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F6RRD7 (RPAP2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

EC=3.1.3.16
Alternative name(s):
RNA polymerase II-associated protein 2
Gene names
Name:RPAP2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length608 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner By similarity.

Sequence similarities

Belongs to the RPAP2 family.

Contains 1 RTR1-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 608607Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
PRO_0000416288

Regions

Zinc finger77 – 16084RTR1-type
Coiled coil33 – 6836 Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue4321Phosphoserine By similarity
Modified residue4791Phosphoserine By similarity

Experimental info

Sequence conflict331N → I in AAI23868. Ref.2

Sequences

Sequence LengthMass (Da)Tools
F6RRD7 [UniParc].

Last modified November 16, 2011. Version 1.
Checksum: 04EE1D88C5404049

FASTA60868,698
        10         20         30         40         50         60 
MADWVGPCSA GRKARRSRAS RDVAGTKQTS ALNQEDASQR KAELEAAVRK KIEFERKALH 

        70         80         90        100        110        120 
IVEQLLEENI SEEFLRECGK FITPAHYSDV VDERSIIKLC GYPLCQNKLG IVPKQKYKIS 

       130        140        150        160        170        180 
TKTNKVYDIT ERKCFCSNFC YKASKFFEAQ IPKSPVWIRE EERHPDFQLL QDGQSGPSGE 

       190        200        210        220        230        240 
EIQLCSKAIK TSDIDSPGHF EKHYESSSSS SHSDSSSDNE QDFVSSILPG NRPNATRPQL 

       250        260        270        280        290        300 
HEKSIMKKKA GQKVNSQHES KEQTVVDVIE QLGNCRLDNQ EKATACELPL QNVNTQISSN 

       310        320        330        340        350        360 
SSLQKKLEAS EISDIKYSSS KVTLVGISKK SAEHFKRKFA KSNQVSGSAS SSLQVCPEIA 

       370        380        390        400        410        420 
KANLLKALKE TLIEWKTEET LRFLYGQNYA SVCLKSSSTP LVKEEELDED DMNSDPDSHS 

       430        440        450        460        470        480 
PALQELNSLD ESLPFRASDT AIKPLPSYEN LKKETETLNL RIREFYRGRY VLNEETTKSQ 

       490        500        510        520        530        540 
DSEEHDPTFP LIDSSSQNQI RKRIVLEKLN KVLPGLLGPL QITLGDIYTQ LKNLVHTFRL 

       550        560        570        580        590        600 
TNRNIIHKPA EWTLIALVLL SILTSTLGIQ KLSQENVMFT QFMTTLLEEL HLKNEDLESL 


TIIFRTSC 

« Hide

References

[1]"A whole-genome assembly of the domestic cow, Bos taurus."
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.
Genome Biol. 10:R42.01-R42.10(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hereford.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Basal ganglia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DAAA02007907 Genomic DNA. No translation available.
BC123867 mRNA. Translation: AAI23868.1.
RefSeqNP_001096736.1. NM_001103266.1.
XP_005204350.1. XM_005204293.1.
XP_005204351.1. XM_005204294.1.
XP_005204352.1. XM_005204295.1.
UniGeneBt.29255.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000041791.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000044283; ENSBTAP00000041791; ENSBTAG00000018739.
GeneID529184.
KEGGbta:529184.

Organism-specific databases

CTD79871.

Phylogenomic databases

GeneTreeENSGT00390000017965.
HOGENOMHOG000253960.
OMAIIFRTSC.
OrthoDBEOG7XWPQD.
TreeFamTF331431.

Family and domain databases

InterProIPR007308. DUF408.
[Graphical view]
PfamPF04181. RPAP2_Rtr1. 1 hit.
[Graphical view]
PROSITEPS51479. ZF_RTR1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20874979.

Entry information

Entry nameRPAP2_BOVIN
AccessionPrimary (citable) accession number: F6RRD7
Secondary accession number(s): A4FV88
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: November 16, 2011
Last modified: April 16, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families