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Protein
Submitted name:

Phosphatase and tensin-like protein

Gene

PTEN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatase and tensin-like proteinImported
Submitted name:
Phosphatase and tensin-like protein isoform AImported
Gene namesi
Name:PTENImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSG00000171862.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361021.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 185Phosphatase tensin-typeInterPro annotationAdd BLAST172
Domaini190 – 350C2 tensin-typeInterPro annotationAdd BLAST161

Phylogenomic databases

eggNOGiKOG2283. Eukaryota.
COG2453. LUCA.
KOiK01110.
OMAiYSPCESD.
OrthoDBiEOG091G09VG.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR017361. Bifunc_PIno_P3_Pase/Pase_PTEN.
IPR000008. C2_dom.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
PF10409. PTEN_C2. 1 hit.
[Graphical view]
PIRSFiPIRSF038025. PTEN. 1 hit.
SMARTiSM01326. PTEN_C2. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F6KD01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI
60 70 80 90 100
DDVVRFLDSK HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL
110 120 130 140 150
IKPFCEDLDQ WLSEDDNHVA AIHCKAGKGR TGVMICAYLL HRGKFLKAQE
160 170 180 190 200
ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY LLKNHLDYRP VALLFHKMMF
210 220 230 240 250
ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKFMY FEFPQPLPVC
260 270 280 290 300
GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI
310 320 330 340 350
DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT
360 370 380 390 400
VEEPSNPEAS SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHTQI

TKV
Length:403
Mass (Da):47,166
Last modified:July 27, 2011 - v1
Checksum:i75F97C3DD6802BA9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei403Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM849628 Genomic DNA. Translation: ADM26753.1.
HM849629 Genomic DNA. Translation: ADM26754.1.
HM849630 Genomic DNA. Translation: ADM26755.1.
HM849631 Genomic DNA. Translation: ADM26756.1.
HM849634 Genomic DNA. Translation: ADM26759.1.
KJ534922 mRNA. Translation: AHW56562.1.
RefSeqiNP_000305.3. NM_000314.6.
UniGeneiHs.500466.
Hs.729457.

Genome annotation databases

GeneIDi5728.
KEGGihsa:5728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM849628 Genomic DNA. Translation: ADM26753.1.
HM849629 Genomic DNA. Translation: ADM26754.1.
HM849630 Genomic DNA. Translation: ADM26755.1.
HM849631 Genomic DNA. Translation: ADM26756.1.
HM849634 Genomic DNA. Translation: ADM26759.1.
KJ534922 mRNA. Translation: AHW56562.1.
RefSeqiNP_000305.3. NM_000314.6.
UniGeneiHs.500466.
Hs.729457.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361021.

Protocols and materials databases

DNASUi5728.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5728.
KEGGihsa:5728.

Organism-specific databases

CTDi5728.

Phylogenomic databases

eggNOGiKOG2283. Eukaryota.
COG2453. LUCA.
KOiK01110.
OMAiYSPCESD.
OrthoDBiEOG091G09VG.

Miscellaneous databases

ChiTaRSiPTEN. human.
GenomeRNAii5728.

Gene expression databases

BgeeiENSG00000171862.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR017361. Bifunc_PIno_P3_Pase/Pase_PTEN.
IPR000008. C2_dom.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR014020. Tensin_C2-dom.
IPR029023. Tensin_lipid_phosphatase_dom.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
PF10409. PTEN_C2. 1 hit.
[Graphical view]
PIRSFiPIRSF038025. PTEN. 1 hit.
SMARTiSM01326. PTEN_C2. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51182. C2_TENSIN. 1 hit.
PS51181. PPASE_TENSIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF6KD01_HUMAN
AccessioniPrimary (citable) accession number: F6KD01
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.