casp3

Functionⁱ

GO - Molecular functionⁱ

cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: GO_Central

Complete GO annotation...

GO - Biological processⁱ

erythrocyte differentiation Source: GO_Central
execution phase of apoptosis Source: GO_Central
keratinocyte differentiation Source: GO_Central
neuron differentiation Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol proteaseSAAS annotation

Molecular function

Hydrolase, Protease, Thiol proteaseSAAS annotation

Enzyme and pathway databases

Reactomeⁱ	R-XTR-111465. Apoptotic cleavage of cellular proteins. R-XTR-2028269. Signaling by Hippo. R-XTR-211227. Activation of DNA fragmentation factor. R-XTR-264870. Caspase-mediated cleavage of cytoskeletal proteins. R-XTR-351906. Apoptotic cleavage of cell adhesion proteins. R-XTR-418889. Ligand-independent caspase activation via DCC. R-XTR-449836. Other interleukin signaling.

Reactomeⁱ

R-XTR-111465. Apoptotic cleavage of cellular proteins.
R-XTR-2028269. Signaling by Hippo.
R-XTR-211227. Activation of DNA fragmentation factor.
R-XTR-264870. Caspase-mediated cleavage of cytoskeletal proteins.
R-XTR-351906. Apoptotic cleavage of cell adhesion proteins.
R-XTR-418889. Ligand-independent caspase activation via DCC.
R-XTR-449836. Other interleukin signaling.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Uncharacterized proteinImported
Gene namesⁱ	Name:casp3Imported
Organismⁱ	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifierⁱ	8364 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana
Proteomesⁱ	UP000008143 Componentⁱ: Unassembled WGS sequence

Organism-specific databases

Xenbaseⁱ	XB-GENE-479960. casp3.

Xenbaseⁱ

XB-GENE-479960. casp3.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm Source: GO_Central

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	F6RF24.

PaxDbⁱ

F6RF24.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSXETG00000001537.

Bgeeⁱ

ENSXETG00000001537.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	8364.ENSXETP00000003217.

STRINGⁱ

8364.ENSXETP00000003217.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F6RF24.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	54 – 178	CASPASE_P20InterPro annotationAdd BLAST		125
Domainⁱ	194 – 288	CASPASE_P10InterPro annotationAdd BLAST		95

Sequence similaritiesⁱ

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3573. Eukaryota. ENOG410ZQIE. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118912.
InParanoidⁱ	F6RF24.
OMAⁱ	DGFYSWR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05YD.
TreeFamⁱ	TF102023.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00032. CASc. 1 hit.
InterProⁱ	View protein in InterPro IPR029030. Caspase-like_dom. IPR015470. Caspase_3. IPR033139. Caspase_cys_AS. IPR016129. Caspase_his_AS. IPR002138. Pept_C14_p10. IPR001309. Pept_C14_p20. IPR015917. Pept_C14A.
PANTHERⁱ	PTHR10454:SF178. PTHR10454:SF178. 1 hit.
PRINTSⁱ	PR00376. IL1BCENZYME.
SMARTⁱ	View protein in SMART SM00115. CASc. 1 hit.
SUPFAMⁱ	SSF52129. SSF52129. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

F6RF24-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEESHNGVQY GEDTADAKTY FTNQQISLQN CDIKDMEKKT KFAHLHKYRT 
        60         70         80         90        100
DYPEMGICLI INNKNFQSST NMGVRNGTDV DARKLHETFT GLGYKVKVCN 
       110        120        130        140        150
DQKSNDIFTL LKKMSEEDHS KRSSFVCAIL SHGEDGLVYG VDGPIQIKNL 
       160        170        180        190        200
TDLFRGDRCK TLVGKPKLFF IQACRGTDLD SGIETDSGSE PGEEIQRIPV 
       210        220        230        240        250
EADFLYAYST VPGYYSWRNT MNGSWFIQSL CEMIKLYGPH LELIQILTCV 
       260        270        280 
NHMVALEFES CSTQQAFHAK KQIPCVVSML TKAFYFLK

Length:288

Mass (Da):32,703

Last modified:July 27, 2011 - v1

Checksum:ⁱ14BC7057AB49583D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAMC01031932 Genomic DNA. No translation available. AAMC01031933 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_017946639.1. XM_018091150.1.
UniGeneⁱ	Str.11713.

Genome annotation databases

Ensemblⁱ	ENSXETT00000003217; ENSXETP00000003217; ENSXETG00000001537.
GeneIDⁱ	100151728.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAMC01031932 Genomic DNA. No translation available. AAMC01031933 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_017946639.1. XM_018091150.1.
UniGeneⁱ	Str.11713.

3D structure databases

ProteinModelPortalⁱ	F6RF24.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	8364.ENSXETP00000003217.

STRINGⁱ

8364.ENSXETP00000003217.

Proteomic databases

PaxDbⁱ	F6RF24.

PaxDbⁱ

F6RF24.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSXETT00000003217; ENSXETP00000003217; ENSXETG00000001537.
GeneIDⁱ	100151728.

Organism-specific databases

CTDⁱ	836.
Xenbaseⁱ	XB-GENE-479960. casp3.

Phylogenomic databases

eggNOGⁱ	KOG3573. Eukaryota. ENOG410ZQIE. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118912.
InParanoidⁱ	F6RF24.
OMAⁱ	DGFYSWR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05YD.
TreeFamⁱ	TF102023.

Enzyme and pathway databases

Reactomeⁱ	R-XTR-111465. Apoptotic cleavage of cellular proteins. R-XTR-2028269. Signaling by Hippo. R-XTR-211227. Activation of DNA fragmentation factor. R-XTR-264870. Caspase-mediated cleavage of cytoskeletal proteins. R-XTR-351906. Apoptotic cleavage of cell adhesion proteins. R-XTR-418889. Ligand-independent caspase activation via DCC. R-XTR-449836. Other interleukin signaling.

Reactomeⁱ

R-XTR-111465. Apoptotic cleavage of cellular proteins.
R-XTR-2028269. Signaling by Hippo.
R-XTR-211227. Activation of DNA fragmentation factor.
R-XTR-264870. Caspase-mediated cleavage of cytoskeletal proteins.
R-XTR-351906. Apoptotic cleavage of cell adhesion proteins.
R-XTR-418889. Ligand-independent caspase activation via DCC.
R-XTR-449836. Other interleukin signaling.

Gene expression databases

Bgeeⁱ	ENSXETG00000001537.

Bgeeⁱ

ENSXETG00000001537.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00032. CASc. 1 hit.
InterProⁱ	View protein in InterPro IPR029030. Caspase-like_dom. IPR015470. Caspase_3. IPR033139. Caspase_cys_AS. IPR016129. Caspase_his_AS. IPR002138. Pept_C14_p10. IPR001309. Pept_C14_p20. IPR015917. Pept_C14A.
PANTHERⁱ	PTHR10454:SF178. PTHR10454:SF178. 1 hit.
PRINTSⁱ	PR00376. IL1BCENZYME.
SMARTⁱ	View protein in SMART SM00115. CASc. 1 hit.
SUPFAMⁱ	SSF52129. SSF52129. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F6RF24_XENTR
Accessionⁱ	F6RF24Primary (citable) accession number: F6RF24
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 27, 2011
	Last sequence update:	July 27, 2011
	Last modified:	July 5, 2017
	This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - F6RF24 (F6RF24_XENTR)

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Uncharacterized protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ