F6L6N6 (F6L6N6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Synuclein alpha-140 EMBL AEG20817.1

Gene names

Name:

NACP EMBL AEG20817.1

Organism

Homo sapiens (Human) EMBL AEG20817.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	79 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	adult locomotory behavior Inferred from electronic annotation. Source: Compara aging Inferred from electronic annotation. Source: Compara behavioral response to cocaine Inferred from electronic annotation. Source: Compara cellular response to fibroblast growth factor stimulus Inferred from electronic annotation. Source: Compara cellular response to oxidative stress Inferred from electronic annotation. Source: Compara dopamine biosynthetic process Inferred from electronic annotation. Source: Compara fatty acid metabolic process Inferred from electronic annotation. Source: Compara long-term synaptic potentiation Inferred from electronic annotation. Source: Compara microglial cell activation Inferred from electronic annotation. Source: Compara mitochondrial ATP synthesis coupled electron transport Inferred from electronic annotation. Source: Compara mitochondrial membrane organization Inferred from electronic annotation. Source: Compara negative regulation of dopamine metabolic process Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara neutral lipid metabolic process Inferred from electronic annotation. Source: Compara phospholipid metabolic process Inferred from electronic annotation. Source: Compara positive regulation of neurotransmitter secretion Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara regulation of acyl-CoA biosynthetic process Inferred from electronic annotation. Source: Compara regulation of dopamine secretion Inferred from electronic annotation. Source: Compara regulation of excitatory postsynaptic membrane potential Inferred from electronic annotation. Source: Compara regulation of glutamate secretion Inferred from electronic annotation. Source: Compara regulation of locomotion Inferred from electronic annotation. Source: Compara regulation of long-term neuronal synaptic plasticity Inferred from electronic annotation. Source: Compara regulation of macrophage activation Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara synapse organization Inferred from electronic annotation. Source: Compara synaptic transmission, dopaminergic Inferred from electronic annotation. Source: Compara synaptic vesicle endocytosis Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara cytoplasmic vesicle membrane Inferred from electronic annotation. Source: Compara cytoskeleton Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara growth cone Inferred from electronic annotation. Source: Compara mitochondrion Inferred from electronic annotation. Source: Compara nuclear outer membrane Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara ribosome Inferred from electronic annotation. Source: Compara rough endoplasmic reticulum Inferred from electronic annotation. Source: Compara synaptic vesicle Inferred from electronic annotation. Source: Compara terminal bouton Inferred from electronic annotation. Source: Compara
Molecular_function	arachidonic acid binding Inferred from electronic annotation. Source: Compara phospholipid binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	79	1	EMBL AEG20817.1

Sequences

	Sequence		Length	Mass (Da)
	F6L6N6 [UniParc]. Last modified July 27, 2011. Version 1. Checksum: 48F7584FEA865FD2	FASTA	79	7,931
	10 20 30 40 50 60 MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK 70 EQVTNVGGAV VTGVTAVAQ

References

[1]	"Pro-inflammatory stimuli modulate alpha-synuclein expression in human monocyte-derived dendritic cells: role of a novel exon 1 splice variant." Baltic S., Thompson P.J., Misso N.L., Fogel-Petrovic M. Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	HQ830267 mRNA. Translation: AEG20815.1. HQ830268 mRNA. Translation: AEG20816.1. HQ830269 mRNA. Translation: AEG20817.1.
IPI	IPI00218467.
UniGene	Hs.21374.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	F6L6N6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Gene expression databases
ArrayExpress	F6L6N6.
Bgee	F6L6N6.
Family and domain databases
Gene3D	1.10.287.700. 1 hit.
InterPro	IPR001058. Synuclein. [Graphical view]
PANTHER	PTHR13820. PTHR13820. 1 hit.
Pfam	PF01387. Synuclein. 1 hit. [Graphical view]
PRINTS	PR01211. SYNUCLEIN.
ProtoNet	Search...
Other
ChiTaRS	SNCA. human.
NextBio	35510173.

Entry information

Entry name

F6L6N6_HUMAN

Accession

Primary (citable) accession number: F6L6N6

Entry history

Integrated into UniProtKB/TrEMBL:	July 27, 2011
Last sequence update:	July 27, 2011
Last modified:	April 3, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.