Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras/Rap GTPase-activating protein SynGAP

Gene

Syngap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).By similarity

GO - Molecular functioni

  • GTPase activator activity Source: MGI

GO - Biological processi

  • dendrite development Source: MGI
  • negative regulation of axonogenesis Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of Ras protein signal transduction Source: UniProtKB
  • pattern specification process Source: MGI
  • Ras protein signal transduction Source: MGI
  • receptor clustering Source: MGI
  • regulation of long-term neuronal synaptic plasticity Source: MGI
  • regulation of MAPK cascade Source: MGI
  • regulation of synapse structure or activity Source: MGI
  • regulation of synaptic plasticity Source: UniProtKB
  • visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-5658442. Regulation of RAS by GAPs.
R-MMU-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras/Rap GTPase-activating protein SynGAP
Alternative name(s):
Neuronal RasGAP
Synaptic Ras GTPase-activating protein 1
Short name:
Synaptic Ras-GAP 1
Gene namesi
Name:Syngap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3039785. Syngap1.

Subcellular locationi

  • Membrane By similarity; Peripheral membrane protein By similarity
  • Cell junctionsynapse By similarity

  • Note: Mostly in excitatory glutamatergic synapses (By similarity). receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity (By similarity).By similarity

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: GO_Central
  • dendritic shaft Source: MGI
  • intrinsic component of the cytoplasmic side of the plasma membrane Source: GO_Central
  • membrane Source: MGI
  • postsynaptic density Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004147161 – 1340Ras/Rap GTPase-activating protein SynGAPAdd BLAST1340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphotyrosineCombined sources1
Modified residuei39PhosphotyrosineCombined sources1
Modified residuei117PhosphoserineBy similarity1
Modified residuei371PhosphoserineCombined sources1
Modified residuei379Phosphoserine; by PLK2By similarity1
Modified residuei385Phosphoserine; by PLK2By similarity1
Modified residuei449Phosphoserine; by PLK2By similarity1
Modified residuei466Phosphoserine; by PLK2By similarity1
Modified residuei752PhosphoserineBy similarity1
Modified residuei766PhosphoserineBy similarity1
Modified residuei780PhosphoserineBy similarity1
Modified residuei823PhosphoserineCombined sources1
Modified residuei825PhosphoserineCombined sources1
Modified residuei828PhosphothreonineCombined sources1
Modified residuei836Phosphoserine; by PLK2By similarity1
Modified residuei840Phosphoserine; by PLK2By similarity1
Modified residuei842Phosphoserine; by PLK2By similarity1
Modified residuei876PhosphoserineCombined sources1
Modified residuei892PhosphoserineBy similarity1
Modified residuei895PhosphoserineCombined sources1
Modified residuei898PhosphoserineCombined sources1
Modified residuei985PhosphoserineCombined sources1
Modified residuei1111PhosphoserineBy similarity1
Modified residuei1115PhosphoserineBy similarity1
Modified residuei1118PhosphoserineBy similarity1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1201PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiF6SEU4.
PaxDbiF6SEU4.
PeptideAtlasiF6SEU4.
PRIDEiF6SEU4.

PTM databases

iPTMnetiF6SEU4.
PhosphoSitePlusiF6SEU4.
SwissPalmiF6SEU4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000067629.
ExpressionAtlasiF6SEU4. baseline and differential.
GenevisibleiF6SEU4. MM.

Interactioni

Subunit structurei

Interacts KLHL17, CAMK2A and CAMK2B. Interacts with MPDZ (By similarity).By similarity

Protein-protein interaction databases

BioGridi232153. 5 interactors.
IntActiF6SEU4. 2 interactors.
STRINGi10090.ENSMUSP00000080038.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JXCX-ray2.50A/B/C/D/E/F1185-1274[»]
ProteinModelPortaliF6SEU4.
SMRiF6SEU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 251PHPROSITE-ProRule annotationAdd BLAST102
Domaini249 – 347C2Add BLAST99
Domaini443 – 635Ras-GAPPROSITE-ProRule annotationAdd BLAST193

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi785 – 815SH3-bindingSequence analysisAdd BLAST31

Domaini

The C2 domain is required for RapGAP activity.By similarity

Sequence similaritiesi

Contains 1 C2 domain.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Ras-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG3508. Eukaryota.
ENOG410XPU1. LUCA.
GeneTreeiENSGT00760000119092.
InParanoidiF6SEU4.
KOiK17631.
OMAiRDHPTMA.
OrthoDBiEOG091G00ZZ.
TreeFamiTF105303.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.20.170.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR021887. DUF3498.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR023315. SynGAP_C2_N.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF12004. DUF3498. 1 hit.
PF00616. RasGAP. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6SEU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSRASIHR GSIPAMSYAP FRDVRGPPMH RTQYVHSPYD RPGWNPRFCI
60 70 80 90 100
ISGNQLLMLD EDEIHPLLIR DRRSESSRNK LLRRTVSVPV EGRPHGEHEY
110 120 130 140 150
HLGRSRRKSV PGGKQYSMEA APAAPFRPSQ GFLSRRLKSS IKRTKSQPKL
160 170 180 190 200
DRTSSFRQIL PRFRSADHDR ARLMQSFKES HSHESLLSPS SAAEALELNL
210 220 230 240 250
DEDSIIKPVH SSILGQEFCF EVTTSSGTKC FACRSAAERD KWIENLQRAV
260 270 280 290 300
KPNKDNSRRV DNVLKLWIIE ARELPPKKRY YCELCLDDML YARTTSKPRS
310 320 330 340 350
ASGDTVFWGE HFEFNNLPAV RALRLHLYRD SDKKRKKDKA GYVGLVTVPV
360 370 380 390 400
ATLAGRHFTE QWYPVTLPTG SGGSGGMGSG GGGGSGGGSG GKGKGGCPAV
410 420 430 440 450
RLKARYQTMS ILPMELYKEF AEYVTNHYRM LCAVLEPALN VKGKEEVASA
460 470 480 490 500
LVHILQSTGK AKDFLSDMAM SEVDRFMERE HLIFRENTLA TKAIEEYMRL
510 520 530 540 550
IGQKYLKDAI GEFIRALYES EENCEVDPIK CTASSLAEHQ ANLRMCCELA
560 570 580 590 600
LCKVVNSHCV FPRELKEVFA SWRLRCAERG REDIADRLIS ASLFLRFLCP
610 620 630 640 650
AIMSPSLFGL MQEYPDEQTS RTLTLIAKVI QNLANFSKFT SKEDFLGFMN
660 670 680 690 700
EFLELEWGSM QQFLYEISNL DTLTNSSSFE GYIDLGRELS TLHALLWEVL
710 720 730 740 750
PQLSKEALLK LGPLPRLLND ISTALRNPNI QRQPSRQSER TRSQPMVLRG
760 770 780 790 800
PSAEMQGYMM RDLNSSIDLQ SFMARGLNSS MDMARLPSPT KEKPPPPPPG
810 820 830 840 850
GGKDLFYVSR PPLARSSPAY CTSSSDITEP EQKMLSVNKS VSMLDLQGDG
860 870 880 890 900
PGGRLNSSSV SNLAAVGDLL HSSQASLTAA LGLRPAPAGR LSQGSGSSIT
910 920 930 940 950
AAGMRLSQMG VTTDGVPAQQ LRIPLSFQNP LFHMAADGPG PPAGHGGSSG
960 970 980 990 1000
HGPPSSHHHH HHHHHHRGGE PPGDTFAPFH GYSKSEDLSS GVPKPPAASI
1010 1020 1030 1040 1050
LHSHSYSDEF GPSGTDFTRR QLSLQDSLQH MLSPPQITIG PQRPAPSGPG
1060 1070 1080 1090 1100
GGSGGGSGGG QPPPLQRGKS QQLTVSAAQK PRPSSGNLLQ SPEPSYGPAR
1110 1120 1130 1140 1150
PRQQSLSKEG SIGGSGGSGG GGGGGLKPSI TKQHSQTPST LNPTMPASER
1160 1170 1180 1190 1200
TVAWVSNMPH LSADIESAHI EREEYKLKEY SKSMDESRLD RVKEYEEEIH
1210 1220 1230 1240 1250
SLKERLHMSN RKLEEYERRL LSQEEQTSKI LMQYQARLEQ SEKRLRQQQV
1260 1270 1280 1290 1300
EKDSQIKSII GRLMLVEEEL RRDHPAMAEP LPEPKKRLLD AQERQLPPLG
1310 1320 1330 1340
PTNPRVTLAP PWNGLAPPAP PPPPRLQITE NGEFRNTADH
Length:1,340
Mass (Da):148,238
Last modified:December 14, 2011 - v2
Checksum:i4D2E4FB4F33E63D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC144621 Genomic DNA. No translation available.
CCDSiCCDS59625.1.
RefSeqiNP_001268420.1. NM_001281491.1.
UniGeneiMm.328888.

Genome annotation databases

EnsembliENSMUST00000194598; ENSMUSP00000141686; ENSMUSG00000067629.
GeneIDi240057.
KEGGimmu:240057.
UCSCiuc008bfa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC144621 Genomic DNA. No translation available.
CCDSiCCDS59625.1.
RefSeqiNP_001268420.1. NM_001281491.1.
UniGeneiMm.328888.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JXCX-ray2.50A/B/C/D/E/F1185-1274[»]
ProteinModelPortaliF6SEU4.
SMRiF6SEU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232153. 5 interactors.
IntActiF6SEU4. 2 interactors.
STRINGi10090.ENSMUSP00000080038.

PTM databases

iPTMnetiF6SEU4.
PhosphoSitePlusiF6SEU4.
SwissPalmiF6SEU4.

Proteomic databases

MaxQBiF6SEU4.
PaxDbiF6SEU4.
PeptideAtlasiF6SEU4.
PRIDEiF6SEU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000194598; ENSMUSP00000141686; ENSMUSG00000067629.
GeneIDi240057.
KEGGimmu:240057.
UCSCiuc008bfa.2. mouse.

Organism-specific databases

CTDi8831.
MGIiMGI:3039785. Syngap1.

Phylogenomic databases

eggNOGiKOG3508. Eukaryota.
ENOG410XPU1. LUCA.
GeneTreeiENSGT00760000119092.
InParanoidiF6SEU4.
KOiK17631.
OMAiRDHPTMA.
OrthoDBiEOG091G00ZZ.
TreeFamiTF105303.

Enzyme and pathway databases

ReactomeiR-MMU-5658442. Regulation of RAS by GAPs.
R-MMU-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.

Miscellaneous databases

PROiF6SEU4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067629.
ExpressionAtlasiF6SEU4. baseline and differential.
GenevisibleiF6SEU4. MM.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.20.170.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR021887. DUF3498.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR023315. SynGAP_C2_N.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF12004. DUF3498. 1 hit.
PF00616. RasGAP. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYGP1_MOUSE
AccessioniPrimary (citable) accession number: F6SEU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 30, 2016
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.