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F6L6N6

- F6L6N6_HUMAN

UniProt

F6L6N6 - F6L6N6_HUMAN

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Protein
Submitted name: Synuclein alpha-140
Gene
NACP
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. arachidonic acid binding Source: Ensembl
  2. phospholipid binding Source: Ensembl

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. aging Source: Ensembl
  3. behavioral response to cocaine Source: Ensembl
  4. cellular response to fibroblast growth factor stimulus Source: Ensembl
  5. cellular response to oxidative stress Source: Ensembl
  6. dopamine biosynthetic process Source: Ensembl
  7. fatty acid metabolic process Source: Ensembl
  8. long-term synaptic potentiation Source: Ensembl
  9. microglial cell activation Source: Ensembl
  10. mitochondrial ATP synthesis coupled electron transport Source: Ensembl
  11. mitochondrial membrane organization Source: Ensembl
  12. negative regulation of dopamine metabolic process Source: Ensembl
  13. negative regulation of neuron apoptotic process Source: Ensembl
  14. negative regulation of protein phosphorylation Source: Ensembl
  15. neutral lipid metabolic process Source: Ensembl
  16. phospholipid metabolic process Source: Ensembl
  17. positive regulation of neurotransmitter secretion Source: Ensembl
  18. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  19. regulation of acyl-CoA biosynthetic process Source: Ensembl
  20. regulation of dopamine secretion Source: Ensembl
  21. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  22. regulation of glutamate secretion Source: Ensembl
  23. regulation of locomotion Source: Ensembl
  24. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  25. regulation of macrophage activation Source: Ensembl
  26. response to drug Source: Ensembl
  27. synapse organization Source: Ensembl
  28. synaptic transmission, dopaminergic Source: Ensembl
  29. synaptic vesicle endocytosis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Synuclein alpha-140Imported
Gene namesi
Name:NACPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. cytoplasmic vesicle membrane Source: Ensembl
  3. cytoskeleton Source: Ensembl
  4. cytosol Source: Ensembl
  5. growth cone Source: Ensembl
  6. mitochondrion Source: Ensembl
  7. nuclear outer membrane Source: Ensembl
  8. plasma membrane Source: Ensembl
  9. ribosome Source: Ensembl
  10. rough endoplasmic reticulum Source: Ensembl
  11. synaptic vesicle Source: Ensembl
  12. terminal bouton Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF6L6N6.

Expressioni

Gene expression databases

ArrayExpressiF6L6N6.
BgeeiF6L6N6.

Family & Domainsi

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Fragment.

F6L6N6-1 [UniParc]FASTAAdd to Basket

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MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH   50
GVATVAEKTK EQVTNVGGAV VTGVTAVAQ 79
Length:79
Mass (Da):7,931
Last modified:July 27, 2011 - v1
Checksum:i48F7584FEA865FD2
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei79 – 791Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ830267 mRNA. Translation: AEG20815.1.
HQ830268 mRNA. Translation: AEG20816.1.
HQ830269 mRNA. Translation: AEG20817.1.
UniGeneiHs.21374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HQ830267 mRNA. Translation: AEG20815.1 .
HQ830268 mRNA. Translation: AEG20816.1 .
HQ830269 mRNA. Translation: AEG20817.1 .
UniGenei Hs.21374.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F6L6N6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

ChiTaRSi SNCA. human.
NextBioi 35510173.

Gene expression databases

ArrayExpressi F6L6N6.
Bgeei F6L6N6.

Family and domain databases

Gene3Di 1.10.287.700. 1 hit.
InterProi IPR001058. Synuclein.
[Graphical view ]
PANTHERi PTHR13820. PTHR13820. 1 hit.
Pfami PF01387. Synuclein. 1 hit.
[Graphical view ]
PRINTSi PR01211. SYNUCLEIN.
ProtoNeti Search...

Publicationsi

  1. "Pro-inflammatory stimuli modulate alpha-synuclein expression in human monocyte-derived dendritic cells: role of a novel exon 1 splice variant."
    Baltic S., Thompson P.J., Misso N.L., Fogel-Petrovic M.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiF6L6N6_HUMAN
AccessioniPrimary (citable) accession number: F6L6N6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 19, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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