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F6RHI8

- F6RHI8_MOUSE

UniProt

F6RHI8 - F6RHI8_MOUSE

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Protein
Submitted name:

Neurexin-1

Gene
Nrxn1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. acetylcholine receptor binding Source: MGI
  2. calcium channel regulator activity Source: MGI
  3. protein binding Source: MGI

GO - Biological processi

  1. neurotransmitter secretion Source: MGI
  2. positive regulation of synapse assembly Source: MGI
  3. positive regulation of synapse maturation Source: MGI
  4. regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  5. synapse assembly Source: MGI
  6. synaptic transmission Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neurexin-1Imported
Gene namesi
Name:Nrxn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1096391. Nrxn1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. presynaptic membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Expressioni

Gene expression databases

BgeeiF6RHI8.

Structurei

3D structure databases

ProteinModelPortaliF6RHI8.
SMRiF6RHI8. Positions 56-1320.

Family & Domainsi

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotations, Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117263.
KOiK07377.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PfamiPF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6RHI8-1 [UniParc]FASTAAdd to Basket

« Hide

MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC     50
ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP 100
ATLLADTPVN DGAWHSVRIR RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF 150
SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSQALPVDGG 200
EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF 250
RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP 300
IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA 350
FEALVEPVNG KFNDNAWHDV KVTRNLRQVT ISVDGILTTT GYTQEDYTML 400
GSDDFFYVGG SPSTADLPGS PVSNNFMGCL KEVVYKNNDV RLELSRLAKQ 450
GDPKMKIHGV VAFKCENVAT LDPITFETPE SFISLPKWNA KKTGSISFDF 500
RTTEPNGLIL FSHGKPRHQK DAKHPQMIKV DFFAIEMLDG HLYLLLDMGS 550
GTIKIKALQK KVNDGEWYHV DFQRDGRSGT ISVNTLRTPY TAPGESEILD 600
LDDELYLGGL PENKAGLVFP TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ 650
MAEIQSTAGV KPSCSKETAK PCLSNPCKNN GMCRDGWNRY VCDCSGTGYL 700
GRSCEREATV LSYDGSMFMK IQLPVVMHTE AEDVSLRFRS QRAYGILMAT 750
TSRDSADTLR LELDAGRVKL TVNLDCIRIN CNSSKGPETL FAGYNLNDNE 800
WHTVRVVRRG KSLKLTVDDQ QAMTGQMAGD HTRLEFHNIE TGIITERRYL 850
SSVPSNFIGH LQSLTFNGMA YIDLCKNGDI DYCELNARFG FRNIIADPVT 900
FKTKSSYVAL ATLQAYTSMH LFFQFKTTSL DGLILYNSGD GNDFIVVELV 950
KGYLHYVFDL GNGANLIKGS SNKPLNDNQW HNVMISRDTS NLHTVKIDTK 1000
ITTQITAGAR NLDLKSDLYI GGVAKETYKS LPKLVHAKEG FQGCLASVDL 1050
NGRLPDLISD ALFCNGQIER GCEGPSTTCQ EDSCSNQGVC LQQWDGFSCD 1100
CSMTSFSGPL CNDPGTTYIF SKGGGQITYK WPPNDRPSTR ADRLAIGFST 1150
VQKEAVLVRV DSSSGLGDYL ELHIHQGKIG VKFNVGTDDI AIEESNAIIN 1200
DGKYHVVRFT RSGGNATLQV DSWPVIERYP AGNNDNERLA IARQRIPYRL 1250
GRVVDEWLLD KGRQLTIFNS QATIIIGGKE QGQPFQGQLS GLYYNGLKVL 1300
NMAAENDANI AIVGNVRLVG EVPSSMTTES TATAMQSEMS TSIMETTTTL 1350
ATSTARRGKP PTKEPISQTT DDILVASAEC PSDDEDIDPC EPSSANPTRV 1400
GGREPYPGSA EVIRESSSTT GMVVGIVAAA ALCILILLYA MYKYRNRDEG 1450
SYHVDESRNY ISNSAQSNGA VVKEKQPSSA KSANKNKKNK DKEYYV 1496
Length:1,496
Mass (Da):164,369
Last modified:November 16, 2011 - v2
Checksum:i7927795160A5DFA2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC101872 Genomic DNA. No translation available.
AC131326 Genomic DNA. No translation available.
AC151286 Genomic DNA. No translation available.
AC154325 Genomic DNA. No translation available.
AC154599 Genomic DNA. No translation available.
AC167814 Genomic DNA. No translation available.
AC170901 Genomic DNA. No translation available.
AC171209 Genomic DNA. No translation available.
CT025708 Genomic DNA. No translation available.
CT486002 Genomic DNA. No translation available.
RefSeqiXP_006523875.1. XM_006523812.1.
UniGeneiMm.491332.

Genome annotation databases

EnsembliENSMUST00000072671; ENSMUSP00000072458; ENSMUSG00000024109.
GeneIDi18189.
KEGGimmu:18189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC101872 Genomic DNA. No translation available.
AC131326 Genomic DNA. No translation available.
AC151286 Genomic DNA. No translation available.
AC154325 Genomic DNA. No translation available.
AC154599 Genomic DNA. No translation available.
AC167814 Genomic DNA. No translation available.
AC170901 Genomic DNA. No translation available.
AC171209 Genomic DNA. No translation available.
CT025708 Genomic DNA. No translation available.
CT486002 Genomic DNA. No translation available.
RefSeqi XP_006523875.1. XM_006523812.1.
UniGenei Mm.491332.

3D structure databases

ProteinModelPortali F6RHI8.
SMRi F6RHI8. Positions 56-1320.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072671 ; ENSMUSP00000072458 ; ENSMUSG00000024109 .
GeneIDi 18189.
KEGGi mmu:18189.

Organism-specific databases

CTDi 9378.
MGIi MGI:1096391. Nrxn1.

Phylogenomic databases

GeneTreei ENSGT00750000117263.
KOi K07377.

Miscellaneous databases

ChiTaRSi NRXN1. mouse.
NextBioi 35556740.
SOURCEi Search...

Gene expression databases

Bgeei F6RHI8.

Family and domain databases

Gene3Di 2.60.120.200. 6 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view ]
Pfami PF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 7 hits.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF6RHI8_MOUSE
AccessioniPrimary (citable) accession number: F6RHI8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: November 16, 2011
Last modified: June 11, 2014
This is version 27 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi