ID   Q17R02_BOVIN            Unreviewed;       646 AA.
AC   Q17R02; F6QQ19;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   SubName: Full=Nuclear receptor binding SET domain protein 3 {ECO:0000313|Ensembl:ENSBTAP00000002006.5};
DE   SubName: Full=Wolf-Hirschhorn syndrome candidate 1-like 1 {ECO:0000313|EMBL:AAI18093.1};
GN   Name=NSD3 {ECO:0000313|Ensembl:ENSBTAP00000002006.5,
GN   ECO:0000313|VGNC:VGNC:32273};
GN   Synonyms=WHSC1L1 {ECO:0000313|EMBL:AAI18093.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI18093.1};
RN   [1] {ECO:0000313|EMBL:AAI18093.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI18093.1};
RC   TISSUE=Uterus {ECO:0000313|EMBL:AAI18093.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA   Holt R., Jones S.J., Marra M.A.;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000002006.5, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002006.5,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSBTAP00000002006.5}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002006.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; BC118092; AAI18093.1; -; mRNA.
DR   Ensembl; ENSBTAT00000002006.5; ENSBTAP00000002006.5; ENSBTAG00000001529.7.
DR   VEuPathDB; HostDB:ENSBTAG00000001529; -.
DR   VGNC; VGNC:32273; NSD3.
DR   GeneTree; ENSGT00940000155355; -.
DR   HOGENOM; CLU_488831_0_0_1; -.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000001529; Expressed in retropharyngeal lymph node and 107 other cell types or tissues.
DR   CDD; cd20163; PWWP_NSD3_rpt1; 1.
DR   Gene3D; 2.30.30.140; -; 1.
DR   InterPro; IPR000313; PWWP_dom.
DR   InterPro; IPR047451; PWWP_NSD3_rpt1.
DR   PANTHER; PTHR22884:SF473; HISTONE-LYSINE N-METHYLTRANSFERASE NSD3; 1.
DR   PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR   Pfam; PF00855; PWWP; 1.
DR   SMART; SM00293; PWWP; 1.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR   PROSITE; PS50812; PWWP; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN          271..334
FT                   /note="PWWP"
FT                   /evidence="ECO:0000259|PROSITE:PS50812"
FT   REGION          121..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          182..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          345..366
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          541..646
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..143
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..247
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..366
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        427..447
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        448..465
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        541..575
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        576..605
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        628..646
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   646 AA;  72735 MW;  3311EDE78AD14201 CRC64;
     MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ EDAFDNNSDI VEDGGQTPYE ATLQQGFQYP
     PTTEDLPPLT NGYPPSISMY ETQTKYQSYN QYPNGSANGF GTVRNFSPSD YYHSEIPNTR
     PHEILEKPSP PQPPPPPPSV PQTVIPKKTG SPEIKLKITK TIQNGRELFE SSLCGDLLNE
     VQASEHTKSK HESRKEKRKK SNKHDSSRSE ERKSHKIPKL EPEEQNRPNE RVDPVSEKPR
     EDPVLKEETP VQPMLPSVPT AEASAGVKFQ VGDLVWSKVG TYPWWPCMVS SDPQLEVHTK
     INTRGAREYH VQFFSNQPER AWVHEKRVRE YKGHKQYEEL LAEATRQASN HSEKQKIRKP
     RPQRERAQWD IGIAHAEKAL TMTREERIEQ YTFIYIDKQP EETLSQAKKN VVSKAEVKKP
     RRPRSVLNVQ PEQTNAGEAA SSPSGTEMRR HSQRRHTGVD EDEPPPVKVA WKTAAARKSL
     PASITMHKGS LDLQKCNMSP VVKIEQVFAL QNATGDGKFI DQFVYSTKGI GNKTEISVRG
     QDRLIISTPN QRNEKATQNM SSPEATSGSA GSVEKKQQRR SIRTRSESEK STEVVPKKKI
     KKEQVETVPQ ATVKTGLQKG SADRGVQGSV RFSDSSVSAA IEETVD
//