteomesiUP000002280: Chromosome 8

    Subcellular locationi

    Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. integrin complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.UniRule annotation
    Contains FG-GAP repeats.SAAS annotation

    Keywords - Domaini

    RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117267.
    KOiK06584.
    OMAiCRQIPFD.
    OrthoDBiEOG7HQN77.
    TreeFamiTF105391.

    Family and domain databases

    InterProiIPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view]
    PfamiPF01839. FG-GAP. 2 hits.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 6 hits.
    [Graphical view]
    PROSITEiPS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6TCV7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQGGPRCPA VGSREQLRAP LWGFWTALGM LCSPVSQAFN LDVDKLTVYS     50
    GPEGSYFGYA VDFHIPDQRT VSILVGAPKA NTSQPDIVEG GAVYYCPWPA 100
    TGDVHCKQIP FDTTNNRKIR VNGTKEPIEF KSNQWFGATV KAHKGKVVAC 150
    APLYHWRTLK ATREKDPVGT CYVAIQNFSA YAEYSPCRNS NADPEGQGYC 200
    QAGFSLDFYK NGDLIVGGPG SFYWQGQVIT ANIADIIANY SFKDILRKLT 250
    REKQTEVAPA SYDDSYLGYS VAAGEFTGDS QQEILAGVPR GAQNFGYVSI 300
    INSTDMTFIQ NFTGEQMASY FGYALSVSDV NNDGLDDVLV GAPLFMEREF 350
    ESSPKEVGQV YLYLQESPLL FRDAQVLSGT EVFGRFGSAI THLGDLNQDG 400
    YNDIAVGAPF AGEAGRGKVF IYNGNAEGLN QKPSQILNGA WASQAVPSGF 450
    GFTLRGDSDI DKNDYPDLIV GAFGTGKVVV YRARPVVTVD AQLLLHPMII 500
    NLENKTCQIP SLATLVPCFT LRVCASVEGQ SISNTVGLIA DVQLDSLKQK 550
    GAIKRTLFRD NHQSQFVFPL VINQYQSLQC QDFIIYLRDE TEFRDKLSPI 600
    NISLNYSLDE STFEEGLAVK PILNFYRESI VNEQAHILVD CGDDNMCIPD 650
    LKLSAVPDKE QLIIGDENHL MLIINARNGG EGAYEAELFV LIPEEADYVG 700
    IERNNKALHP LSCEYKMDNV TRMVVCDLGN PMAAGTNYSL GLRFAVTHLE 750
    NTNTSIDFDL QIRSSNKDNP DSNSVSLKIN VTAVAQVEIR GVSHPPQIVL 800
    PIHNWEPEEE PHKEEEVGPL VEHIYELHNI GPSTISETLL TVGWPNSARE 850
    EFLLYIFHIQ TLGPLQCQTN PAINSLGIKP AASQEDTPAL SAFLRNSSIP 900
    HIVRKRHVPV VELHRQSPAK ILNCTNIECL RISCVVGRLE GGESAVLKVR 950
    SRLWAQTFLQ RKNDPYSLAS IVSFEVKKMP YNEQPAQLPK GNVAIRTSVI 1000
    WATPNVSFSI PLWVIILAIL LGLLVLTLLT LALWKCGFFD RARPPQDDMA 1050
    DREQLTNDKV PDA 1063
    Length:1,063
    Mass (Da):117,296
    Last modified:July 27, 2011 - v1
    Checksum:iCD935BF3C52C083C
    GO

    Sequence databases

    RefSeqiXP_001377488.1. XM_001377451.2.

    Genome annotation databases

    EnsembliENSMODT00000012824; ENSMODP00000012596; ENSMODG00000010054.
    GeneIDi100027090.
    KEGGimdo:100027090.

    Cross-referencesi

    Sequence databases

    RefSeqi XP_001377488.1. XM_001377451.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMODT00000012824 ; ENSMODP00000012596 ; ENSMODG00000010054 .
    GeneIDi 100027090.
    KEGGi mdo:100027090.

    Organism-specific databases

    CTDi 8516.

    Phylogenomic databases

    GeneTreei ENSGT00750000117267.
    KOi K06584.
    OMAi CRQIPFD.
    OrthoDBi EOG7HQN77.
    TreeFami TF105391.

    Family and domain databases

    InterProi IPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    [Graphical view ]
    Pfami PF01839. FG-GAP. 2 hits.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 6 hits.
    [Graphical view ]
    PROSITEi PS51470. FG_GAP. 7 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences."
      Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.
      , Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., Samollow P.B., Lander E.S., Lindblad-Toh K.
      Nature 447:167-177(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiF6TCV7_MONDO
    AccessioniPrimary (citable) accession number: F6TCV7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3