Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

F6RRD7

- RPAP2_BOVIN

UniProt

F6RRD7 - RPAP2_BOVIN

Protein

Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

Gene

RPAP2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri77 – 16084RTR1-typeAdd
    BLAST

    GO - Molecular functioni

    1. CTD phosphatase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dephosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
    2. snRNA transcription Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC:3.1.3.16)
    Alternative name(s):
    RNA polymerase II-associated protein 2
    Gene namesi
    Name:RPAP2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. DNA-directed RNA polymerase II, holoenzyme Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 608607Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2PRO_0000416288Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei432 – 4321PhosphoserineBy similarity
    Modified residuei479 – 4791PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Interactioni

    Subunit structurei

    Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000041791.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili33 – 6836Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RPAP2 family.Curated
    Contains 1 RTR1-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri77 – 16084RTR1-typeAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    GeneTreeiENSGT00390000017965.
    HOGENOMiHOG000253960.
    OMAiIIFRTSC.
    OrthoDBiEOG7XWPQD.
    TreeFamiTF331431.

    Family and domain databases

    InterProiIPR007308. DUF408.
    [Graphical view]
    PfamiPF04181. RPAP2_Rtr1. 1 hit.
    [Graphical view]
    PROSITEiPS51479. ZF_RTR1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    F6RRD7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADWVGPCSA GRKARRSRAS RDVAGTKQTS ALNQEDASQR KAELEAAVRK    50
    KIEFERKALH IVEQLLEENI SEEFLRECGK FITPAHYSDV VDERSIIKLC 100
    GYPLCQNKLG IVPKQKYKIS TKTNKVYDIT ERKCFCSNFC YKASKFFEAQ 150
    IPKSPVWIRE EERHPDFQLL QDGQSGPSGE EIQLCSKAIK TSDIDSPGHF 200
    EKHYESSSSS SHSDSSSDNE QDFVSSILPG NRPNATRPQL HEKSIMKKKA 250
    GQKVNSQHES KEQTVVDVIE QLGNCRLDNQ EKATACELPL QNVNTQISSN 300
    SSLQKKLEAS EISDIKYSSS KVTLVGISKK SAEHFKRKFA KSNQVSGSAS 350
    SSLQVCPEIA KANLLKALKE TLIEWKTEET LRFLYGQNYA SVCLKSSSTP 400
    LVKEEELDED DMNSDPDSHS PALQELNSLD ESLPFRASDT AIKPLPSYEN 450
    LKKETETLNL RIREFYRGRY VLNEETTKSQ DSEEHDPTFP LIDSSSQNQI 500
    RKRIVLEKLN KVLPGLLGPL QITLGDIYTQ LKNLVHTFRL TNRNIIHKPA 550
    EWTLIALVLL SILTSTLGIQ KLSQENVMFT QFMTTLLEEL HLKNEDLESL 600
    TIIFRTSC 608
    Length:608
    Mass (Da):68,698
    Last modified:November 16, 2011 - v1
    Checksum:i04EE1D88C5404049
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331N → I in AAI23868. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02007907 Genomic DNA. No translation available.
    BC123867 mRNA. Translation: AAI23868.1.
    RefSeqiNP_001096736.1. NM_001103266.1.
    XP_005204350.1. XM_005204293.1.
    XP_005204351.1. XM_005204294.1.
    XP_005204352.1. XM_005204295.1.
    UniGeneiBt.29255.

    Genome annotation databases

    EnsembliENSBTAT00000044283; ENSBTAP00000041791; ENSBTAG00000018739.
    GeneIDi529184.
    KEGGibta:529184.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02007907 Genomic DNA. No translation available.
    BC123867 mRNA. Translation: AAI23868.1 .
    RefSeqi NP_001096736.1. NM_001103266.1.
    XP_005204350.1. XM_005204293.1.
    XP_005204351.1. XM_005204294.1.
    XP_005204352.1. XM_005204295.1.
    UniGenei Bt.29255.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000041791.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000044283 ; ENSBTAP00000041791 ; ENSBTAG00000018739 .
    GeneIDi 529184.
    KEGGi bta:529184.

    Organism-specific databases

    CTDi 79871.

    Phylogenomic databases

    GeneTreei ENSGT00390000017965.
    HOGENOMi HOG000253960.
    OMAi IIFRTSC.
    OrthoDBi EOG7XWPQD.
    TreeFami TF331431.

    Miscellaneous databases

    NextBioi 20874979.

    Family and domain databases

    InterProi IPR007308. DUF408.
    [Graphical view ]
    Pfami PF04181. RPAP2_Rtr1. 1 hit.
    [Graphical view ]
    PROSITEi PS51479. ZF_RTR1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hereford.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Basal ganglia.

    Entry informationi

    Entry nameiRPAP2_BOVIN
    AccessioniPrimary (citable) accession number: F6RRD7
    Secondary accession number(s): A4FV88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2012
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3