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F6RRD7

- RPAP2_BOVIN

UniProt

F6RRD7 - RPAP2_BOVIN

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Protein

Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

Gene
RPAP2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri77 – 16084RTR1-typeAdd
BLAST

GO - Molecular functioni

  1. CTD phosphatase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dephosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
  2. snRNA transcription Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC:3.1.3.16)
Alternative name(s):
RNA polymerase II-associated protein 2
Gene namesi
Name:RPAP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 3

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. DNA-directed RNA polymerase II, holoenzyme Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 608607Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2PRO_0000416288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei432 – 4321Phosphoserine By similarity
Modified residuei479 – 4791Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Interactioni

Subunit structurei

Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041791.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili33 – 6836 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the RPAP2 family.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri77 – 16084RTR1-typeAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00390000017965.
HOGENOMiHOG000253960.
OMAiIIFRTSC.
OrthoDBiEOG7XWPQD.
TreeFamiTF331431.

Family and domain databases

InterProiIPR007308. DUF408.
[Graphical view]
PfamiPF04181. RPAP2_Rtr1. 1 hit.
[Graphical view]
PROSITEiPS51479. ZF_RTR1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

F6RRD7-1 [UniParc]FASTAAdd to Basket

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MADWVGPCSA GRKARRSRAS RDVAGTKQTS ALNQEDASQR KAELEAAVRK    50
KIEFERKALH IVEQLLEENI SEEFLRECGK FITPAHYSDV VDERSIIKLC 100
GYPLCQNKLG IVPKQKYKIS TKTNKVYDIT ERKCFCSNFC YKASKFFEAQ 150
IPKSPVWIRE EERHPDFQLL QDGQSGPSGE EIQLCSKAIK TSDIDSPGHF 200
EKHYESSSSS SHSDSSSDNE QDFVSSILPG NRPNATRPQL HEKSIMKKKA 250
GQKVNSQHES KEQTVVDVIE QLGNCRLDNQ EKATACELPL QNVNTQISSN 300
SSLQKKLEAS EISDIKYSSS KVTLVGISKK SAEHFKRKFA KSNQVSGSAS 350
SSLQVCPEIA KANLLKALKE TLIEWKTEET LRFLYGQNYA SVCLKSSSTP 400
LVKEEELDED DMNSDPDSHS PALQELNSLD ESLPFRASDT AIKPLPSYEN 450
LKKETETLNL RIREFYRGRY VLNEETTKSQ DSEEHDPTFP LIDSSSQNQI 500
RKRIVLEKLN KVLPGLLGPL QITLGDIYTQ LKNLVHTFRL TNRNIIHKPA 550
EWTLIALVLL SILTSTLGIQ KLSQENVMFT QFMTTLLEEL HLKNEDLESL 600
TIIFRTSC 608
Length:608
Mass (Da):68,698
Last modified:November 16, 2011 - v1
Checksum:i04EE1D88C5404049
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331N → I in AAI23868. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02007907 Genomic DNA. No translation available.
BC123867 mRNA. Translation: AAI23868.1.
RefSeqiNP_001096736.1. NM_001103266.1.
XP_005204350.1. XM_005204293.1.
XP_005204351.1. XM_005204294.1.
XP_005204352.1. XM_005204295.1.
UniGeneiBt.29255.

Genome annotation databases

EnsembliENSBTAT00000044283; ENSBTAP00000041791; ENSBTAG00000018739.
GeneIDi529184.
KEGGibta:529184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02007907 Genomic DNA. No translation available.
BC123867 mRNA. Translation: AAI23868.1 .
RefSeqi NP_001096736.1. NM_001103266.1.
XP_005204350.1. XM_005204293.1.
XP_005204351.1. XM_005204294.1.
XP_005204352.1. XM_005204295.1.
UniGenei Bt.29255.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000041791.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000044283 ; ENSBTAP00000041791 ; ENSBTAG00000018739 .
GeneIDi 529184.
KEGGi bta:529184.

Organism-specific databases

CTDi 79871.

Phylogenomic databases

GeneTreei ENSGT00390000017965.
HOGENOMi HOG000253960.
OMAi IIFRTSC.
OrthoDBi EOG7XWPQD.
TreeFami TF331431.

Miscellaneous databases

NextBioi 20874979.

Family and domain databases

InterProi IPR007308. DUF408.
[Graphical view ]
Pfami PF04181. RPAP2_Rtr1. 1 hit.
[Graphical view ]
PROSITEi PS51479. ZF_RTR1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Basal ganglia.

Entry informationi

Entry nameiRPAP2_BOVIN
AccessioniPrimary (citable) accession number: F6RRD7
Secondary accession number(s): A4FV88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: November 16, 2011
Last modified: April 16, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi