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F6S675

- IMDH1_XENTR

UniProt

F6S675 - IMDH1_XENTR

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Protein

Inosine-5'-monophosphate dehydrogenase 1

Gene

impdh1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi324 – 3241Potassium; via carbonyl oxygenUniRule annotation
Metal bindingi326 – 3261Potassium; via carbonyl oxygenUniRule annotation
Binding sitei327 – 3271IMPUniRule annotation
Active sitei329 – 3291Thioimidate intermediateUniRule annotation
Metal bindingi329 – 3291Potassium; via carbonyl oxygenUniRule annotation
Binding sitei439 – 4391IMPUniRule annotation
Metal bindingi498 – 4981Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
Metal bindingi499 – 4991Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
Metal bindingi500 – 5001Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi272 – 2743NADUniRule annotation
Nucleotide bindingi322 – 3243NADUniRule annotation

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro
  2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenase 1UniRule annotation (EC:1.1.1.205UniRule annotation)
Short name:
IMP dehydrogenase 1UniRule annotation
Short name:
IMPD 1UniRule annotation
Short name:
IMPDH 1UniRule annotation
Gene namesi
Name:impdh1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Subcellular locationi

Cytoplasm UniRule annotation. Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Inosine-5'-monophosphate dehydrogenase 1PRO_0000415678Add
BLAST

Expressioni

Gene expression databases

BgeeiF6S675.
ExpressionAtlasiF6S675. baseline.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 17160CBS 1UniRule annotationAdd
BLAST
Domaini177 – 23559CBS 2UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni362 – 3643IMP bindingUniRule annotation
Regioni385 – 3862IMP bindingUniRule annotation
Regioni409 – 4135IMP bindingUniRule annotation

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.UniRule annotation
Contains 2 CBS domains.UniRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

GeneTreeiENSGT00530000062923.
InParanoidiF6S675.
OrthoDBiEOG7VTDMM.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6S675-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADYLISGGT GYVPEDGLTA QHLFANSDGL TYNDFLILPG FIDFTADEVD
60 70 80 90 100
LTSALTRKIT LKTPLISSPM DTVTESDMAI AMALMGGIGI IHHNCTPEFQ
110 120 130 140 150
ANEVRKKFEQ GFITDPVVMS LNHTVGDVFE AKNRHGFSGI PVTETGKMGS
160 170 180 190 200
KLVGIVTSRD IDFLTEKDYS TYLSEVMTKR DELVVAPAGV TLKEANEILQ
210 220 230 240 250
RSKKGKLPIV NDSDELVAII ARTDLKKNRD YPLASKDCRK QLLCGAAIGT
260 270 280 290 300
REDDKYRLDL LTQAGVDVVV LDSSQGNSVY QINMIHYIKQ KYPELQVVGG
310 320 330 340 350
NVVTAAQAKN LIDAGVDALR VGMGCGSICI TQEVMACGRP QGTAVYKVAE
360 370 380 390 400
YARRFGVPVI ADGGIQTVGH VVKALALGAS TVMMGSLLAA TTEAPGEYFF
410 420 430 440 450
SDGVRLKKYR GMGSLDAMEK NTSSQKRYFS EGDKVKVAQG VSGSIQDKGS
460 470 480 490 500
IHKFVPYLIA GIQHGCQDIG AKSLSILRSM MYSGELKLEK RTMSAQVEGG
510
VHGLHSYEKR LY
Length:512
Mass (Da):55,454
Last modified:July 27, 2011 - v1
Checksum:i6FAEE3FAE9E12ED0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAMC01092195 Genomic DNA. No translation available.
AAMC01092196 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSXETT00000065632; ENSXETP00000060849; ENSXETG00000023047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAMC01092195 Genomic DNA. No translation available.
AAMC01092196 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000065632 ; ENSXETP00000060849 ; ENSXETG00000023047 .

Phylogenomic databases

GeneTreei ENSGT00530000062923.
InParanoidi F6S675.
OrthoDBi EOG7VTDMM.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .

Gene expression databases

Bgeei F6S675.
ExpressionAtlasi F6S675. baseline.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiIMDH1_XENTR
AccessioniPrimary (citable) accession number: F6S675
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3