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F6L6N6

- F6L6N6_HUMAN

UniProt

F6L6N6 - F6L6N6_HUMAN

Protein
Submitted name:

Synuclein alpha-140

Gene

NACP

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. arachidonic acid binding Source: Ensembl
    2. phospholipid binding Source: Ensembl

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. aging Source: Ensembl
    3. behavioral response to cocaine Source: Ensembl
    4. cellular response to fibroblast growth factor stimulus Source: Ensembl
    5. cellular response to oxidative stress Source: Ensembl
    6. dopamine biosynthetic process Source: Ensembl
    7. fatty acid metabolic process Source: Ensembl
    8. long-term synaptic potentiation Source: Ensembl
    9. microglial cell activation Source: Ensembl
    10. mitochondrial ATP synthesis coupled electron transport Source: Ensembl
    11. mitochondrial membrane organization Source: Ensembl
    12. negative regulation of dopamine metabolic process Source: Ensembl
    13. negative regulation of neuron apoptotic process Source: Ensembl
    14. negative regulation of protein phosphorylation Source: Ensembl
    15. neutral lipid metabolic process Source: Ensembl
    16. phospholipid metabolic process Source: Ensembl
    17. positive regulation of neurotransmitter secretion Source: Ensembl
    18. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    19. regulation of acyl-CoA biosynthetic process Source: Ensembl
    20. regulation of dopamine secretion Source: Ensembl
    21. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    22. regulation of glutamate secretion Source: Ensembl
    23. regulation of locomotion Source: Ensembl
    24. regulation of long-term neuronal synaptic plasticity Source: Ensembl
    25. regulation of macrophage activation Source: Ensembl
    26. response to drug Source: Ensembl
    27. synapse organization Source: Ensembl
    28. synaptic transmission, dopaminergic Source: Ensembl
    29. synaptic vesicle endocytosis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Synuclein alpha-140Imported
    Gene namesi
    Name:NACPImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: Ensembl
    2. cytoskeleton Source: Ensembl
    3. cytosol Source: Ensembl
    4. Golgi apparatus Source: Ensembl
    5. growth cone Source: Ensembl
    6. mitochondrion Source: Ensembl
    7. nuclear outer membrane Source: Ensembl
    8. plasma membrane Source: Ensembl
    9. ribosome Source: Ensembl
    10. rough endoplasmic reticulum Source: Ensembl
    11. synaptic vesicle Source: Ensembl
    12. terminal bouton Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiF6L6N6.

    Expressioni

    Gene expression databases

    ArrayExpressiF6L6N6.
    BgeeiF6L6N6.

    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.287.700. 1 hit.
    InterProiIPR001058. Synuclein.
    [Graphical view]
    PANTHERiPTHR13820. PTHR13820. 1 hit.
    PfamiPF01387. Synuclein. 1 hit.
    [Graphical view]
    PRINTSiPR01211. SYNUCLEIN.

    Sequencei

    Sequence statusi: Fragment.

    F6L6N6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH   50
    GVATVAEKTK EQVTNVGGAV VTGVTAVAQ 79
    Length:79
    Mass (Da):7,931
    Last modified:July 27, 2011 - v1
    Checksum:i48F7584FEA865FD2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei79 – 791Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ830267 mRNA. Translation: AEG20815.1.
    HQ830268 mRNA. Translation: AEG20816.1.
    HQ830269 mRNA. Translation: AEG20817.1.
    UniGeneiHs.21374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HQ830267 mRNA. Translation: AEG20815.1 .
    HQ830268 mRNA. Translation: AEG20816.1 .
    HQ830269 mRNA. Translation: AEG20817.1 .
    UniGenei Hs.21374.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi F6L6N6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    ChiTaRSi SNCA. human.
    NextBioi 35510173.

    Gene expression databases

    ArrayExpressi F6L6N6.
    Bgeei F6L6N6.

    Family and domain databases

    Gene3Di 1.10.287.700. 1 hit.
    InterProi IPR001058. Synuclein.
    [Graphical view ]
    PANTHERi PTHR13820. PTHR13820. 1 hit.
    Pfami PF01387. Synuclein. 1 hit.
    [Graphical view ]
    PRINTSi PR01211. SYNUCLEIN.
    ProtoNeti Search...

    Publicationsi

    1. "Pro-inflammatory stimuli modulate alpha-synuclein expression in human monocyte-derived dendritic cells: role of a novel exon 1 splice variant."
      Baltic S., Thompson P.J., Misso N.L., Fogel-Petrovic M.
      Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiF6L6N6_HUMAN
    AccessioniPrimary (citable) accession number: F6L6N6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.