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F6RY50

- F6RY50_HUMAN

UniProt

F6RY50 - F6RY50_HUMAN

Protein
Submitted name:

Signal-induced proliferation-associated protein 1

Gene

SIPA1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. GTPase activator activity Source: InterPro

    GO - Biological processi

    1. regulation of small GTPase mediated signal transduction Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Signal-induced proliferation-associated protein 1Imported
    Gene namesi
    Name:SIPA1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:10885. SIPA1.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PDZ (DHR) domain.UniRule annotation

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    IPR000331. Rap_GAP_dom.
    [Graphical view]
    PfamiPF00595. PDZ. 1 hit.
    PF02145. Rap_GAP. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    PS50085. RAPGAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6RY50-1 [UniParc]FASTAAdd to Basket

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    MPMWAGGVGS PRRGMAPAST DDLFARKLRQ PARPPLTPHT FEPRPVRGPL    50
    LRSGSDAGEA RPPTPASPRA RAHSHEEASR PAATSTRLFT DPLALLGLPA 100
    EEPEPAFPPV LEPRWFAHYD VQSLLFDWAP RSQGMGSHSE ASSGTLASAE 150
    DQAASSDLLH GAPGFVCELG GEGELGLGGP ASPPVPPALP NAAVSILEEP 200
    QNRTSAYSLE HADLGAGYYR KYFYGKEHQN FFGMDESLGP VAVSLRREEK 250
    EGSGGGTLHS YRVIVRTTQL RTLRGTISED ALPPGPPRGL SPRKLLEHVA 300
    PQLSPSCLRL GSASPKVPRT LLTLDEQVLS FQRKVGILYC RAGQGSEEEM 350
    YNNQEAGPAF MQFLTLLGDV VRLKGFESYR AQLDTKTDST GTHSLYTTYQ 400
    DHEIMFHVST MLPYTPNNQQ QLLRKRHIGN DIVTIVFQEP GSKPFCPTTI 450
    RSHFQHVFLV VRAHTPCTPH TTYRVAVSRT QDTPAFGPAL PAGGGPFAAN 500
    ADFRAFLLAK ALNGEQAAGH ARQFHAMATR TRQQYLQDLA TNEQLDLYHG 550
    RGEAITLRFD GSPGQAVGEV VARLQLVSRG CETRELALPR DGQGRLGFEV 600
    DAEGFVTHVE RFTFAETAGL RPGARLLRVC GQTLPSLRPE AAAQLLRSAP 650
    KVCVTVLPPD ESGRPRRSFS ELYTLSLQEP SRRGAPDPVQ DEVQGVTLLP 700
    TTKQLLHLCL QDGGSPPGPG DLAEERTEFL HSQNSLSPRS SLSDEAPVLP 750
    NTTPDLLLAT TAKPSVPSAD SETPLTQDRP GSPSGSEDKG NPAPELRASF 800
    LPRTLSLRNS ISRIMSEAGS GTLEDEWQAI SEIASTCNTI LESLSREGQP 850
    IPESGDPKGT PKSDAEPEPG NLSEKVSHLE SMLRKLQEDL QKEKADRAAL 900
    EEEVRSLRHN NRRLQAESES AATRLLLASK QLGSPTADLA 940
    Length:940
    Mass (Da):101,823
    Last modified:July 27, 2011 - v1
    Checksum:i130336CF122946D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP001362 Genomic DNA. No translation available.
    KF455405 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000394227; ENSP00000377774; ENSG00000213445.
    ENST00000527525; ENSP00000433686; ENSG00000213445.
    UCSCiuc010rom.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP001362 Genomic DNA. No translation available.
    KF455405 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000394227 ; ENSP00000377774 ; ENSG00000213445 .
    ENST00000527525 ; ENSP00000433686 ; ENSG00000213445 .
    UCSCi uc010rom.1. human.

    Organism-specific databases

    HGNCi HGNC:10885. SIPA1.
    GenAtlasi Search...

    Miscellaneous databases

    NextBioi 35510268.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    IPR000331. Rap_GAP_dom.
    [Graphical view ]
    Pfami PF00595. PDZ. 1 hit.
    PF02145. Rap_GAP. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    PS50085. RAPGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.D., Yates J.R.
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
    8. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiF6RY50_HUMAN
    AccessioniPrimary (citable) accession number: F6RY50
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3