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F6SEU4

- SYGP1_MOUSE

UniProt

F6SEU4 - SYGP1_MOUSE

Protein

Ras/Rap GTPase-activating protein SynGAP

Gene

Syngap1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 2 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. Rab GTPase activator activity Source: MGI

    GO - Biological processi

    1. dendrite development Source: MGI
    2. negative regulation of axonogenesis Source: MGI
    3. negative regulation of neuron apoptotic process Source: MGI
    4. negative regulation of Ras protein signal transduction Source: UniProtKB
    5. pattern specification process Source: MGI
    6. positive regulation of Rab GTPase activity Source: GOC
    7. positive regulation of Ras GTPase activity Source: RefGenome
    8. Ras protein signal transduction Source: MGI
    9. receptor clustering Source: MGI
    10. regulation of long-term neuronal synaptic plasticity Source: MGI
    11. regulation of MAPK cascade Source: MGI
    12. regulation of synapse structure and activity Source: MGI
    13. regulation of synaptic plasticity Source: UniProtKB
    14. visual learning Source: MGI

    Keywords - Molecular functioni

    GTPase activation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras/Rap GTPase-activating protein SynGAP
    Alternative name(s):
    Neuronal RasGAP
    Synaptic Ras GTPase-activating protein 1
    Short name:
    Synaptic Ras-GAP 1
    Gene namesi
    Name:Syngap1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:3039785. Syngap1.

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity. Cell junctionsynapse By similarity
    Note: Mostly in excitatory glutamatergic synapses By similarity. receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity By similarity.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasm Source: RefGenome
    3. dendritic shaft Source: MGI
    4. intrinsic component of the cytoplasmic side of the plasma membrane Source: RefGenome
    5. membrane Source: MGI
    6. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13401340Ras/Rap GTPase-activating protein SynGAPPRO_0000414716Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei34 – 341Phosphotyrosine1 Publication
    Modified residuei39 – 391Phosphotyrosine1 Publication
    Modified residuei379 – 3791Phosphoserine; by PLK2By similarity
    Modified residuei385 – 3851Phosphoserine; by PLK2By similarity
    Modified residuei449 – 4491Phosphoserine; by PLK2By similarity
    Modified residuei466 – 4661Phosphoserine; by PLK2By similarity
    Modified residuei836 – 8361Phosphoserine; by PLK2By similarity
    Modified residuei840 – 8401Phosphoserine; by PLK2By similarity
    Modified residuei842 – 8421Phosphoserine; by PLK2By similarity
    Modified residuei895 – 8951Phosphoserine; by PLK2By similarity
    Modified residuei1201 – 12011Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiF6SEU4.

    Expressioni

    Gene expression databases

    BgeeiF6SEU4.

    Interactioni

    Subunit structurei

    Interacts KLHL17, CAMK2A and CAMK2B. Interacts with MPDZ By similarity.By similarity

    Protein-protein interaction databases

    IntActiF6SEU4. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliF6SEU4.
    SMRiF6SEU4. Positions 401-734.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini150 – 251102PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini249 – 34799C2Add
    BLAST
    Domaini443 – 635193Ras-GAPPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi785 – 81531SH3-bindingSequence AnalysisAdd
    BLAST

    Domaini

    The C2 domain is required for RapGAP activity.By similarity

    Sequence similaritiesi

    Contains 1 C2 domain.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 Ras-GAP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3-binding

    Phylogenomic databases

    GeneTreeiENSGT00600000084217.
    KOiK17631.
    OMAiNPHIQRQ.
    OrthoDBiEOG74XS5P.
    TreeFamiTF105303.

    Family and domain databases

    Gene3Di1.10.506.10. 1 hit.
    2.20.170.10. 1 hit.
    2.30.29.30. 2 hits.
    2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR021887. DUF3498.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001936. RasGAP.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    IPR023315. SynGAP_C2_N.
    [Graphical view]
    PfamiPF00168. C2. 1 hit.
    PF12004. DUF3498. 1 hit.
    PF00616. RasGAP. 1 hit.
    [Graphical view]
    SMARTiSM00239. C2. 1 hit.
    SM00233. PH. 1 hit.
    SM00323. RasGAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF49562. SSF49562. 1 hit.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6SEU4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRSRASIHR GSIPAMSYAP FRDVRGPPMH RTQYVHSPYD RPGWNPRFCI     50
    ISGNQLLMLD EDEIHPLLIR DRRSESSRNK LLRRTVSVPV EGRPHGEHEY 100
    HLGRSRRKSV PGGKQYSMEA APAAPFRPSQ GFLSRRLKSS IKRTKSQPKL 150
    DRTSSFRQIL PRFRSADHDR ARLMQSFKES HSHESLLSPS SAAEALELNL 200
    DEDSIIKPVH SSILGQEFCF EVTTSSGTKC FACRSAAERD KWIENLQRAV 250
    KPNKDNSRRV DNVLKLWIIE ARELPPKKRY YCELCLDDML YARTTSKPRS 300
    ASGDTVFWGE HFEFNNLPAV RALRLHLYRD SDKKRKKDKA GYVGLVTVPV 350
    ATLAGRHFTE QWYPVTLPTG SGGSGGMGSG GGGGSGGGSG GKGKGGCPAV 400
    RLKARYQTMS ILPMELYKEF AEYVTNHYRM LCAVLEPALN VKGKEEVASA 450
    LVHILQSTGK AKDFLSDMAM SEVDRFMERE HLIFRENTLA TKAIEEYMRL 500
    IGQKYLKDAI GEFIRALYES EENCEVDPIK CTASSLAEHQ ANLRMCCELA 550
    LCKVVNSHCV FPRELKEVFA SWRLRCAERG REDIADRLIS ASLFLRFLCP 600
    AIMSPSLFGL MQEYPDEQTS RTLTLIAKVI QNLANFSKFT SKEDFLGFMN 650
    EFLELEWGSM QQFLYEISNL DTLTNSSSFE GYIDLGRELS TLHALLWEVL 700
    PQLSKEALLK LGPLPRLLND ISTALRNPNI QRQPSRQSER TRSQPMVLRG 750
    PSAEMQGYMM RDLNSSIDLQ SFMARGLNSS MDMARLPSPT KEKPPPPPPG 800
    GGKDLFYVSR PPLARSSPAY CTSSSDITEP EQKMLSVNKS VSMLDLQGDG 850
    PGGRLNSSSV SNLAAVGDLL HSSQASLTAA LGLRPAPAGR LSQGSGSSIT 900
    AAGMRLSQMG VTTDGVPAQQ LRIPLSFQNP LFHMAADGPG PPAGHGGSSG 950
    HGPPSSHHHH HHHHHHRGGE PPGDTFAPFH GYSKSEDLSS GVPKPPAASI 1000
    LHSHSYSDEF GPSGTDFTRR QLSLQDSLQH MLSPPQITIG PQRPAPSGPG 1050
    GGSGGGSGGG QPPPLQRGKS QQLTVSAAQK PRPSSGNLLQ SPEPSYGPAR 1100
    PRQQSLSKEG SIGGSGGSGG GGGGGLKPSI TKQHSQTPST LNPTMPASER 1150
    TVAWVSNMPH LSADIESAHI EREEYKLKEY SKSMDESRLD RVKEYEEEIH 1200
    SLKERLHMSN RKLEEYERRL LSQEEQTSKI LMQYQARLEQ SEKRLRQQQV 1250
    EKDSQIKSII GRLMLVEEEL RRDHPAMAEP LPEPKKRLLD AQERQLPPLG 1300
    PTNPRVTLAP PWNGLAPPAP PPPPRLQITE NGEFRNTADH 1340
    Length:1,340
    Mass (Da):148,238
    Last modified:December 14, 2011 - v2
    Checksum:i4D2E4FB4F33E63D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC144621 Genomic DNA. No translation available.
    CCDSiCCDS59625.1.
    RefSeqiNP_001268420.1. NM_001281491.1.
    UniGeneiMm.328888.

    Genome annotation databases

    EnsembliENSMUST00000081285; ENSMUSP00000080038; ENSMUSG00000067629.
    GeneIDi240057.
    KEGGimmu:240057.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC144621 Genomic DNA. No translation available.
    CCDSi CCDS59625.1.
    RefSeqi NP_001268420.1. NM_001281491.1.
    UniGenei Mm.328888.

    3D structure databases

    ProteinModelPortali F6SEU4.
    SMRi F6SEU4. Positions 401-734.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi F6SEU4. 2 interactions.

    Proteomic databases

    PRIDEi F6SEU4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000081285 ; ENSMUSP00000080038 ; ENSMUSG00000067629 .
    GeneIDi 240057.
    KEGGi mmu:240057.

    Organism-specific databases

    CTDi 8831.
    MGIi MGI:3039785. Syngap1.

    Phylogenomic databases

    GeneTreei ENSGT00600000084217.
    KOi K17631.
    OMAi NPHIQRQ.
    OrthoDBi EOG74XS5P.
    TreeFami TF105303.

    Miscellaneous databases

    NextBioi 384399.
    PROi F6SEU4.
    SOURCEi Search...

    Gene expression databases

    Bgeei F6SEU4.

    Family and domain databases

    Gene3Di 1.10.506.10. 1 hit.
    2.20.170.10. 1 hit.
    2.30.29.30. 2 hits.
    2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR021887. DUF3498.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR001936. RasGAP.
    IPR023152. RasGAP_CS.
    IPR008936. Rho_GTPase_activation_prot.
    IPR023315. SynGAP_C2_N.
    [Graphical view ]
    Pfami PF00168. C2. 1 hit.
    PF12004. DUF3498. 1 hit.
    PF00616. RasGAP. 1 hit.
    [Graphical view ]
    SMARTi SM00239. C2. 1 hit.
    SM00233. PH. 1 hit.
    SM00323. RasGAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF49562. SSF49562. 1 hit.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
    PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1201, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    3. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-34 AND TYR-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiSYGP1_MOUSE
    AccessioniPrimary (citable) accession number: F6SEU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 31 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3