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F6MZK5

- F6MZK5_HUMAN

UniProt

F6MZK5 - F6MZK5_HUMAN

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Protein
Submitted name:

Insulin

Gene
INS
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver By similarity.SAAS annotations

GO - Biological processi

  1. glucose metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HormoneSAAS annotations

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
InsulinImported
Gene namesi
Name:INSImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Secreted By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotations

Pathology & Biotechi

Protein family/group databases

Allergomei2121. Hom s Insulin.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 8›8 PredictedImported
Chaini9 – ›94›86 PredictedImportedPRO_5000755530Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiF6MZK5.
BgeeiF6MZK5.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds By similarity.SAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.UniRule annotation

Keywords - Domaini

SignalImported

Family and domain databases

Gene3Di1.10.100.10. 2 hits.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

F6MZK5-1 [UniParc]FASTAAdd to Basket

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WGPDPAAAFV NQHLCGSHLV EALYLVCGER GFFYTPKTRR EAEDLQVGQV   50
ELGGGPGAGS LQPLALEGSL QKRGIVEQCC TSICSLYQLE NYCN 94
Length:94
Mass (Da):10,160
Last modified:July 27, 2011 - v1
Checksum:i9D57C451E8E9469E
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei94 – 941Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JF909299 mRNA. Translation: AEG19452.1.
UniGeneiHs.272259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JF909299 mRNA. Translation: AEG19452.1 .
UniGenei Hs.272259.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 2121. Hom s Insulin.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

NextBioi 35510200.

Gene expression databases

ArrayExpressi F6MZK5.
Bgeei F6MZK5.

Family and domain databases

Gene3Di 1.10.100.10. 2 hits.
InterProi IPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF00049. Insulin. 1 hit.
[Graphical view ]
PRINTSi PR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Preparation of human insulin gene construct in order to use in diabetes mellitus gene therapy."
    Piri H., Kazemi B., Bandehpour M., Rezaei M., Goodarzi M.T., Khodadadi I., Hasanzadeh T., Sirati Sabet M., Tasa D., Heidari H.R., Karimi J., Yari Khosroshahi A., Eghdami A., Tavakkoli A.H.
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PancreasImported.

Entry informationi

Entry nameiF6MZK5_HUMAN
AccessioniPrimary (citable) accession number: F6MZK5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 19, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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