Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribonuclease

Gene

Rnaseh2a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-DNA hybrid ribonuclease activity Source: MGI

GO - Biological processi

  1. DNA replication, removal of RNA primer Source: GO_Central
  2. mismatch repair Source: MGI
  3. RNA catabolic process Source: MGI
  4. RNA phosphodiester bond hydrolysis, endonucleolytic Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseUniRule annotation, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
RibonucleaseUniRule annotation (EC:3.1.26.-UniRule annotation)
Gene namesi
Name:Rnaseh2aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916974. Rnaseh2a.

Subcellular locationi

GO - Cellular componenti

  1. ribonuclease H2 complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiF6RP29.
ExpressionAtlasiF6RP29. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF6RP29.
SMRiF6RP29. Positions 27-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000010768.

Family and domain databases

Gene3Di1.10.10.460. 1 hit.
3.30.420.10. 1 hit.
InterProiIPR004649. RNase_H2_suA.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR023160. RNase_HII_hlx-loop-hlx_cap_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00729. TIGR00729. 1 hit.

Sequencei

Sequence statusi: Fragment.

F6RP29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SFRGKRALGP ALAVLFSTIV GCRRGSMDLS ELERDNTGRC RLSSPVPAVC
60 70 80 90 100
LKEPCVLGVD EAGRGPVLGP MVYAICYCPL SRLADLEALK VADSKTLTEN
110 120 130 140 150
ERERLFAKME EDGDFVGWAL DVLSPNLIST SMLGRVKYNL NSLSHDTAAG
160 170 180 190 200
LIQYALDQNV NVTQVFVDTV GMPETYQARL QQHFPGIEVT VKAKADSLFP
210 220 230 240 250
VVSAASIFAK VARDKAVKNW QFVENLQDLD SDYGSGYPND PKTKAWLRKH
260 270 280
VDPVFGFPQF VRFSWSTAQA ILEKEAEDVI WFVS
Length:284
Mass (Da):31,370
Last modified:July 27, 2011 - v1
Checksum:i55A8AD85FC4A3AAF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC163703 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000128972; ENSMUSP00000121864; ENSMUSG00000052926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC163703 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliF6RP29.
SMRiF6RP29. Positions 27-281.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000128972; ENSMUSP00000121864; ENSMUSG00000052926.

Organism-specific databases

MGIiMGI:1916974. Rnaseh2a.

Phylogenomic databases

GeneTreeiENSGT00390000010768.

Miscellaneous databases

ChiTaRSiRnaseh2a. mouse.
NextBioi35556789.
SOURCEiSearch...

Gene expression databases

BgeeiF6RP29.
ExpressionAtlasiF6RP29. baseline and differential.

Family and domain databases

Gene3Di1.10.10.460. 1 hit.
3.30.420.10. 1 hit.
InterProiIPR004649. RNase_H2_suA.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR023160. RNase_HII_hlx-loop-hlx_cap_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00729. TIGR00729. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF6RP29_MOUSE
AccessioniPrimary (citable) accession number: F6RP29
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 29, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.