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Protein

Chloride channel protein

Gene

Clcn1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transportUniRule annotationSAAS annotation, Transport
LigandChlorideUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel proteinUniRule annotation
Gene namesi
Name:Clcn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:88417. Clcn1.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei89 – 110HelicalUniRule annotationAdd BLAST22
Transmembranei130 – 153HelicalUniRule annotationAdd BLAST24
Transmembranei174 – 194HelicalUniRule annotationAdd BLAST21
Transmembranei206 – 225HelicalUniRule annotationAdd BLAST20
Transmembranei237 – 262HelicalUniRule annotationAdd BLAST26
Transmembranei277 – 299HelicalUniRule annotationAdd BLAST23
Transmembranei320 – 339HelicalUniRule annotationAdd BLAST20
Transmembranei455 – 476HelicalUniRule annotationAdd BLAST22
Transmembranei483 – 502HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiF6QI82.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029862.
ExpressionAtlasiF6QI82. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini538 – 597CBSInterPro annotationAdd BLAST60
Domaini756 – 811CBSInterPro annotationAdd BLAST56

Sequence similaritiesi

Belongs to the chloride channel (TC 2.A.49) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

CBS domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0476. Eukaryota.
COG0038. LUCA.
GeneTreeiENSGT00760000119109.

Family and domain databases

Gene3Di1.10.3080.10. 2 hits.
InterProiView protein in InterPro
IPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002243. Cl_channel-1.
PfamiView protein in Pfam
PF00654. Voltage_CLC. 2 hits.
PRINTSiPR00762. CLCHANNEL.
PR01112. CLCHANNEL1.
SUPFAMiSSF81340. SSF81340. 1 hit.
PROSITEiView protein in PROSITE
PS51371. CBS. 2 hits.

Sequencei

Sequence statusi: Fragment.

F6QI82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XTSYGLPSEN GGLQHRPRKD MGPRHNAHPT QIYGHQKEQY SYKAQDGGMP
60 70 80 90 100
KKMGSSSTMD SLDEDHYSKC QDCVHRLGRV LRRKLGEDWI FLVLLGLLMA
110 120 130 140 150
LVSWCMDYVS AKSLQAYKWT YAQMKPSLPL QYLAWVTFPL ILILFSALFC
160 170 180 190 200
QLISPQAVGS GIPEMKTILR GVVLKEYLTL KAFVAKVVAL TAGLGSGIPV
210 220 230 240 250
GKEGPFVHIA SICAAVLSKF MSMFSGVYEQ PYYYTDILTV GCAVGVGCCF
260 270 280 290 300
GTPLGVTITA LFRTNFRMDF PFDLKELPAF AVIGICCGFL GAVFVYLHRQ
310 320 330 340 350
VMLGVRKHKC LSQFLAKHRL LYPGIVTFVI ASLTFPPGMG QFMAGELMPR
360 370 380 390 400
EAISTLFDNN TWVKHIGDPQ SLGQSAVWLH PQVNVIIIIL LFFVMKFWMS
410 420 430 440 450
IVATTMPIPC GGFMPVFVLG AAFGRLVGEI MAMLFPEGIL FDDIIYKILP
460 470 480 490 500
GGYAVIGAAA LTGAVSHTVS TAVICFELTG QIAHILPMMV AVILANMVAQ
510 520 530 540 550
SLQPSLYDSI IQVKKLPYLP DLGWNQLSKF TIFVEDIMVR DVKFVSASCT
560 570 580 590 600
YGELRNLLQA TTVKTLPLVD SKDSMILLGS VERSELQSLL QRHLCAERRL
610 620 630 640 650
KAAQDMARKL SELPYNGKAQ LAGDWHPGGR PESFAFVDED EDEDLSRKME
660 670 680 690 700
LPLTPAPPPP SPPPPPSQFP IAPSNPEEPN GPLPSHKQPP EASDSADQRS
710 720 730 740 750
STFQRLLHCL LGKAHSKKKK ITQDSTDLVD NMSPEEIEAW EREQLSQPVC
760 770 780 790 800
FDCCCIDQSP FQLVEQTTLH KTHTLFSLLG LHLAYVTSMG KLRGVLALEE
810 820 830 840 850
LQKAIEGHTK SGVQLRPPLA SFRNTTSIRK TPGGPPPPAE GWNVPEDGDG
860 870 880 890 900
APGREVMVPT MPETPVPPPS PEAPSCLAPA RAEGELEELE MVGSLEPEEE
910 920
LADILHGPSL RSTDEEDEDE LIL
Length:923
Mass (Da):101,457
Last modified:July 27, 2011 - v1
Checksum:i965FF723DB55F17F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC153915 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000163936; ENSMUSP00000130148; ENSMUSG00000029862.

Similar proteinsi

Entry informationi

Entry nameiF6QI82_MOUSE
AccessioniPrimary (citable) accession number: F6QI82
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: August 30, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported