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Protein

Ras/Rap GTPase-activating protein SynGAP

Gene

Syngap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).By similarity

GO - Molecular functioni

  • GTPase activator activity Source: MGI

GO - Biological processi

  • dendrite development Source: MGI
  • negative regulation of axonogenesis Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of Ras protein signal transduction Source: UniProtKB
  • pattern specification process Source: MGI
  • positive regulation of GTPase activity Source: GOC
  • Ras protein signal transduction Source: MGI
  • receptor clustering Source: MGI
  • regulation of long-term neuronal synaptic plasticity Source: MGI
  • regulation of MAPK cascade Source: MGI
  • regulation of synapse structure or activity Source: MGI
  • regulation of synaptic plasticity Source: UniProtKB
  • visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras/Rap GTPase-activating protein SynGAP
Alternative name(s):
Neuronal RasGAP
Synaptic Ras GTPase-activating protein 1
Short name:
Synaptic Ras-GAP 1
Gene namesi
Name:Syngap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3039785. Syngap1.

Subcellular locationi

  • Membrane By similarity; Peripheral membrane protein By similarity
  • Cell junctionsynapse By similarity

  • Note: Mostly in excitatory glutamatergic synapses (By similarity). receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity (By similarity).By similarity

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: GO_Central
  • dendritic shaft Source: MGI
  • intrinsic component of the cytoplasmic side of the plasma membrane Source: GO_Central
  • membrane Source: MGI
  • neuronal postsynaptic density Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13401340Ras/Rap GTPase-activating protein SynGAPPRO_0000414716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341Phosphotyrosine1 Publication
Modified residuei39 – 391Phosphotyrosine1 Publication
Modified residuei379 – 3791Phosphoserine; by PLK2By similarity
Modified residuei385 – 3851Phosphoserine; by PLK2By similarity
Modified residuei449 – 4491Phosphoserine; by PLK2By similarity
Modified residuei466 – 4661Phosphoserine; by PLK2By similarity
Modified residuei836 – 8361Phosphoserine; by PLK2By similarity
Modified residuei840 – 8401Phosphoserine; by PLK2By similarity
Modified residuei842 – 8421Phosphoserine; by PLK2By similarity
Modified residuei895 – 8951Phosphoserine; by PLK2By similarity
Modified residuei1201 – 12011Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiF6SEU4.

Expressioni

Gene expression databases

BgeeiF6SEU4.
ExpressionAtlasiF6SEU4. baseline and differential.

Interactioni

Subunit structurei

Interacts KLHL17, CAMK2A and CAMK2B. Interacts with MPDZ (By similarity).By similarity

Protein-protein interaction databases

BioGridi232153. 5 interactions.
IntActiF6SEU4. 2 interactions.
STRINGi10090.ENSMUSP00000080038.

Structurei

3D structure databases

ProteinModelPortaliF6SEU4.
SMRiF6SEU4. Positions 401-734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 251102PHPROSITE-ProRule annotationAdd
BLAST
Domaini249 – 34799C2Add
BLAST
Domaini443 – 635193Ras-GAPPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi785 – 81531SH3-bindingSequence AnalysisAdd
BLAST

Domaini

The C2 domain is required for RapGAP activity.By similarity

Sequence similaritiesi

Contains 1 C2 domain.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Ras-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3-binding

Phylogenomic databases

GeneTreeiENSGT00760000119092.
InParanoidiF6SEU4.
KOiK17631.
OMAiHPTMAEP.
OrthoDBiEOG74XS5P.
TreeFamiTF105303.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.20.170.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR021887. DUF3498.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR023315. SynGAP_C2_N.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF12004. DUF3498. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6SEU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSRASIHR GSIPAMSYAP FRDVRGPPMH RTQYVHSPYD RPGWNPRFCI
60 70 80 90 100
ISGNQLLMLD EDEIHPLLIR DRRSESSRNK LLRRTVSVPV EGRPHGEHEY
110 120 130 140 150
HLGRSRRKSV PGGKQYSMEA APAAPFRPSQ GFLSRRLKSS IKRTKSQPKL
160 170 180 190 200
DRTSSFRQIL PRFRSADHDR ARLMQSFKES HSHESLLSPS SAAEALELNL
210 220 230 240 250
DEDSIIKPVH SSILGQEFCF EVTTSSGTKC FACRSAAERD KWIENLQRAV
260 270 280 290 300
KPNKDNSRRV DNVLKLWIIE ARELPPKKRY YCELCLDDML YARTTSKPRS
310 320 330 340 350
ASGDTVFWGE HFEFNNLPAV RALRLHLYRD SDKKRKKDKA GYVGLVTVPV
360 370 380 390 400
ATLAGRHFTE QWYPVTLPTG SGGSGGMGSG GGGGSGGGSG GKGKGGCPAV
410 420 430 440 450
RLKARYQTMS ILPMELYKEF AEYVTNHYRM LCAVLEPALN VKGKEEVASA
460 470 480 490 500
LVHILQSTGK AKDFLSDMAM SEVDRFMERE HLIFRENTLA TKAIEEYMRL
510 520 530 540 550
IGQKYLKDAI GEFIRALYES EENCEVDPIK CTASSLAEHQ ANLRMCCELA
560 570 580 590 600
LCKVVNSHCV FPRELKEVFA SWRLRCAERG REDIADRLIS ASLFLRFLCP
610 620 630 640 650
AIMSPSLFGL MQEYPDEQTS RTLTLIAKVI QNLANFSKFT SKEDFLGFMN
660 670 680 690 700
EFLELEWGSM QQFLYEISNL DTLTNSSSFE GYIDLGRELS TLHALLWEVL
710 720 730 740 750
PQLSKEALLK LGPLPRLLND ISTALRNPNI QRQPSRQSER TRSQPMVLRG
760 770 780 790 800
PSAEMQGYMM RDLNSSIDLQ SFMARGLNSS MDMARLPSPT KEKPPPPPPG
810 820 830 840 850
GGKDLFYVSR PPLARSSPAY CTSSSDITEP EQKMLSVNKS VSMLDLQGDG
860 870 880 890 900
PGGRLNSSSV SNLAAVGDLL HSSQASLTAA LGLRPAPAGR LSQGSGSSIT
910 920 930 940 950
AAGMRLSQMG VTTDGVPAQQ LRIPLSFQNP LFHMAADGPG PPAGHGGSSG
960 970 980 990 1000
HGPPSSHHHH HHHHHHRGGE PPGDTFAPFH GYSKSEDLSS GVPKPPAASI
1010 1020 1030 1040 1050
LHSHSYSDEF GPSGTDFTRR QLSLQDSLQH MLSPPQITIG PQRPAPSGPG
1060 1070 1080 1090 1100
GGSGGGSGGG QPPPLQRGKS QQLTVSAAQK PRPSSGNLLQ SPEPSYGPAR
1110 1120 1130 1140 1150
PRQQSLSKEG SIGGSGGSGG GGGGGLKPSI TKQHSQTPST LNPTMPASER
1160 1170 1180 1190 1200
TVAWVSNMPH LSADIESAHI EREEYKLKEY SKSMDESRLD RVKEYEEEIH
1210 1220 1230 1240 1250
SLKERLHMSN RKLEEYERRL LSQEEQTSKI LMQYQARLEQ SEKRLRQQQV
1260 1270 1280 1290 1300
EKDSQIKSII GRLMLVEEEL RRDHPAMAEP LPEPKKRLLD AQERQLPPLG
1310 1320 1330 1340
PTNPRVTLAP PWNGLAPPAP PPPPRLQITE NGEFRNTADH
Length:1,340
Mass (Da):148,238
Last modified:December 14, 2011 - v2
Checksum:i4D2E4FB4F33E63D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC144621 Genomic DNA. No translation available.
CCDSiCCDS59625.1.
RefSeqiNP_001268420.1. NM_001281491.1.
UniGeneiMm.328888.

Genome annotation databases

EnsembliENSMUST00000194598; ENSMUSP00000141686; ENSMUSG00000067629.
GeneIDi240057.
KEGGimmu:240057.
UCSCiuc008bfa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC144621 Genomic DNA. No translation available.
CCDSiCCDS59625.1.
RefSeqiNP_001268420.1. NM_001281491.1.
UniGeneiMm.328888.

3D structure databases

ProteinModelPortaliF6SEU4.
SMRiF6SEU4. Positions 401-734.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232153. 5 interactions.
IntActiF6SEU4. 2 interactions.
STRINGi10090.ENSMUSP00000080038.

Proteomic databases

PRIDEiF6SEU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000194598; ENSMUSP00000141686; ENSMUSG00000067629.
GeneIDi240057.
KEGGimmu:240057.
UCSCiuc008bfa.2. mouse.

Organism-specific databases

CTDi8831.
MGIiMGI:3039785. Syngap1.

Phylogenomic databases

GeneTreeiENSGT00760000119092.
InParanoidiF6SEU4.
KOiK17631.
OMAiHPTMAEP.
OrthoDBiEOG74XS5P.
TreeFamiTF105303.

Miscellaneous databases

NextBioi384399.
PROiF6SEU4.
SOURCEiSearch...

Gene expression databases

BgeeiF6SEU4.
ExpressionAtlasiF6SEU4. baseline and differential.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.20.170.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR021887. DUF3498.
IPR011993. PH-like_dom.
IPR001849. PH_domain.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR023315. SynGAP_C2_N.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF12004. DUF3498. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1201, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  3. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-34 AND TYR-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiSYGP1_MOUSE
AccessioniPrimary (citable) accession number: F6SEU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: December 14, 2011
Last modified: July 22, 2015
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.