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F6RHI8

- F6RHI8_MOUSE

UniProt

F6RHI8 - F6RHI8_MOUSE

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Protein
Submitted name:

Neurexin-1

Gene

Nrxn1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. acetylcholine receptor binding Source: MGI
  2. calcium channel regulator activity Source: MGI

GO - Biological processi

  1. neurotransmitter secretion Source: MGI
  2. positive regulation of synapse assembly Source: MGI
  3. positive regulation of synapse maturation Source: MGI
  4. regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  5. synapse assembly Source: MGI
  6. synaptic transmission Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neurexin-1Imported
Gene namesi
Name:Nrxn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1096391. Nrxn1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. presynaptic membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiF6RHI8.
ExpressionAtlasiF6RHI8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF6RHI8.
SMRiF6RHI8. Positions 56-1320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118991.
KOiK07377.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PfamiPF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6RHI8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC
60 70 80 90 100
ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP
110 120 130 140 150
ATLLADTPVN DGAWHSVRIR RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF
160 170 180 190 200
SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSQALPVDGG
210 220 230 240 250
EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF
260 270 280 290 300
RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP
310 320 330 340 350
IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA
360 370 380 390 400
FEALVEPVNG KFNDNAWHDV KVTRNLRQVT ISVDGILTTT GYTQEDYTML
410 420 430 440 450
GSDDFFYVGG SPSTADLPGS PVSNNFMGCL KEVVYKNNDV RLELSRLAKQ
460 470 480 490 500
GDPKMKIHGV VAFKCENVAT LDPITFETPE SFISLPKWNA KKTGSISFDF
510 520 530 540 550
RTTEPNGLIL FSHGKPRHQK DAKHPQMIKV DFFAIEMLDG HLYLLLDMGS
560 570 580 590 600
GTIKIKALQK KVNDGEWYHV DFQRDGRSGT ISVNTLRTPY TAPGESEILD
610 620 630 640 650
LDDELYLGGL PENKAGLVFP TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ
660 670 680 690 700
MAEIQSTAGV KPSCSKETAK PCLSNPCKNN GMCRDGWNRY VCDCSGTGYL
710 720 730 740 750
GRSCEREATV LSYDGSMFMK IQLPVVMHTE AEDVSLRFRS QRAYGILMAT
760 770 780 790 800
TSRDSADTLR LELDAGRVKL TVNLDCIRIN CNSSKGPETL FAGYNLNDNE
810 820 830 840 850
WHTVRVVRRG KSLKLTVDDQ QAMTGQMAGD HTRLEFHNIE TGIITERRYL
860 870 880 890 900
SSVPSNFIGH LQSLTFNGMA YIDLCKNGDI DYCELNARFG FRNIIADPVT
910 920 930 940 950
FKTKSSYVAL ATLQAYTSMH LFFQFKTTSL DGLILYNSGD GNDFIVVELV
960 970 980 990 1000
KGYLHYVFDL GNGANLIKGS SNKPLNDNQW HNVMISRDTS NLHTVKIDTK
1010 1020 1030 1040 1050
ITTQITAGAR NLDLKSDLYI GGVAKETYKS LPKLVHAKEG FQGCLASVDL
1060 1070 1080 1090 1100
NGRLPDLISD ALFCNGQIER GCEGPSTTCQ EDSCSNQGVC LQQWDGFSCD
1110 1120 1130 1140 1150
CSMTSFSGPL CNDPGTTYIF SKGGGQITYK WPPNDRPSTR ADRLAIGFST
1160 1170 1180 1190 1200
VQKEAVLVRV DSSSGLGDYL ELHIHQGKIG VKFNVGTDDI AIEESNAIIN
1210 1220 1230 1240 1250
DGKYHVVRFT RSGGNATLQV DSWPVIERYP AGNNDNERLA IARQRIPYRL
1260 1270 1280 1290 1300
GRVVDEWLLD KGRQLTIFNS QATIIIGGKE QGQPFQGQLS GLYYNGLKVL
1310 1320 1330 1340 1350
NMAAENDANI AIVGNVRLVG EVPSSMTTES TATAMQSEMS TSIMETTTTL
1360 1370 1380 1390 1400
ATSTARRGKP PTKEPISQTT DDILVASAEC PSDDEDIDPC EPSSANPTRV
1410 1420 1430 1440 1450
GGREPYPGSA EVIRESSSTT GMVVGIVAAA ALCILILLYA MYKYRNRDEG
1460 1470 1480 1490
SYHVDESRNY ISNSAQSNGA VVKEKQPSSA KSANKNKKNK DKEYYV
Length:1,496
Mass (Da):164,369
Last modified:November 16, 2011 - v2
Checksum:i7927795160A5DFA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC101872 Genomic DNA. No translation available.
AC131326 Genomic DNA. No translation available.
AC151286 Genomic DNA. No translation available.
AC154325 Genomic DNA. No translation available.
AC154599 Genomic DNA. No translation available.
AC167814 Genomic DNA. No translation available.
AC170901 Genomic DNA. No translation available.
AC171209 Genomic DNA. No translation available.
CT025708 Genomic DNA. No translation available.
CT486002 Genomic DNA. No translation available.
RefSeqiXP_006523875.1. XM_006523812.1.
UniGeneiMm.491332.

Genome annotation databases

EnsembliENSMUST00000072671; ENSMUSP00000072458; ENSMUSG00000024109.
GeneIDi18189.
KEGGimmu:18189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC101872 Genomic DNA. No translation available.
AC131326 Genomic DNA. No translation available.
AC151286 Genomic DNA. No translation available.
AC154325 Genomic DNA. No translation available.
AC154599 Genomic DNA. No translation available.
AC167814 Genomic DNA. No translation available.
AC170901 Genomic DNA. No translation available.
AC171209 Genomic DNA. No translation available.
CT025708 Genomic DNA. No translation available.
CT486002 Genomic DNA. No translation available.
RefSeqi XP_006523875.1. XM_006523812.1.
UniGenei Mm.491332.

3D structure databases

ProteinModelPortali F6RHI8.
SMRi F6RHI8. Positions 56-1320.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072671 ; ENSMUSP00000072458 ; ENSMUSG00000024109 .
GeneIDi 18189.
KEGGi mmu:18189.

Organism-specific databases

CTDi 9378.
MGIi MGI:1096391. Nrxn1.

Phylogenomic databases

GeneTreei ENSGT00760000118991.
KOi K07377.

Miscellaneous databases

ChiTaRSi Nrxn1. mouse.
NextBioi 35556740.
SOURCEi Search...

Gene expression databases

Bgeei F6RHI8.
ExpressionAtlasi F6RHI8. baseline and differential.

Family and domain databases

Gene3Di 2.60.120.200. 6 hits.
InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view ]
Pfami PF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 7 hits.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF6RHI8_MOUSE
AccessioniPrimary (citable) accession number: F6RHI8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: November 16, 2011
Last modified: November 26, 2014
This is version 30 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3