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F6R9V6

- F6R9V6_MONDO

UniProt

F6R9V6 - F6R9V6_MONDO

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Protein
Submitted name:

Uncharacterized protein

Gene

WHSC1

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. histone-lysine N-methyltransferase activity Source: Ensembl
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. atrial septum primum morphogenesis Source: Ensembl
  2. atrial septum secundum morphogenesis Source: Ensembl
  3. bone development Source: Ensembl
  4. membranous septum morphogenesis Source: Ensembl
  5. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:WHSC1Imported
OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
Taxonomic identifieri13616 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
ProteomesiUP000002280: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. nuclear membrane Source: Ensembl
  2. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118855.
InParanoidiF6R9V6.
OMAiPSKGKMM.
OrthoDBiEOG7Z69BG.
TreeFamiTF329088.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
3.30.40.10. 3 hits.
InterProiIPR006560. AWS_dom.
IPR009071. HMG_box_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF00628. PHD. 2 hits.
PF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00398. HMG. 1 hit.
SM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00184. RING. 2 hits.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
SSF57903. SSF57903. 3 hits.
PROSITEiPS51215. AWS. 1 hit.
PS50118. HMG_BOX_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6R9V6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFSIRRNSP SLTQKIVSQL KMKQVPEILG NTNGKTQNCE VNRECSVFLS
60 70 80 90 100
KAQISTTLPE GVMQKFNGHE ALPFIPAEKL KDLTSRVFNG ESGAQDAKLR
110 120 130 140 150
FESQEIKGIG TPPHTTPIKN GSPEIKLKIT KTYMNGKPLF ESSICGDNGP
160 170 180 190 200
DVSQSEENEQ KLENKSRRNR KRSIKYDSLL EQGLVEAALV SKASSPSEKK
210 220 230 240 250
ILAKRESYPN INKEKDHLLK YNVGDLVWSK VSGYPWWPCM VSADPLLHSY
260 270 280 290 300
TKLKGQKKSA RQYHVQFFGD APERAWIFEK SLVSFEGEEQ FEKLCQESAK
310 320 330 340 350
QAPTKAEKIK LLKPISGKLR TQWEMGIIQA KEAVSMTVEE RKAKFTFVYV
360 370 380 390 400
RDRLHLNPQV AKEAGIAVDP LEEIEESSDM SEETAQNLKH KELGVPIKRR
410 420 430 440 450
RRSKLLSCTD NLESDSGPKN ITPQRAAEQA DSKRGLGSPV GRKKAAASTP
460 470 480 490 500
RSRKGDSGSQ FLVFCQKHRD EVVAEHPDAS SEEIEELLES QWNMLNEKQK
510 520 530 540 550
ARYNTKFAIV TSPKSEEDSG SSLKNIGDTK RKVFQDSPKR RSRSRSNLHG
560 570 580 590 600
KKRNNTKRTQ HPTEDFEVQE PPRKRLRMDK QNNRKRETSN DKATKTNSSK
610 620 630 640 650
VTETSSSLKN QSATKNLSDA CKPLKKRNRA SATESSTLAF SKSSSPSTSL
660 670 680 690 700
TENEISDGQG DEPSESPYES ADETQTEISI SSKKSERGTT AKKEYVCQLC
710 720 730 740 750
EKSGNLLLCE GPCYGAFHLS CLGLSRRPEG KFICSECTSG IHSCFVCKEK
760 770 780 790 800
KTEVKRCVVS QCGKFYHEAC VKKYHLTVFE SRGFRCPLHS CVSCHVTNPS
810 820 830 840 850
NPRSSKGKMM RCVRCPVAYH GGDGCLAAGC SVIASNNIVC TNHFTARKGK
860 870 880 890 900
SHHAHVNVSW CFVCSKGGSL LCCESCPAAF HPDCLNIEMP DGSWYCNDCR
910 920 930 940 950
AGKKLHFQDI IWVKLGNYRW WPAEVCHPKN VPPNIQKMKH EIGEFPVFFF
960 970 980 990 1000
GSKDYYWTHQ ARVFPYMEGD RGSRYQGIKG IGKVFKNALH EAEARFREIK
1010 1020 1030 1040 1050
LQREARETQE NERKPPPYKH IKVNKPCGKV QIYTADVSEI PKCNCKPTDE
1060 1070 1080 1090 1100
NPCGFDSECL NRMLMYECHP QVCPAGEQCQ NQCFTKRQYP ETKIIKTDGK
1110 1120 1130 1140 1150
GWGLVAKRDI KKGEFVNEYV GELIDEEECM ARIKYAHEND ITHFYMLTID
1160 1170 1180 1190 1200
KDRIIDAGPK GNYSRFMNHS CQPNCETLKW TVNGDTRVGL FAVCDIPAGT
1210 1220 1230 1240 1250
ELTFNYNLDC LGNEKTVCRC GASNCSGFLG DRPKNSAALS SEEKGKKTKK
1260 1270 1280 1290 1300
KTRRRRTKGE GKKESEDDCF RCGDGGQLVL CDRKCCTKAY HLSCLDLVKR
1310 1320 1330 1340 1350
PFGKWECPWH HCDVCGKPSV SFCHFCPNSF CKEHQDGTVF STTQDGRLCC
1360 1370 1380 1390
SEHDFGVESI RNPKTEKPFP EPTKLKPKRK KRRCWRRKTE CK
Length:1,392
Mass (Da):157,281
Last modified:January 9, 2013 - v2
Checksum:i7253C1785A0473F1
GO

Genome annotation databases

EnsembliENSMODT00000005237; ENSMODP00000005127; ENSMODG00000004162.

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMODT00000005237 ; ENSMODP00000005127 ; ENSMODG00000004162 .

Phylogenomic databases

GeneTreei ENSGT00760000118855.
InParanoidi F6R9V6.
OMAi PSKGKMM.
OrthoDBi EOG7Z69BG.
TreeFami TF329088.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
3.30.40.10. 3 hits.
InterProi IPR006560. AWS_dom.
IPR009071. HMG_box_dom.
IPR003616. Post-SET_dom.
IPR000313. PWWP_dom.
IPR001214. SET_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
PF00628. PHD. 2 hits.
PF00855. PWWP. 2 hits.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00398. HMG. 1 hit.
SM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00293. PWWP. 2 hits.
SM00184. RING. 2 hits.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
SSF57903. SSF57903. 3 hits.
PROSITEi PS51215. AWS. 1 hit.
PS50118. HMG_BOX_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50812. PWWP. 2 hits.
PS50280. SET. 1 hit.
PS01359. ZF_PHD_1. 2 hits.
PS50016. ZF_PHD_2. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences."
    Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.
    , Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., Samollow P.B., Lander E.S., Lindblad-Toh K.
    Nature 447:167-177(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF6R9V6_MONDO
AccessioniPrimary (citable) accession number: F6R9V6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: January 9, 2013
Last modified: November 26, 2014
This is version 28 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3