Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

F6S675

- IMDH1_XENTR

UniProt

F6S675 - IMDH1_XENTR

Protein

Inosine-5'-monophosphate dehydrogenase 1

Gene

impdh1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.UniRule annotation

    Catalytic activityi

    Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

    Cofactori

    Potassium.UniRule annotation

    Enzyme regulationi

    Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi324 – 3241Potassium; via carbonyl oxygenUniRule annotation
    Metal bindingi326 – 3261Potassium; via carbonyl oxygenUniRule annotation
    Binding sitei327 – 3271IMPUniRule annotation
    Active sitei329 – 3291Thioimidate intermediateUniRule annotation
    Metal bindingi329 – 3291Potassium; via carbonyl oxygenUniRule annotation
    Binding sitei439 – 4391IMPUniRule annotation
    Metal bindingi498 – 4981Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
    Metal bindingi499 – 4991Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
    Metal bindingi500 – 5001Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi272 – 2743NADUniRule annotation
    Nucleotide bindingi322 – 3243NADUniRule annotation

    GO - Molecular functioni

    1. adenyl nucleotide binding Source: InterPro
    2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
    3. metal ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. GMP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    GMP biosynthesis, Purine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Potassium

    Enzyme and pathway databases

    UniPathwayiUPA00601; UER00295.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inosine-5'-monophosphate dehydrogenase 1UniRule annotation (EC:1.1.1.205UniRule annotation)
    Short name:
    IMP dehydrogenase 1UniRule annotation
    Short name:
    IMPD 1UniRule annotation
    Short name:
    IMPDH 1UniRule annotation
    Gene namesi
    Name:impdh1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Inosine-5'-monophosphate dehydrogenase 1PRO_0000415678Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiF6S675.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini112 – 17160CBS 1UniRule annotationAdd
    BLAST
    Domaini177 – 23559CBS 2UniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni362 – 3643IMP bindingUniRule annotation
    Regioni385 – 3862IMP bindingUniRule annotation
    Regioni409 – 4135IMP bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the IMPDH/GMPR family.UniRule annotation
    Contains 2 CBS domains.UniRule annotation

    Keywords - Domaini

    CBS domain, Repeat

    Phylogenomic databases

    GeneTreeiENSGT00530000062923.
    OrthoDBiEOG7VTDMM.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01964. IMPDH.
    InterProiIPR013785. Aldolase_TIM.
    IPR000644. CBS_dom.
    IPR005990. IMP_DH.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view]
    PfamiPF00571. CBS. 2 hits.
    PF00478. IMPDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000130. IMPDH. 1 hit.
    SMARTiSM00116. CBS. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
    PROSITEiPS51371. CBS. 2 hits.
    PS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6S675-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADYLISGGT GYVPEDGLTA QHLFANSDGL TYNDFLILPG FIDFTADEVD    50
    LTSALTRKIT LKTPLISSPM DTVTESDMAI AMALMGGIGI IHHNCTPEFQ 100
    ANEVRKKFEQ GFITDPVVMS LNHTVGDVFE AKNRHGFSGI PVTETGKMGS 150
    KLVGIVTSRD IDFLTEKDYS TYLSEVMTKR DELVVAPAGV TLKEANEILQ 200
    RSKKGKLPIV NDSDELVAII ARTDLKKNRD YPLASKDCRK QLLCGAAIGT 250
    REDDKYRLDL LTQAGVDVVV LDSSQGNSVY QINMIHYIKQ KYPELQVVGG 300
    NVVTAAQAKN LIDAGVDALR VGMGCGSICI TQEVMACGRP QGTAVYKVAE 350
    YARRFGVPVI ADGGIQTVGH VVKALALGAS TVMMGSLLAA TTEAPGEYFF 400
    SDGVRLKKYR GMGSLDAMEK NTSSQKRYFS EGDKVKVAQG VSGSIQDKGS 450
    IHKFVPYLIA GIQHGCQDIG AKSLSILRSM MYSGELKLEK RTMSAQVEGG 500
    VHGLHSYEKR LY 512
    Length:512
    Mass (Da):55,454
    Last modified:July 27, 2011 - v1
    Checksum:i6FAEE3FAE9E12ED0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAMC01092195 Genomic DNA. No translation available.
    AAMC01092196 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSXETT00000065632; ENSXETP00000060849; ENSXETG00000023047.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAMC01092195 Genomic DNA. No translation available.
    AAMC01092196 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000065632 ; ENSXETP00000060849 ; ENSXETG00000023047 .

    Phylogenomic databases

    GeneTreei ENSGT00530000062923.
    OrthoDBi EOG7VTDMM.

    Enzyme and pathway databases

    UniPathwayi UPA00601 ; UER00295 .

    Gene expression databases

    Bgeei F6S675.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01964. IMPDH.
    InterProi IPR013785. Aldolase_TIM.
    IPR000644. CBS_dom.
    IPR005990. IMP_DH.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view ]
    Pfami PF00571. CBS. 2 hits.
    PF00478. IMPDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000130. IMPDH. 1 hit.
    SMARTi SM00116. CBS. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
    PROSITEi PS51371. CBS. 2 hits.
    PS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiIMDH1_XENTR
    AccessioniPrimary (citable) accession number: F6S675
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2012
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3