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F6R9V6

- F6R9V6_MONDO

UniProt

F6R9V6 - F6R9V6_MONDO

Protein
Submitted name:

Uncharacterized protein

Gene

WHSC1

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 2 (09 Jan 2013)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. histone-lysine N-methyltransferase activity Source: Ensembl
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. atrial septum primum morphogenesis Source: Ensembl
    2. atrial septum secundum morphogenesis Source: Ensembl
    3. bone development Source: Ensembl
    4. membranous septum morphogenesis Source: Ensembl
    5. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:WHSC1Imported
    OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
    Taxonomic identifieri13616 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
    ProteomesiUP000002280: Chromosome 5

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear membrane Source: Ensembl
    2. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.
    Contains 1 post-SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114921.
    OMAiPSKGKMM.
    OrthoDBiEOG7Z69BG.
    TreeFamiTF329088.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    3.30.40.10. 3 hits.
    InterProiIPR006560. AWS.
    IPR009071. HMG_box_dom.
    IPR003616. Post-SET_dom.
    IPR000313. PWWP_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    PF00628. PHD. 2 hits.
    PF00855. PWWP. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00570. AWS. 1 hit.
    SM00398. HMG. 1 hit.
    SM00249. PHD. 4 hits.
    SM00508. PostSET. 1 hit.
    SM00293. PWWP. 2 hits.
    SM00184. RING. 2 hits.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    SSF57903. SSF57903. 3 hits.
    PROSITEiPS51215. AWS. 1 hit.
    PS50118. HMG_BOX_2. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50812. PWWP. 2 hits.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 2 hits.
    PS50016. ZF_PHD_2. 2 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F6R9V6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNFSIRRNSP SLTQKIVSQL KMKQVPEILG NTNGKTQNCE VNRECSVFLS     50
    KAQISTTLPE GVMQKFNGHE ALPFIPAEKL KDLTSRVFNG ESGAQDAKLR 100
    FESQEIKGIG TPPHTTPIKN GSPEIKLKIT KTYMNGKPLF ESSICGDNGP 150
    DVSQSEENEQ KLENKSRRNR KRSIKYDSLL EQGLVEAALV SKASSPSEKK 200
    ILAKRESYPN INKEKDHLLK YNVGDLVWSK VSGYPWWPCM VSADPLLHSY 250
    TKLKGQKKSA RQYHVQFFGD APERAWIFEK SLVSFEGEEQ FEKLCQESAK 300
    QAPTKAEKIK LLKPISGKLR TQWEMGIIQA KEAVSMTVEE RKAKFTFVYV 350
    RDRLHLNPQV AKEAGIAVDP LEEIEESSDM SEETAQNLKH KELGVPIKRR 400
    RRSKLLSCTD NLESDSGPKN ITPQRAAEQA DSKRGLGSPV GRKKAAASTP 450
    RSRKGDSGSQ FLVFCQKHRD EVVAEHPDAS SEEIEELLES QWNMLNEKQK 500
    ARYNTKFAIV TSPKSEEDSG SSLKNIGDTK RKVFQDSPKR RSRSRSNLHG 550
    KKRNNTKRTQ HPTEDFEVQE PPRKRLRMDK QNNRKRETSN DKATKTNSSK 600
    VTETSSSLKN QSATKNLSDA CKPLKKRNRA SATESSTLAF SKSSSPSTSL 650
    TENEISDGQG DEPSESPYES ADETQTEISI SSKKSERGTT AKKEYVCQLC 700
    EKSGNLLLCE GPCYGAFHLS CLGLSRRPEG KFICSECTSG IHSCFVCKEK 750
    KTEVKRCVVS QCGKFYHEAC VKKYHLTVFE SRGFRCPLHS CVSCHVTNPS 800
    NPRSSKGKMM RCVRCPVAYH GGDGCLAAGC SVIASNNIVC TNHFTARKGK 850
    SHHAHVNVSW CFVCSKGGSL LCCESCPAAF HPDCLNIEMP DGSWYCNDCR 900
    AGKKLHFQDI IWVKLGNYRW WPAEVCHPKN VPPNIQKMKH EIGEFPVFFF 950
    GSKDYYWTHQ ARVFPYMEGD RGSRYQGIKG IGKVFKNALH EAEARFREIK 1000
    LQREARETQE NERKPPPYKH IKVNKPCGKV QIYTADVSEI PKCNCKPTDE 1050
    NPCGFDSECL NRMLMYECHP QVCPAGEQCQ NQCFTKRQYP ETKIIKTDGK 1100
    GWGLVAKRDI KKGEFVNEYV GELIDEEECM ARIKYAHEND ITHFYMLTID 1150
    KDRIIDAGPK GNYSRFMNHS CQPNCETLKW TVNGDTRVGL FAVCDIPAGT 1200
    ELTFNYNLDC LGNEKTVCRC GASNCSGFLG DRPKNSAALS SEEKGKKTKK 1250
    KTRRRRTKGE GKKESEDDCF RCGDGGQLVL CDRKCCTKAY HLSCLDLVKR 1300
    PFGKWECPWH HCDVCGKPSV SFCHFCPNSF CKEHQDGTVF STTQDGRLCC 1350
    SEHDFGVESI RNPKTEKPFP EPTKLKPKRK KRRCWRRKTE CK 1392
    Length:1,392
    Mass (Da):157,281
    Last modified:January 9, 2013 - v2
    Checksum:i7253C1785A0473F1
    GO

    Genome annotation databases

    EnsembliENSMODT00000005237; ENSMODP00000005127; ENSMODG00000004162.

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMODT00000005237 ; ENSMODP00000005127 ; ENSMODG00000004162 .

    Phylogenomic databases

    GeneTreei ENSGT00740000114921.
    OMAi PSKGKMM.
    OrthoDBi EOG7Z69BG.
    TreeFami TF329088.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    3.30.40.10. 3 hits.
    InterProi IPR006560. AWS.
    IPR009071. HMG_box_dom.
    IPR003616. Post-SET_dom.
    IPR000313. PWWP_dom.
    IPR001214. SET_dom.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    PF00628. PHD. 2 hits.
    PF00855. PWWP. 2 hits.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00570. AWS. 1 hit.
    SM00398. HMG. 1 hit.
    SM00249. PHD. 4 hits.
    SM00508. PostSET. 1 hit.
    SM00293. PWWP. 2 hits.
    SM00184. RING. 2 hits.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    SSF57903. SSF57903. 3 hits.
    PROSITEi PS51215. AWS. 1 hit.
    PS50118. HMG_BOX_2. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50812. PWWP. 2 hits.
    PS50280. SET. 1 hit.
    PS01359. ZF_PHD_1. 2 hits.
    PS50016. ZF_PHD_2. 2 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences."
      Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.
      , Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., Samollow P.B., Lander E.S., Lindblad-Toh K.
      Nature 447:167-177(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiF6R9V6_MONDO
    AccessioniPrimary (citable) accession number: F6R9V6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: January 9, 2013
    Last modified: October 1, 2014
    This is version 26 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3