Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

F6SEU4 (SYGP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras/Rap GTPase-activating protein SynGAP
Alternative name(s):
Neuronal RasGAP
Synaptic Ras GTPase-activating protein 1
Short name=Synaptic Ras-GAP 1
Gene names
Name:Syngap1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1340 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits By similarity.

Subunit structure

Interacts KLHL17, CAMK2A and CAMK2B. Interacts with MPDZ By similarity.

Subcellular location

Membrane; Peripheral membrane protein By similarity. Cell junctionsynapse By similarity. Note: Mostly in excitatory glutamatergic synapses By similarity. receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity By similarity.

Domain

The C2 domain is required for RapGAP activity By similarity.

Sequence similarities

Contains 1 C2 domain.

Contains 1 PH domain.

Contains 1 Ras-GAP domain.

Ontologies

Keywords
   Cellular componentCell junction
Membrane
Synapse
   DomainSH3-binding
   Molecular functionGTPase activation
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRas protein signal transduction

Inferred from direct assay PubMed 15014045. Source: MGI

dendrite development

Inferred from mutant phenotype PubMed 15470153. Source: MGI

negative regulation of Ras protein signal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of axonogenesis

Inferred from direct assay PubMed 15014045. Source: MGI

negative regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 15733080. Source: MGI

pattern specification process

Inferred from mutant phenotype PubMed 16452659. Source: MGI

positive regulation of Rab GTPase activity

Inferred from direct assay PubMed 15014045. Source: GOC

positive regulation of Ras GTPase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

receptor clustering

Inferred from mutant phenotype PubMed 12598599. Source: MGI

regulation of MAPK cascade

Inferred from mutant phenotype PubMed 12427827. Source: MGI

regulation of long-term neuronal synaptic plasticity

Inferred from mutant phenotype PubMed 12427827PubMed 15781580. Source: MGI

regulation of synapse structure and activity

Inferred from mutant phenotype PubMed 15470153. Source: MGI

regulation of synaptic plasticity

Inferred from sequence or structural similarity. Source: UniProtKB

visual learning

Inferred from mutant phenotype PubMed 12427827. Source: MGI

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

cytoplasm

Inferred from Biological aspect of Ancestor. Source: RefGenome

dendritic shaft

Inferred from direct assay PubMed 16452659. Source: MGI

intrinsic component of the cytoplasmic side of the plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

membrane

Inferred from direct assay PubMed 15014045. Source: MGI

synapse

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRab GTPase activator activity

Inferred from direct assay PubMed 15014045. Source: MGI

protein binding

Inferred from physical interaction PubMed 15014045. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13401340Ras/Rap GTPase-activating protein SynGAP
PRO_0000414716

Regions

Domain150 – 251102PH
Domain249 – 34799C2
Domain443 – 635193Ras-GAP
Motif785 – 81531SH3-binding Potential

Amino acid modifications

Modified residue341Phosphotyrosine Ref.3
Modified residue391Phosphotyrosine Ref.3
Modified residue3791Phosphoserine; by PLK2 By similarity
Modified residue3851Phosphoserine; by PLK2 By similarity
Modified residue4491Phosphoserine; by PLK2 By similarity
Modified residue4661Phosphoserine; by PLK2 By similarity
Modified residue8361Phosphoserine; by PLK2 By similarity
Modified residue8401Phosphoserine; by PLK2 By similarity
Modified residue8421Phosphoserine; by PLK2 By similarity
Modified residue8951Phosphoserine; by PLK2 By similarity
Modified residue12011Phosphoserine Ref.2

Sequences

Sequence LengthMass (Da)Tools
F6SEU4 [UniParc].

Last modified December 14, 2011. Version 2.
Checksum: 4D2E4FB4F33E63D7

FASTA1,340148,238
        10         20         30         40         50         60 
MSRSRASIHR GSIPAMSYAP FRDVRGPPMH RTQYVHSPYD RPGWNPRFCI ISGNQLLMLD 

        70         80         90        100        110        120 
EDEIHPLLIR DRRSESSRNK LLRRTVSVPV EGRPHGEHEY HLGRSRRKSV PGGKQYSMEA 

       130        140        150        160        170        180 
APAAPFRPSQ GFLSRRLKSS IKRTKSQPKL DRTSSFRQIL PRFRSADHDR ARLMQSFKES 

       190        200        210        220        230        240 
HSHESLLSPS SAAEALELNL DEDSIIKPVH SSILGQEFCF EVTTSSGTKC FACRSAAERD 

       250        260        270        280        290        300 
KWIENLQRAV KPNKDNSRRV DNVLKLWIIE ARELPPKKRY YCELCLDDML YARTTSKPRS 

       310        320        330        340        350        360 
ASGDTVFWGE HFEFNNLPAV RALRLHLYRD SDKKRKKDKA GYVGLVTVPV ATLAGRHFTE 

       370        380        390        400        410        420 
QWYPVTLPTG SGGSGGMGSG GGGGSGGGSG GKGKGGCPAV RLKARYQTMS ILPMELYKEF 

       430        440        450        460        470        480 
AEYVTNHYRM LCAVLEPALN VKGKEEVASA LVHILQSTGK AKDFLSDMAM SEVDRFMERE 

       490        500        510        520        530        540 
HLIFRENTLA TKAIEEYMRL IGQKYLKDAI GEFIRALYES EENCEVDPIK CTASSLAEHQ 

       550        560        570        580        590        600 
ANLRMCCELA LCKVVNSHCV FPRELKEVFA SWRLRCAERG REDIADRLIS ASLFLRFLCP 

       610        620        630        640        650        660 
AIMSPSLFGL MQEYPDEQTS RTLTLIAKVI QNLANFSKFT SKEDFLGFMN EFLELEWGSM 

       670        680        690        700        710        720 
QQFLYEISNL DTLTNSSSFE GYIDLGRELS TLHALLWEVL PQLSKEALLK LGPLPRLLND 

       730        740        750        760        770        780 
ISTALRNPNI QRQPSRQSER TRSQPMVLRG PSAEMQGYMM RDLNSSIDLQ SFMARGLNSS 

       790        800        810        820        830        840 
MDMARLPSPT KEKPPPPPPG GGKDLFYVSR PPLARSSPAY CTSSSDITEP EQKMLSVNKS 

       850        860        870        880        890        900 
VSMLDLQGDG PGGRLNSSSV SNLAAVGDLL HSSQASLTAA LGLRPAPAGR LSQGSGSSIT 

       910        920        930        940        950        960 
AAGMRLSQMG VTTDGVPAQQ LRIPLSFQNP LFHMAADGPG PPAGHGGSSG HGPPSSHHHH 

       970        980        990       1000       1010       1020 
HHHHHHRGGE PPGDTFAPFH GYSKSEDLSS GVPKPPAASI LHSHSYSDEF GPSGTDFTRR 

      1030       1040       1050       1060       1070       1080 
QLSLQDSLQH MLSPPQITIG PQRPAPSGPG GGSGGGSGGG QPPPLQRGKS QQLTVSAAQK 

      1090       1100       1110       1120       1130       1140 
PRPSSGNLLQ SPEPSYGPAR PRQQSLSKEG SIGGSGGSGG GGGGGLKPSI TKQHSQTPST 

      1150       1160       1170       1180       1190       1200 
LNPTMPASER TVAWVSNMPH LSADIESAHI EREEYKLKEY SKSMDESRLD RVKEYEEEIH 

      1210       1220       1230       1240       1250       1260 
SLKERLHMSN RKLEEYERRL LSQEEQTSKI LMQYQARLEQ SEKRLRQQQV EKDSQIKSII 

      1270       1280       1290       1300       1310       1320 
GRLMLVEEEL RRDHPAMAEP LPEPKKRLLD AQERQLPPLG PTNPRVTLAP PWNGLAPPAP 

      1330       1340 
PPPPRLQITE NGEFRNTADH 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1201, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
[3]"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-34 AND TYR-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC144621 Genomic DNA. No translation available.
CCDSCCDS59625.1.
RefSeqNP_001268420.1. NM_001281491.1.
UniGeneMm.328888.

3D structure databases

ProteinModelPortalF6SEU4.
SMRF6SEU4. Positions 401-734.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActF6SEU4. 2 interactions.

Proteomic databases

PRIDEF6SEU4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000081285; ENSMUSP00000080038; ENSMUSG00000067629.
GeneID240057.
KEGGmmu:240057.

Organism-specific databases

CTD8831.
MGIMGI:3039785. Syngap1.

Phylogenomic databases

GeneTreeENSGT00600000084217.
KOK17631.
OMANPHIQRQ.
OrthoDBEOG74XS5P.
TreeFamTF105303.

Gene expression databases

BgeeF6SEU4.

Family and domain databases

Gene3D1.10.506.10. 1 hit.
2.20.170.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProIPR000008. C2_dom.
IPR021887. DUF3498.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR023315. SynGAP_C2_N.
[Graphical view]
PfamPF00168. C2. 1 hit.
PF12004. DUF3498. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
SMARTSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEPS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio384399.
PROF6SEU4.
SOURCESearch...

Entry information

Entry nameSYGP1_MOUSE
AccessionPrimary (citable) accession number: F6SEU4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: December 14, 2011
Last modified: July 9, 2014
This is version 29 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot