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Protein
Submitted name:

Collagen alpha-3(IV) chain

Gene

Col4a3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Collagen alpha-3(IV) chainImported
Gene namesi
Name:Col4a3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104688 Col4a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membranePROSITE-ProRule annotation, Extracellular matrix, Secreted

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 74PROSITE-ProRule annotation

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.PROSITE-ProRule annotation
Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

MaxQBiF6RIS8
PeptideAtlasiF6RIS8

Expressioni

Gene expression databases

BgeeiENSMUSG00000079465
ExpressionAtlasiF6RIS8 baseline and differential

Structurei

3D structure databases

SMRiF6RIS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 150Collagen IV NC1InterPro annotationAdd BLAST143

Domaini

Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the type IV collagen family.PROSITE-ProRule annotation

Keywords - Domaini

CollagenPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140804

Family and domain databases

Gene3Di2.170.240.10, 1 hit
InterProiView protein in InterPro
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF01413 C4, 2 hits
SMARTiView protein in SMART
SM00111 C4, 1 hit
SUPFAMiSSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS51403 NC1_IV, 1 hit

Sequencei

Sequence statusi: Fragment.

F6RIS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ATGTRMRGFI FTRHSQTTAI PSCPEGTQPL YSGFSLLFVQ GNKRAHGQDL
60 70 80 90 100
GTLGSCLQRF TTMPFLFCNI NNVCNFASRN DYSYWLSTPA LMPMDMAPIS
110 120 130 140 150
GRALEPYISR CTVCEGPAMA IAVHSQTTAI PPCPQDWVSL WKGFSFIMKT
160 170 180 190
YSINCESWRL RENHKPLSGV HEEKTLTKSK KPEPFFFFFF FFLFLLK
Length:197
Mass (Da):22,381
Last modified:July 27, 2011 - v1
Checksum:i0EEA01E6BA6E5AAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC123746 Genomic DNA No translation available.
AC138214 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000152664; ENSMUSP00000119094; ENSMUSG00000079465

Similar proteinsi

Entry informationi

Entry nameiF6RIS8_MOUSE
AccessioniPrimary (citable) accession number: F6RIS8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health