Neurexin-1-beta - Mus musculus (Mouse)

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F6RHI8 (F6RHI8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 18. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Neurexin-1-beta Ensembl ENSMUSP00000072458

Gene names

Name:

Nrxn1 Ensembl ENSMUSP00000072458 MGI 1096391

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000072458

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1496 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000072458

Ontologies

Keywords
Cellular component	Membrane
Domain	EGF-like domain SAAS SAAS000152 RuleBase RU000460 Transmembrane Transmembrane helix SAAS SAAS003585
PTM	Disulfide bond SAAS SAAS000152 SAAS SAAS001791
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neurotransmitter secretion Inferred from genetic interaction PubMed 12827191. Source: MGI positive regulation of synapse assembly Inferred from genetic interaction PubMed 21356198. Source: MGI positive regulation of synapse maturation Inferred from direct assay PubMed 19567877. Source: MGI synapse assembly Inferred from genetic interaction PubMed 12827191. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW presynaptic membrane Inferred from direct assay PubMed 12827191. Source: MGI
Molecular_function	acetylcholine receptor binding Inferred from direct assay PubMed 19567877. Source: MGI calcium channel regulator activity Inferred from genetic interaction PubMed 12827191. Source: MGI
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

F6RHI8 [UniParc].

Last modified November 16, 2011. Version 2.
Checksum: 7927795160A5DFA2
Show »

FASTA

1,496

164,369

        10         20         30         40         50         60 
MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT 

        70         80         90        100        110        120 
RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR 

       130        140        150        160        170        180 
RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF 

       190        200        210        220        230        240 
KGWIRDVRVN SSQALPVDGG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ 

       250        260        270        280        290        300 
AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 

       310        320        330        340        350        360 
IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG 

       370        380        390        400        410        420 
KFNDNAWHDV KVTRNLRQVT ISVDGILTTT GYTQEDYTML GSDDFFYVGG SPSTADLPGS 

       430        440        450        460        470        480 
PVSNNFMGCL KEVVYKNNDV RLELSRLAKQ GDPKMKIHGV VAFKCENVAT LDPITFETPE 

       490        500        510        520        530        540 
SFISLPKWNA KKTGSISFDF RTTEPNGLIL FSHGKPRHQK DAKHPQMIKV DFFAIEMLDG 

       550        560        570        580        590        600 
HLYLLLDMGS GTIKIKALQK KVNDGEWYHV DFQRDGRSGT ISVNTLRTPY TAPGESEILD 

       610        620        630        640        650        660 
LDDELYLGGL PENKAGLVFP TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ MAEIQSTAGV 

       670        680        690        700        710        720 
KPSCSKETAK PCLSNPCKNN GMCRDGWNRY VCDCSGTGYL GRSCEREATV LSYDGSMFMK 

       730        740        750        760        770        780 
IQLPVVMHTE AEDVSLRFRS QRAYGILMAT TSRDSADTLR LELDAGRVKL TVNLDCIRIN 

       790        800        810        820        830        840 
CNSSKGPETL FAGYNLNDNE WHTVRVVRRG KSLKLTVDDQ QAMTGQMAGD HTRLEFHNIE 

       850        860        870        880        890        900 
TGIITERRYL SSVPSNFIGH LQSLTFNGMA YIDLCKNGDI DYCELNARFG FRNIIADPVT 

       910        920        930        940        950        960 
FKTKSSYVAL ATLQAYTSMH LFFQFKTTSL DGLILYNSGD GNDFIVVELV KGYLHYVFDL 

       970        980        990       1000       1010       1020 
GNGANLIKGS SNKPLNDNQW HNVMISRDTS NLHTVKIDTK ITTQITAGAR NLDLKSDLYI 

      1030       1040       1050       1060       1070       1080 
GGVAKETYKS LPKLVHAKEG FQGCLASVDL NGRLPDLISD ALFCNGQIER GCEGPSTTCQ 

      1090       1100       1110       1120       1130       1140 
EDSCSNQGVC LQQWDGFSCD CSMTSFSGPL CNDPGTTYIF SKGGGQITYK WPPNDRPSTR 

      1150       1160       1170       1180       1190       1200 
ADRLAIGFST VQKEAVLVRV DSSSGLGDYL ELHIHQGKIG VKFNVGTDDI AIEESNAIIN 

      1210       1220       1230       1240       1250       1260 
DGKYHVVRFT RSGGNATLQV DSWPVIERYP AGNNDNERLA IARQRIPYRL GRVVDEWLLD 

      1270       1280       1290       1300       1310       1320 
KGRQLTIFNS QATIIIGGKE QGQPFQGQLS GLYYNGLKVL NMAAENDANI AIVGNVRLVG 

      1330       1340       1350       1360       1370       1380 
EVPSSMTTES TATAMQSEMS TSIMETTTTL ATSTARRGKP PTKEPISQTT DDILVASAEC 

      1390       1400       1410       1420       1430       1440 
PSDDEDIDPC EPSSANPTRV GGREPYPGSA EVIRESSSTT GMVVGIVAAA ALCILILLYA 

      1450       1460       1470       1480       1490 
MYKYRNRDEG SYHVDESRNY ISNSAQSNGA VVKEKQPSSA KSANKNKKNK DKEYYV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000072458.
[2]	Ensembl Submitted (JUN-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000072458.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC101872 Genomic DNA. No translation available. AC131326 Genomic DNA. No translation available. AC151286 Genomic DNA. No translation available. AC154325 Genomic DNA. No translation available. AC154599 Genomic DNA. No translation available. AC167814 Genomic DNA. No translation available. AC170901 Genomic DNA. No translation available. AC171209 Genomic DNA. No translation available. CT025708 Genomic DNA. No translation available. CT486002 Genomic DNA. No translation available.
IPI	IPI01026671.
3D structure databases
ProteinModelPortal	F6RHI8.
SMR	F6RHI8. Positions 56-1320.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000072671; ENSMUSP00000072458; ENSMUSG00000024109.
Organism-specific databases
MGI	MGI:1096391. Nrxn1.
Phylogenomic databases
GeneTree	ENSGT00560000076996.
Gene expression databases
ArrayExpress	F6RHI8.
Bgee	F6RHI8.
Family and domain databases
Gene3D	2.60.120.200. 6 hits.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000742. EG-like_dom. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR001791. Laminin_G. IPR003585. Neurexin-like. IPR027158. NRXN1-alpha. [Graphical view]
PANTHER	PTHR10127:SF309. PTHR10127:SF309. 1 hit.
Pfam	PF02210. Laminin_G_2. 6 hits. [Graphical view]
SMART	SM00294. 4.1m. 1 hit. SM00181. EGF. 3 hits. SM00282. LamG. 6 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 6 hits.
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. PS50026. EGF_3. 3 hits. PS50025. LAM_G_DOMAIN. 6 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NRXN1. mouse.
NextBio	35556740.
SOURCE	Search...

Entry information

Entry name

F6RHI8_MOUSE

Accession

Primary (citable) accession number: F6RHI8

Entry history

Integrated into UniProtKB/TrEMBL:	July 27, 2011
Last sequence update:	November 16, 2011
Last modified:	May 1, 2013
This is version 18 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information