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F6MZK5

- F6MZK5_HUMAN

UniProt

F6MZK5 - F6MZK5_HUMAN

Protein
Submitted name:

Insulin

Gene

INS

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.SAAS annotation

    GO - Biological processi

    1. glucose metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    HormoneSAAS annotation

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolismSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    InsulinImported
    Gene namesi
    Name:INSImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Secreted UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    SecretedSAAS annotation

    Pathology & Biotechi

    Protein family/group databases

    Allergomei2121. Hom s Insulin.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei‹1 – 8›8 PotentialImported
    Chaini9 – ›94›86 PotentialImportedPRO_5000755530Add
    BLAST

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiF6MZK5.
    BgeeiF6MZK5.

    Interactioni

    Subunit structurei

    Heterodimer of a B chain and an A chain linked by two disulfide bonds.SAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the insulin family.UniRule annotation

    Keywords - Domaini

    SignalImported

    Family and domain databases

    Gene3Di1.10.100.10. 2 hits.
    InterProiIPR004825. Insulin.
    IPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF00049. Insulin. 1 hit.
    [Graphical view]
    PRINTSiPR00277. INSULIN.
    PR00276. INSULINFAMLY.
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    F6MZK5-1 [UniParc]FASTAAdd to Basket

    « Hide

    WGPDPAAAFV NQHLCGSHLV EALYLVCGER GFFYTPKTRR EAEDLQVGQV   50
    ELGGGPGAGS LQPLALEGSL QKRGIVEQCC TSICSLYQLE NYCN 94
    Length:94
    Mass (Da):10,160
    Last modified:July 27, 2011 - v1
    Checksum:i9D57C451E8E9469E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei94 – 941Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JF909299 mRNA. Translation: AEG19452.1.
    UniGeneiHs.272259.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JF909299 mRNA. Translation: AEG19452.1 .
    UniGenei Hs.272259.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 2121. Hom s Insulin.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    NextBioi 35510200.

    Gene expression databases

    ArrayExpressi F6MZK5.
    Bgeei F6MZK5.

    Family and domain databases

    Gene3Di 1.10.100.10. 2 hits.
    InterProi IPR004825. Insulin.
    IPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF00049. Insulin. 1 hit.
    [Graphical view ]
    PRINTSi PR00277. INSULIN.
    PR00276. INSULINFAMLY.
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Preparation of human insulin gene construct in order to use in diabetes mellitus gene therapy."
      Piri H., Kazemi B., Bandehpour M., Rezaei M., Goodarzi M.T., Khodadadi I., Hasanzadeh T., Sirati Sabet M., Tasa D., Heidari H.R., Karimi J., Yari Khosroshahi A., Eghdami A., Tavakkoli A.H.
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: PancreasImported.

    Entry informationi

    Entry nameiF6MZK5_HUMAN
    AccessioniPrimary (citable) accession number: F6MZK5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.