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Protein

Annexin

Gene

ANXA1

Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:ANXA1Imported
OrganismiOrnithorhynchus anatinus (Duckbill platypus)Imported
Taxonomic identifieri9258 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
Proteomesi
  • UP000002279 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSOANG00000013140.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9258.ENSOANP00000020763.

Family & Domainsi

Domaini

The full-length protein can bind eight Ca2+ ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca2+, these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
InParanoidiF6T207.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiView protein in InterPro
IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR037104. Annexin_sf.
IPR002388. ANX1.
PANTHERiPTHR10502:SF17. PTHR10502:SF17. 1 hit.
PfamiView protein in Pfam
PF00191. Annexin. 4 hits.
PRINTSiPR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTiView protein in SMART
SM00335. ANX. 4 hits.
PROSITEiView protein in PROSITE
PS00223. ANNEXIN. 3 hits.

Sequencei

Sequence statusi: Complete.

F6T207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLGVSETSV KMAMVSEFLK QAWFMDNEEQ EYIKTTKGSK GGHGSAVNTY
60 70 80 90 100
PNFNPSADAA ALDKAITAKG VDEATIIEIL TKRTNAQRQQ IKAAYQQAKG
110 120 130 140 150
KPLDEALKKV LKGQFEDVVL AMLKTPAQFD ADELRGAMKG LGTDEEALIE
160 170 180 190 200
ILASRTSQEI KAANRVYREE LKRDLAKDIT SDTSGDFQKA LLSLAKGDRS
210 220 230 240 250
EDPGVNDELA DNDARALYEA GEKRKGTDVN VFNTILTTRS YPHLRRVFQK
260 270 280 290 300
YAKYSQHDMN KVLDLELKGD IENCLTAIVK CATCKPAFFA EKLHLAMKGA
310 320 330 340 350
GTRHKTLIRI MVSRAEIDMN EIKVYYQKLY GVSLCQAILD ETKGDYETIL

VALCGGN
Length:357
Mass (Da):39,578
Last modified:January 9, 2013 - v2
Checksum:iAF867651CB6F6114
GO

Sequence databases

RefSeqiXP_007665210.1. XM_007667020.1.

Genome annotation databases

EnsembliENSOANT00000020766; ENSOANP00000020763; ENSOANG00000013140.
GeneIDi100073833.

Similar proteinsi

Entry informationi

Entry nameiF6T207_ORNAN
AccessioniPrimary (citable) accession number: F6T207
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: January 9, 2013
Last modified: October 25, 2017
This is version 50 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported