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Protein
Submitted name:

Ribosomal protein S6 kinase alpha-1

Gene

Rps6ka1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100ATPUniRule annotation1
Active sitei193Proton acceptorUniRule annotation1
Binding sitei453ATPUniRule annotation1
Active sitei541Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 82ATPUniRule annotation9
Nucleotide bindingi430 – 438ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ribosomal protein S6 kinase alpha-1Imported
Gene namesi
Name:Rps6ka1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:104558 Rps6ka1

Subcellular locationi

PTM / Processingi

Proteomic databases

MaxQBiF6Q8A4
PRIDEiF6Q8A4

Expressioni

Gene expression databases

BgeeiENSMUSG00000003644
ExpressionAtlasiF6Q8A4 baseline and differential

Structurei

3D structure databases

SMRiF6Q8A4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 327Protein kinaseInterPro annotationAdd BLAST260
Domaini328 – 397AGC-kinase C-terminalInterPro annotationAdd BLAST70
Domaini424 – 681Protein kinaseInterPro annotationAdd BLAST258

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00920000148962
OMAiPWITQKD
OrthoDBiEOG091G05Z7

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016239 Ribosomal_S6_kinase_II
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
PF00433 Pkinase_C, 1 hit
PIRSFiPIRSF000606 Ribsml_S6_kin_2, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 2 hits
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 2 hits
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00108 PROTEIN_KINASE_ST, 2 hits

Sequencei

Sequence statusi: Fragment.

F6Q8A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQDPKLPRL RLRTLLPWLL GKQRSRISQT LPGPGPGPQQ DSDEAILKEI
60 70 80 90 100
SITHHVKAGS EKADPSQFEL LKVLGQGSFG KVFLVRKVTR PDSGHLYAMK
110 120 130 140 150
VLKKATLKVR DRVRTKMERD ILADVNHPFV VKLHYAFQTE GKLYLILDFL
160 170 180 190 200
RGGDLFTRLS KEVMFTEEDV KFYLAELALG LDHLHSLGII YRDLKPENIL
210 220 230 240 250
LDEEGHIKLT DFGLSKEAID HEKKAYSFCG TVEYMAPEVV NRQGHTHSAD
260 270 280 290 300
WWSYGVLMFE MLTGSLPFQG KDRKETMTLI LKAKLGMPQF LSTEAQSLLR
310 320 330 340 350
ALFKRNPANR LGSGPDGAEE IKRHIFYSTI DWNKLYRREI KPPFKPAVAQ
360 370 380 390 400
PDDTFYFDTE FTSRTPRDSP GIPPSAGAHQ LFRGFSFVAT GLMEDDGKPR
410 420 430 440 450
TTQAPLHSVV QQLHGKNLVF SDGYVVKETI GVGSYSVCKR CVHKATNMEY
460 470 480 490 500
AVKVIDKSKR DPSEEIEILL RYGQHPNIIT LKDVYDDGKH VYLVTELMRG
510 520 530 540 550
GELLDKILRQ KFFSEREASF VLHTISKTVE YLHSQGVVHR DLKPSNILYV
560 570 580 590 600
DESGNPECLR ICDFGFAKQL RAENGLLMTP CYTANFVAPE VLKRQGYDEG
610 620 630 640 650
CDIWSLGILL YTMLAGYTPF ANGPSDTPEE ILTRIGSGKF TLSGGNWNTV
660 670 680 690 700
SETAKDLVSK MLHVDPHQRL TAKQVLQHPW ITQKDKLPQS QLSHQDLQLV
710 720 730 740
KGAMAATYSA LNSSKPTPQL KPIESSILAQ RRVRKLPSTT L
Length:741
Mass (Da):83,677
Last modified:November 16, 2011 - v1
Checksum:iD30DA68327BFC5EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei741Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL837508 Genomic DNA No translation available.
RefSeqiXP_006538740.1, XM_006538677.3
UniGeneiMm.301827

Genome annotation databases

EnsembliENSMUST00000137486; ENSMUSP00000119328; ENSMUSG00000003644
GeneIDi20111

Similar proteinsi

Entry informationi

Entry nameiF6Q8A4_MOUSE
AccessioniPrimary (citable) accession number: F6Q8A4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 20, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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