F6RY50 (F6RY50_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Signal-induced proliferation-associated protein 1 Ensembl ENSP00000377774 Ensembl ENSP00000433686

Gene names

Name:

SIPA1 Ensembl ENSP00000377774 Ensembl ENSP00000433686

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000433686

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	940 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 PDZ (DHR) domain. RuleBase RU003354
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000377774 Ensembl ENSP00000433686

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC regulation of small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	GTPase activator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F6RY50 [UniParc]. Last modified July 27, 2011. Version 1. Checksum: 130336CF122946D8	FASTA	940	101,823
	10 20 30 40 50 60 MPMWAGGVGS PRRGMAPAST DDLFARKLRQ PARPPLTPHT FEPRPVRGPL LRSGSDAGEA 70 80 90 100 110 120 RPPTPASPRA RAHSHEEASR PAATSTRLFT DPLALLGLPA EEPEPAFPPV LEPRWFAHYD 130 140 150 160 170 180 VQSLLFDWAP RSQGMGSHSE ASSGTLASAE DQAASSDLLH GAPGFVCELG GEGELGLGGP 190 200 210 220 230 240 ASPPVPPALP NAAVSILEEP QNRTSAYSLE HADLGAGYYR KYFYGKEHQN FFGMDESLGP 250 260 270 280 290 300 VAVSLRREEK EGSGGGTLHS YRVIVRTTQL RTLRGTISED ALPPGPPRGL SPRKLLEHVA 310 320 330 340 350 360 PQLSPSCLRL GSASPKVPRT LLTLDEQVLS FQRKVGILYC RAGQGSEEEM YNNQEAGPAF 370 380 390 400 410 420 MQFLTLLGDV VRLKGFESYR AQLDTKTDST GTHSLYTTYQ DHEIMFHVST MLPYTPNNQQ 430 440 450 460 470 480 QLLRKRHIGN DIVTIVFQEP GSKPFCPTTI RSHFQHVFLV VRAHTPCTPH TTYRVAVSRT 490 500 510 520 530 540 QDTPAFGPAL PAGGGPFAAN ADFRAFLLAK ALNGEQAAGH ARQFHAMATR TRQQYLQDLA 550 560 570 580 590 600 TNEQLDLYHG RGEAITLRFD GSPGQAVGEV VARLQLVSRG CETRELALPR DGQGRLGFEV 610 620 630 640 650 660 DAEGFVTHVE RFTFAETAGL RPGARLLRVC GQTLPSLRPE AAAQLLRSAP KVCVTVLPPD 670 680 690 700 710 720 ESGRPRRSFS ELYTLSLQEP SRRGAPDPVQ DEVQGVTLLP TTKQLLHLCL QDGGSPPGPG 730 740 750 760 770 780 DLAEERTEFL HSQNSLSPRS SLSDEAPVLP NTTPDLLLAT TAKPSVPSAD SETPLTQDRP 790 800 810 820 830 840 GSPSGSEDKG NPAPELRASF LPRTLSLRNS ISRIMSEAGS GTLEDEWQAI SEIASTCNTI 850 860 870 880 890 900 LESLSREGQP IPESGDPKGT PKSDAEPEPG NLSEKVSHLE SMLRKLQEDL QKEKADRAAL 910 920 930 940 EEEVRSLRHN NRRLQAESES AATRLLLASK QLGSPTADLA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP001362 Genomic DNA. No translation available.
IPI	IPI00910331.
3D structure databases
SMR	F6RY50. Positions 216-539.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000394227; ENSP00000377774; ENSG00000213445. ENST00000527525; ENSP00000433686; ENSG00000213445.
UCSC	uc010rom.1. human.
Organism-specific databases
HGNC	HGNC:10885. SIPA1.
GenAtlas	Search...
Gene expression databases
ArrayExpress	F6RY50.
Family and domain databases
InterPro	IPR001478. PDZ. IPR000331. Rap_GAP_dom. [Graphical view]
Pfam	PF00595. PDZ. 1 hit. PF02145. Rap_GAP. 1 hit. [Graphical view]
SMART	SM00228. PDZ. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit.
PROSITE	PS50106. PDZ. 1 hit. PS50085. RAPGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35510268.

Entry information

Entry name

F6RY50_HUMAN

Accession

Primary (citable) accession number: F6RY50

Entry history

Integrated into UniProtKB/TrEMBL:	July 27, 2011
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.