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Protein

Cytochrome c oxidase subunit 2

Gene

cox2

Organism
Pipa carvalhoi (Carvalho's Surinam toad)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chainUniRule annotationSAAS annotation, Transport
LigandCopperUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotationSAAS annotation
Gene namesi
Name:cox2Imported
Encoded oniMitochondrionImported
OrganismiPipa carvalhoi (Carvalho's Surinam toad)Imported
Taxonomic identifieri191480 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaePipinaePipa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 46HelicalSequence analysisAdd BLAST20
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 91COX2_TMInterPro annotationAdd BLAST91
Domaini92 – 225COX2_CUAInterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd13912. CcO_II_C. 1 hit.
Gene3Di2.60.40.420. 1 hit.
InterProiView protein in InterPro
IPR002429. CcO_II-like_C.
IPR034210. CcO_II_C.
IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR036257. Cyt_c_oxidase_su2_TM_sf.
PfamiView protein in Pfam
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiView protein in PROSITE
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.

Sequencei

Sequence statusi: Complete.

F6KD99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHPTQLGLQ DAASPIMEEL LHFHDHTMMA AFLISTLVLY IISIMMTTKL
60 70 80 90 100
TNTNSMDAQE IEMVWTIMPA IILIVIALPS LRILYLMDEV NDPHLTVKAI
110 120 130 140 150
GHQWYWSYEY TNYEDLAFDS YMVPTNDLTP GQFRLLEVDN RMVVPMESPT
160 170 180 190 200
RMLITAEDVL HSWAMPALGI KTDAIPGRLN QTSFIITRPG VFYGQCSEIC
210 220
GANHSFMPIV VEAVPLSDFE NWSSSMLEA
Length:229
Mass (Da):25,903
Last modified:July 27, 2011 - v1
Checksum:iC06CB164AEE684A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM991332 Genomic DNA. Translation: ADM35686.1.
RefSeqiYP_004564275.1. NC_015617.1.

Genome annotation databases

GeneIDi10744089.

Similar proteinsi

Entry informationi

Entry nameiF6KD99_9PIPI
AccessioniPrimary (citable) accession number: F6KD99
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 25, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)