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F6RHI8

- F6RHI8_MOUSE

UniProt

F6RHI8 - F6RHI8_MOUSE

Protein
Submitted name:

Neurexin-1

Gene

Nrxn1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 2 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. acetylcholine receptor binding Source: MGI
    2. calcium channel regulator activity Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. neurotransmitter secretion Source: MGI
    2. positive regulation of synapse assembly Source: MGI
    3. positive regulation of synapse maturation Source: MGI
    4. regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
    5. synapse assembly Source: MGI
    6. synaptic transmission Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Neurexin-1Imported
    Gene namesi
    Name:Nrxn1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1096391. Nrxn1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. presynaptic membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    BgeeiF6RHI8.

    Structurei

    3D structure databases

    ProteinModelPortaliF6RHI8.
    SMRiF6RHI8. Positions 56-891, 896-1320.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    EGF-like domainUniRule annotationSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117263.
    KOiK07377.

    Family and domain databases

    Gene3Di2.60.120.200. 6 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR001791. Laminin_G.
    IPR003585. Neurexin-like.
    IPR027789. Syndecan/Neurexin_dom.
    [Graphical view]
    PfamiPF02210. Laminin_G_2. 6 hits.
    PF01034. Syndecan. 1 hit.
    [Graphical view]
    SMARTiSM00294. 4.1m. 1 hit.
    SM00181. EGF. 3 hits.
    SM00282. LamG. 6 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 7 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
    PS50026. EGF_3. 3 hits.
    PS50025. LAM_G_DOMAIN. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6RHI8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC     50
    ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP 100
    ATLLADTPVN DGAWHSVRIR RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF 150
    SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSQALPVDGG 200
    EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF 250
    RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 300
    IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA 350
    FEALVEPVNG KFNDNAWHDV KVTRNLRQVT ISVDGILTTT GYTQEDYTML 400
    GSDDFFYVGG SPSTADLPGS PVSNNFMGCL KEVVYKNNDV RLELSRLAKQ 450
    GDPKMKIHGV VAFKCENVAT LDPITFETPE SFISLPKWNA KKTGSISFDF 500
    RTTEPNGLIL FSHGKPRHQK DAKHPQMIKV DFFAIEMLDG HLYLLLDMGS 550
    GTIKIKALQK KVNDGEWYHV DFQRDGRSGT ISVNTLRTPY TAPGESEILD 600
    LDDELYLGGL PENKAGLVFP TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ 650
    MAEIQSTAGV KPSCSKETAK PCLSNPCKNN GMCRDGWNRY VCDCSGTGYL 700
    GRSCEREATV LSYDGSMFMK IQLPVVMHTE AEDVSLRFRS QRAYGILMAT 750
    TSRDSADTLR LELDAGRVKL TVNLDCIRIN CNSSKGPETL FAGYNLNDNE 800
    WHTVRVVRRG KSLKLTVDDQ QAMTGQMAGD HTRLEFHNIE TGIITERRYL 850
    SSVPSNFIGH LQSLTFNGMA YIDLCKNGDI DYCELNARFG FRNIIADPVT 900
    FKTKSSYVAL ATLQAYTSMH LFFQFKTTSL DGLILYNSGD GNDFIVVELV 950
    KGYLHYVFDL GNGANLIKGS SNKPLNDNQW HNVMISRDTS NLHTVKIDTK 1000
    ITTQITAGAR NLDLKSDLYI GGVAKETYKS LPKLVHAKEG FQGCLASVDL 1050
    NGRLPDLISD ALFCNGQIER GCEGPSTTCQ EDSCSNQGVC LQQWDGFSCD 1100
    CSMTSFSGPL CNDPGTTYIF SKGGGQITYK WPPNDRPSTR ADRLAIGFST 1150
    VQKEAVLVRV DSSSGLGDYL ELHIHQGKIG VKFNVGTDDI AIEESNAIIN 1200
    DGKYHVVRFT RSGGNATLQV DSWPVIERYP AGNNDNERLA IARQRIPYRL 1250
    GRVVDEWLLD KGRQLTIFNS QATIIIGGKE QGQPFQGQLS GLYYNGLKVL 1300
    NMAAENDANI AIVGNVRLVG EVPSSMTTES TATAMQSEMS TSIMETTTTL 1350
    ATSTARRGKP PTKEPISQTT DDILVASAEC PSDDEDIDPC EPSSANPTRV 1400
    GGREPYPGSA EVIRESSSTT GMVVGIVAAA ALCILILLYA MYKYRNRDEG 1450
    SYHVDESRNY ISNSAQSNGA VVKEKQPSSA KSANKNKKNK DKEYYV 1496
    Length:1,496
    Mass (Da):164,369
    Last modified:November 16, 2011 - v2
    Checksum:i7927795160A5DFA2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC101872 Genomic DNA. No translation available.
    AC131326 Genomic DNA. No translation available.
    AC151286 Genomic DNA. No translation available.
    AC154325 Genomic DNA. No translation available.
    AC154599 Genomic DNA. No translation available.
    AC167814 Genomic DNA. No translation available.
    AC170901 Genomic DNA. No translation available.
    AC171209 Genomic DNA. No translation available.
    CT025708 Genomic DNA. No translation available.
    CT486002 Genomic DNA. No translation available.
    RefSeqiXP_006523875.1. XM_006523812.1.
    UniGeneiMm.491332.

    Genome annotation databases

    EnsembliENSMUST00000072671; ENSMUSP00000072458; ENSMUSG00000024109.
    GeneIDi18189.
    KEGGimmu:18189.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC101872 Genomic DNA. No translation available.
    AC131326 Genomic DNA. No translation available.
    AC151286 Genomic DNA. No translation available.
    AC154325 Genomic DNA. No translation available.
    AC154599 Genomic DNA. No translation available.
    AC167814 Genomic DNA. No translation available.
    AC170901 Genomic DNA. No translation available.
    AC171209 Genomic DNA. No translation available.
    CT025708 Genomic DNA. No translation available.
    CT486002 Genomic DNA. No translation available.
    RefSeqi XP_006523875.1. XM_006523812.1.
    UniGenei Mm.491332.

    3D structure databases

    ProteinModelPortali F6RHI8.
    SMRi F6RHI8. Positions 56-891, 896-1320.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072671 ; ENSMUSP00000072458 ; ENSMUSG00000024109 .
    GeneIDi 18189.
    KEGGi mmu:18189.

    Organism-specific databases

    CTDi 9378.
    MGIi MGI:1096391. Nrxn1.

    Phylogenomic databases

    GeneTreei ENSGT00750000117263.
    KOi K07377.

    Miscellaneous databases

    ChiTaRSi NRXN1. mouse.
    NextBioi 35556740.
    SOURCEi Search...

    Gene expression databases

    Bgeei F6RHI8.

    Family and domain databases

    Gene3Di 2.60.120.200. 6 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR001791. Laminin_G.
    IPR003585. Neurexin-like.
    IPR027789. Syndecan/Neurexin_dom.
    [Graphical view ]
    Pfami PF02210. Laminin_G_2. 6 hits.
    PF01034. Syndecan. 1 hit.
    [Graphical view ]
    SMARTi SM00294. 4.1m. 1 hit.
    SM00181. EGF. 3 hits.
    SM00282. LamG. 6 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 7 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
    PS50026. EGF_3. 3 hits.
    PS50025. LAM_G_DOMAIN. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (JUN-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiF6RHI8_MOUSE
    AccessioniPrimary (citable) accession number: F6RHI8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3