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Protein
Submitted name:

Ribosomal protein S6 kinase alpha-1

Gene

Rps6ka1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ribosomal protein S6 kinase alpha-1Imported
Gene namesi
Name:Rps6ka1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:104558. Rps6ka1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiF6Q8A4.
PaxDbiF6Q8A4.

Expressioni

Gene expression databases

BgeeiF6Q8A4.
ExpressionAtlasiF6Q8A4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101514.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 327260Protein kinaseInterPro annotationAdd
BLAST
Domaini328 – 39770AGC-kinase C-terminalInterPro annotationAdd
BLAST
Domaini424 – 681258Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains AGC-kinase C-terminal domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126961.
OMAiPWITQKD.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016239. Ribosomal_S6_kinase_II.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000606. Ribsml_S6_kin_2. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

F6Q8A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQDPKLPRL RLRTLLPWLL GKQRSRISQT LPGPGPGPQQ DSDEAILKEI
60 70 80 90 100
SITHHVKAGS EKADPSQFEL LKVLGQGSFG KVFLVRKVTR PDSGHLYAMK
110 120 130 140 150
VLKKATLKVR DRVRTKMERD ILADVNHPFV VKLHYAFQTE GKLYLILDFL
160 170 180 190 200
RGGDLFTRLS KEVMFTEEDV KFYLAELALG LDHLHSLGII YRDLKPENIL
210 220 230 240 250
LDEEGHIKLT DFGLSKEAID HEKKAYSFCG TVEYMAPEVV NRQGHTHSAD
260 270 280 290 300
WWSYGVLMFE MLTGSLPFQG KDRKETMTLI LKAKLGMPQF LSTEAQSLLR
310 320 330 340 350
ALFKRNPANR LGSGPDGAEE IKRHIFYSTI DWNKLYRREI KPPFKPAVAQ
360 370 380 390 400
PDDTFYFDTE FTSRTPRDSP GIPPSAGAHQ LFRGFSFVAT GLMEDDGKPR
410 420 430 440 450
TTQAPLHSVV QQLHGKNLVF SDGYVVKETI GVGSYSVCKR CVHKATNMEY
460 470 480 490 500
AVKVIDKSKR DPSEEIEILL RYGQHPNIIT LKDVYDDGKH VYLVTELMRG
510 520 530 540 550
GELLDKILRQ KFFSEREASF VLHTISKTVE YLHSQGVVHR DLKPSNILYV
560 570 580 590 600
DESGNPECLR ICDFGFAKQL RAENGLLMTP CYTANFVAPE VLKRQGYDEG
610 620 630 640 650
CDIWSLGILL YTMLAGYTPF ANGPSDTPEE ILTRIGSGKF TLSGGNWNTV
660 670 680 690 700
SETAKDLVSK MLHVDPHQRL TAKQVLQHPW ITQKDKLPQS QLSHQDLQLV
710 720 730 740
KGAMAATYSA LNSSKPTPQL KPIESSILAQ RRVRKLPSTT L
Length:741
Mass (Da):83,677
Last modified:November 16, 2011 - v1
Checksum:iD30DA68327BFC5EC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei741 – 7411Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL837508 Genomic DNA. No translation available.
RefSeqiXP_006538740.1. XM_006538677.2.
UniGeneiMm.301827.

Genome annotation databases

EnsembliENSMUST00000137486; ENSMUSP00000119328; ENSMUSG00000003644.
GeneIDi20111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL837508 Genomic DNA. No translation available.
RefSeqiXP_006538740.1. XM_006538677.2.
UniGeneiMm.301827.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101514.

Proteomic databases

MaxQBiF6Q8A4.
PaxDbiF6Q8A4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000137486; ENSMUSP00000119328; ENSMUSG00000003644.
GeneIDi20111.

Organism-specific databases

CTDi6195.
MGIiMGI:104558. Rps6ka1.

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126961.
OMAiPWITQKD.

Miscellaneous databases

ChiTaRSiRps6ka1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiF6Q8A4.
ExpressionAtlasiF6Q8A4. baseline and differential.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016239. Ribosomal_S6_kinase_II.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000606. Ribsml_S6_kin_2. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF6Q8A4_MOUSE
AccessioniPrimary (citable) accession number: F6Q8A4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 8, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.