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Protein

Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

Gene

RPAP2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi100ZincPROSITE-ProRule annotation1
Metal bindingi105ZincPROSITE-ProRule annotation1
Metal bindingi136ZincPROSITE-ProRule annotation1
Metal bindingi140ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri77 – 160RTR1-typePROSITE-ProRule annotationAdd BLAST84

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC:3.1.3.16)
Alternative name(s):
RNA polymerase II-associated protein 2
Gene namesi
Name:RPAP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:34099 RPAP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00004162882 – 608Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei216PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei479PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiF6RRD7
PRIDEiF6RRD7

Expressioni

Gene expression databases

BgeeiENSBTAG00000018739

Interactioni

Subunit structurei

Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041791

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili33 – 68Sequence analysisAdd BLAST36

Sequence similaritiesi

Belongs to the RPAP2 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri77 – 160RTR1-typePROSITE-ProRule annotationAdd BLAST84

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG4780 Eukaryota
ENOG410ZZZC LUCA
GeneTreeiENSGT00390000017965
HOGENOMiHOG000253960
InParanoidiF6RRD7
KOiK20827
OMAiQYHISTR
OrthoDBiEOG091G0TLM
TreeFamiTF331431

Family and domain databases

Gene3Di1.25.40.820, 1 hit
InterProiView protein in InterPro
IPR007308 Rtr1/RPAP2
IPR038534 Rtr1/RPAP2_sf
PfamiView protein in Pfam
PF04181 RPAP2_Rtr1, 1 hit
PROSITEiView protein in PROSITE
PS51479 ZF_RTR1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

F6RRD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADWVGPCSA GRKARRSRAS RDVAGTKQTS ALNQEDASQR KAELEAAVRK
60 70 80 90 100
KIEFERKALH IVEQLLEENI SEEFLRECGK FITPAHYSDV VDERSIIKLC
110 120 130 140 150
GYPLCQNKLG IVPKQKYKIS TKTNKVYDIT ERKCFCSNFC YKASKFFEAQ
160 170 180 190 200
IPKSPVWIRE EERHPDFQLL QDGQSGPSGE EIQLCSKAIK TSDIDSPGHF
210 220 230 240 250
EKHYESSSSS SHSDSSSDNE QDFVSSILPG NRPNATRPQL HEKSIMKKKA
260 270 280 290 300
GQKVNSQHES KEQTVVDVIE QLGNCRLDNQ EKATACELPL QNVNTQISSN
310 320 330 340 350
SSLQKKLEAS EISDIKYSSS KVTLVGISKK SAEHFKRKFA KSNQVSGSAS
360 370 380 390 400
SSLQVCPEIA KANLLKALKE TLIEWKTEET LRFLYGQNYA SVCLKSSSTP
410 420 430 440 450
LVKEEELDED DMNSDPDSHS PALQELNSLD ESLPFRASDT AIKPLPSYEN
460 470 480 490 500
LKKETETLNL RIREFYRGRY VLNEETTKSQ DSEEHDPTFP LIDSSSQNQI
510 520 530 540 550
RKRIVLEKLN KVLPGLLGPL QITLGDIYTQ LKNLVHTFRL TNRNIIHKPA
560 570 580 590 600
EWTLIALVLL SILTSTLGIQ KLSQENVMFT QFMTTLLEEL HLKNEDLESL

TIIFRTSC
Length:608
Mass (Da):68,698
Last modified:November 16, 2011 - v1
Checksum:i04EE1D88C5404049
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33N → I in AAI23868 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02007907 Genomic DNA No translation available.
BC123867 mRNA Translation: AAI23868.1
RefSeqiNP_001096736.1, NM_001103266.1
XP_005204350.1, XM_005204293.3
XP_005204351.1, XM_005204294.3
XP_010801614.1, XM_010803312.2
XP_010801615.1, XM_010803313.2
UniGeneiBt.29255

Genome annotation databases

EnsembliENSBTAT00000044283; ENSBTAP00000041791; ENSBTAG00000018739
GeneIDi529184
KEGGibta:529184

Similar proteinsi

Entry informationi

Entry nameiRPAP2_BOVIN
AccessioniPrimary (citable) accession number: F6RRD7
Secondary accession number(s): A4FV88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: November 16, 2011
Last modified: May 23, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health