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F6SEU4

- SYGP1_MOUSE

UniProt

F6SEU4 - SYGP1_MOUSE

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Protein
Ras/Rap GTPase-activating protein SynGAP
Gene
Syngap1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits By similarity.

GO - Molecular functioni

  1. Rab GTPase activator activity Source: MGI
  2. protein binding Source: MGI

GO - Biological processi

  1. Ras protein signal transduction Source: MGI
  2. dendrite development Source: MGI
  3. negative regulation of Ras protein signal transduction Source: UniProtKB
  4. negative regulation of axonogenesis Source: MGI
  5. negative regulation of neuron apoptotic process Source: MGI
  6. pattern specification process Source: MGI
  7. positive regulation of Rab GTPase activity Source: GOC
  8. positive regulation of Ras GTPase activity Source: RefGenome
  9. receptor clustering Source: MGI
  10. regulation of MAPK cascade Source: MGI
  11. regulation of long-term neuronal synaptic plasticity Source: MGI
  12. regulation of synapse structure and activity Source: MGI
  13. regulation of synaptic plasticity Source: UniProtKB
  14. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras/Rap GTPase-activating protein SynGAP
Alternative name(s):
Neuronal RasGAP
Synaptic Ras GTPase-activating protein 1
Short name:
Synaptic Ras-GAP 1
Gene namesi
Name:Syngap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:3039785. Syngap1.

Subcellular locationi

Membrane; Peripheral membrane protein By similarity. Cell junctionsynapse By similarity
Note: Mostly in excitatory glutamatergic synapses By similarity. receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity By similarity.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasm Source: RefGenome
  3. dendritic shaft Source: MGI
  4. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome
  5. membrane Source: MGI
  6. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13401340Ras/Rap GTPase-activating protein SynGAP
PRO_0000414716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341Phosphotyrosine1 Publication
Modified residuei39 – 391Phosphotyrosine1 Publication
Modified residuei379 – 3791Phosphoserine; by PLK2 By similarity
Modified residuei385 – 3851Phosphoserine; by PLK2 By similarity
Modified residuei449 – 4491Phosphoserine; by PLK2 By similarity
Modified residuei466 – 4661Phosphoserine; by PLK2 By similarity
Modified residuei836 – 8361Phosphoserine; by PLK2 By similarity
Modified residuei840 – 8401Phosphoserine; by PLK2 By similarity
Modified residuei842 – 8421Phosphoserine; by PLK2 By similarity
Modified residuei895 – 8951Phosphoserine; by PLK2 By similarity
Modified residuei1201 – 12011Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiF6SEU4.

Expressioni

Gene expression databases

BgeeiF6SEU4.

Interactioni

Subunit structurei

Interacts KLHL17, CAMK2A and CAMK2B. Interacts with MPDZ By similarity.

Protein-protein interaction databases

IntActiF6SEU4. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliF6SEU4.
SMRiF6SEU4. Positions 401-734.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 251102PH
Add
BLAST
Domaini249 – 34799C2
Add
BLAST
Domaini443 – 635193Ras-GAP
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi785 – 81531SH3-binding Reviewed prediction
Add
BLAST

Domaini

The C2 domain is required for RapGAP activity By similarity.

Sequence similaritiesi

Contains 1 C2 domain.
Contains 1 PH domain.
Contains 1 Ras-GAP domain.

Keywords - Domaini

SH3-binding

Phylogenomic databases

GeneTreeiENSGT00600000084217.
KOiK17631.
OMAiNPHIQRQ.
OrthoDBiEOG74XS5P.
TreeFamiTF105303.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.20.170.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR021887. DUF3498.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR023315. SynGAP_C2_N.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF12004. DUF3498. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6SEU4-1 [UniParc]FASTAAdd to Basket

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MSRSRASIHR GSIPAMSYAP FRDVRGPPMH RTQYVHSPYD RPGWNPRFCI     50
ISGNQLLMLD EDEIHPLLIR DRRSESSRNK LLRRTVSVPV EGRPHGEHEY 100
HLGRSRRKSV PGGKQYSMEA APAAPFRPSQ GFLSRRLKSS IKRTKSQPKL 150
DRTSSFRQIL PRFRSADHDR ARLMQSFKES HSHESLLSPS SAAEALELNL 200
DEDSIIKPVH SSILGQEFCF EVTTSSGTKC FACRSAAERD KWIENLQRAV 250
KPNKDNSRRV DNVLKLWIIE ARELPPKKRY YCELCLDDML YARTTSKPRS 300
ASGDTVFWGE HFEFNNLPAV RALRLHLYRD SDKKRKKDKA GYVGLVTVPV 350
ATLAGRHFTE QWYPVTLPTG SGGSGGMGSG GGGGSGGGSG GKGKGGCPAV 400
RLKARYQTMS ILPMELYKEF AEYVTNHYRM LCAVLEPALN VKGKEEVASA 450
LVHILQSTGK AKDFLSDMAM SEVDRFMERE HLIFRENTLA TKAIEEYMRL 500
IGQKYLKDAI GEFIRALYES EENCEVDPIK CTASSLAEHQ ANLRMCCELA 550
LCKVVNSHCV FPRELKEVFA SWRLRCAERG REDIADRLIS ASLFLRFLCP 600
AIMSPSLFGL MQEYPDEQTS RTLTLIAKVI QNLANFSKFT SKEDFLGFMN 650
EFLELEWGSM QQFLYEISNL DTLTNSSSFE GYIDLGRELS TLHALLWEVL 700
PQLSKEALLK LGPLPRLLND ISTALRNPNI QRQPSRQSER TRSQPMVLRG 750
PSAEMQGYMM RDLNSSIDLQ SFMARGLNSS MDMARLPSPT KEKPPPPPPG 800
GGKDLFYVSR PPLARSSPAY CTSSSDITEP EQKMLSVNKS VSMLDLQGDG 850
PGGRLNSSSV SNLAAVGDLL HSSQASLTAA LGLRPAPAGR LSQGSGSSIT 900
AAGMRLSQMG VTTDGVPAQQ LRIPLSFQNP LFHMAADGPG PPAGHGGSSG 950
HGPPSSHHHH HHHHHHRGGE PPGDTFAPFH GYSKSEDLSS GVPKPPAASI 1000
LHSHSYSDEF GPSGTDFTRR QLSLQDSLQH MLSPPQITIG PQRPAPSGPG 1050
GGSGGGSGGG QPPPLQRGKS QQLTVSAAQK PRPSSGNLLQ SPEPSYGPAR 1100
PRQQSLSKEG SIGGSGGSGG GGGGGLKPSI TKQHSQTPST LNPTMPASER 1150
TVAWVSNMPH LSADIESAHI EREEYKLKEY SKSMDESRLD RVKEYEEEIH 1200
SLKERLHMSN RKLEEYERRL LSQEEQTSKI LMQYQARLEQ SEKRLRQQQV 1250
EKDSQIKSII GRLMLVEEEL RRDHPAMAEP LPEPKKRLLD AQERQLPPLG 1300
PTNPRVTLAP PWNGLAPPAP PPPPRLQITE NGEFRNTADH 1340
Length:1,340
Mass (Da):148,238
Last modified:December 14, 2011 - v2
Checksum:i4D2E4FB4F33E63D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC144621 Genomic DNA. No translation available.
CCDSiCCDS59625.1.
RefSeqiNP_001268420.1. NM_001281491.1.
UniGeneiMm.328888.

Genome annotation databases

EnsembliENSMUST00000081285; ENSMUSP00000080038; ENSMUSG00000067629.
GeneIDi240057.
KEGGimmu:240057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC144621 Genomic DNA. No translation available.
CCDSi CCDS59625.1.
RefSeqi NP_001268420.1. NM_001281491.1.
UniGenei Mm.328888.

3D structure databases

ProteinModelPortali F6SEU4.
SMRi F6SEU4. Positions 401-734.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi F6SEU4. 2 interactions.

Proteomic databases

PRIDEi F6SEU4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000081285 ; ENSMUSP00000080038 ; ENSMUSG00000067629 .
GeneIDi 240057.
KEGGi mmu:240057.

Organism-specific databases

CTDi 8831.
MGIi MGI:3039785. Syngap1.

Phylogenomic databases

GeneTreei ENSGT00600000084217.
KOi K17631.
OMAi NPHIQRQ.
OrthoDBi EOG74XS5P.
TreeFami TF105303.

Miscellaneous databases

NextBioi 384399.
PROi F6SEU4.
SOURCEi Search...

Gene expression databases

Bgeei F6SEU4.

Family and domain databases

Gene3Di 1.10.506.10. 1 hit.
2.20.170.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
IPR021887. DUF3498.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR023315. SynGAP_C2_N.
[Graphical view ]
Pfami PF00168. C2. 1 hit.
PF12004. DUF3498. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view ]
SMARTi SM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1201, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  3. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-34 AND TYR-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiSYGP1_MOUSE
AccessioniPrimary (citable) accession number: F6SEU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: December 14, 2011
Last modified: September 3, 2014
This is version 30 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi